Results 151 to 160 of about 3,528,989 (183)
Some of the next articles are maybe not open access.
Targeted Radionuclide Therapy - An Overview
Current Radiopharmaceuticals, 2013Radionuclide therapy (RNT) based on the concept of delivering cytotoxic levels of radiation to disease sites is one of the rapidly growing fields of nuclear medicine. Unlike conventional external beam therapy, RNT targets diseases at the cellular level rather than on a gross anatomical level.
Ashutosh, Dash +2 more
openaire +2 more sources
Principles of Molecular Targeting for Radionuclide Therapy
2022Molecular targeting requires assessing several factors that come into play such as the location of the target, the choice of radionuclide, the inertness of the bifunctional chelate and stability of the covalently bound halogens, matching the residence time in the tumor with the physical half-life of the radionuclide, the scale and scope of the disease,
Francesco Bartoli +4 more
openaire +3 more sources
Targeted Radionuclide Therapy in Glioblastoma
ACS Applied Materials & InterfacesDespite the development of various novel therapies, glioblastoma (GBM) remains a devastating disease, with a median survival of less than 15 months. Recently, targeted radionuclide therapy has shown significant progress in treating solid tumors, with the approval of Lutathera for neuroendocrine tumors and Pluvicto for prostate cancer by the US Food and
Xiaoyuan Chen +2 more
exaly +3 more sources
The Molecular Blueprint of Targeted Radionuclide Therapy
Nature Reviews Clinical OncologyTargeted radionuclide therapy (TRT) is a cutting-edge treatment approach in oncology that combines the molecular precision of targeted agents with the effect of radiotherapy to selectively deliver cytotoxic radiation to cancer cells. Research efforts from the past few decades have led to a diverse molecular landscape of TRT and have provided lessons ...
Irina Primac +2 more
exaly +3 more sources
The Necessity of Nuclear Reactors for Targeted Radionuclide Therapies
Trends in Biotechnology, 2013Nuclear medicine has been contributing towards personalized therapies. Nuclear reactors are required for the working horses of both diagnosis and treatment, i.e., Tc-99m and I-131. In fact, reactors will remain necessary to fulfill the demand for a variety of radionuclides and are essential in the expanding field of targeted radionuclide therapies for ...
Gérard C Krijger
exaly +3 more sources
Targeted radionuclide therapy for bone metastases
European Journal of Nuclear Medicine, 1993Recent advances in targeted radiotherapy offer a new approach for the management of metastatic bone pain. This paper will review the scientific basis for radionuclide therapy and will examine the evidence for clinical efficacy. The therapeutic potential of targeted radiotherapy can only be appreciated by comparison with established treatments ...
openaire +2 more sources
Adverse Events in Targeted Radionuclide Therapy
RadioGraphicsTargeted radionuclide therapy is a rapidly growing field in the era of personalized medicine, and it is vital for physicians to recognize and appropriately manage therapy-related adverse events to deliver safe and effective patient care.
Kip E. Guja +7 more
openaire +2 more sources
Treatment Planning for Molecular Targeted Radionuclide Therapy
Cancer Biotherapy and Radiopharmaceuticals, 2002Molecular targeted radionuclide therapy promises to expand the usefulness of radiation to successfully treat widespread cancer. The unique properties of radioactive tags make it possible to plan treatments by predicting the radiation absorbed dose to both tumors and normal organs, using a pre-treatment test dose of radiopharmaceutical.
Christine Hartmann, Siantar +3 more
openaire +2 more sources
Targeted Radionuclide Therapy: A Historical and Personal Review
Seminars in Nuclear Medicine, 2020This review traces the development of targeted radionuclide therapy (TRT) (the Magic Bullet) from the discovery of radioactivity in nature and the subsequent discovery of artificial radioactivity (the production of radioactive isotopes of stable elements) to the current status of TRT in the medical literature and clinical practice.
openaire +2 more sources
Targeted radionuclide therapy for solid tumors: An overview
International Journal of Radiation Oncology*Biology*Physics, 2006Although radioimmunotherapy (RIT) has been effective in non-Hodgkin's lymphoma (NHL) as a single agent, solid tumors have shown less clinically significant therapeutic response to RIT alone. The clinical impact of RIT or other forms of targeted radionuclide therapy for solid tumors depends on the development of a high therapeutic index (TI) for the ...
Sally J, DeNardo, Gerald L, Denardo
openaire +2 more sources