Results 201 to 210 of about 26,593 (244)

Targeted Radionuclide Therapy - An Overview

Current Radiopharmaceuticals, 2013
Radionuclide therapy (RNT) based on the concept of delivering cytotoxic levels of radiation to disease sites is one of the rapidly growing fields of nuclear medicine. Unlike conventional external beam therapy, RNT targets diseases at the cellular level rather than on a gross anatomical level.
Ashutosh, Dash, F F Russ, Knapp, M R A, Pillai   +2 more
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Targeted Radionuclide Therapy in Glioblastoma

ACS Applied Materials & Interfaces
Despite the development of various novel therapies, glioblastoma (GBM) remains a devastating disease, with a median survival of less than 15 months. Recently, targeted radionuclide therapy has shown significant progress in treating solid tumors, with the approval of Lutathera for neuroendocrine tumors and Pluvicto for prostate cancer by the US Food and
Xiaobin Zhao, Vivianne Jakobsson, Yucen Tao, Tianzhi Zhao, Jingyan Wang, Pek-Lan Khong, Xiaoyuan Chen, Jingjing Zhang   +7 more
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Organs dosimetry in targeted radionuclide therapy

Radiation Physics and Chemistry, 2021
Abstract The objective of this study is to assess the patients' effective and organ dose during theranostic applications in Kuwait. In total, eighteen adults' patients were conducted nuclear medicine procedures with 177Lu Dotatate for theranostic purpose in Kuwait Cancer control center (KCCC), Kuwait.
Meshari Alnaaimi, Abdelmoneim Sulieman, Mohammed Alkhorayef, Hasan Salah, Musa Alduaij, Mosab Algaily, O. Alomair, Y. Alashban, H.I. Almohammad, David Bradley, C. Kappas   +10 more
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Principles of Molecular Targeting for Radionuclide Therapy

2022
Molecular targeting requires assessing several factors that come into play such as the location of the target, the choice of radionuclide, the inertness of the bifunctional chelate and stability of the covalently bound halogens, matching the residence time in the tumor with the physical half-life of the radionuclide, the scale and scope of the disease,
Francesco Bartoli, William C. Eckelman, Marie Boyd, Robert J. Mairs, Paola A. Erba   +4 more
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Covalent targeted radioligands potentiate radionuclide therapy

Nature
Targeted radionuclide therapy, in which radiopharmaceuticals deliver potent radionuclides to tumours for localized irradiation, has addressed unmet clinical needs and improved outcomes for patients with cancer1-4. A therapeutic radiopharmaceutical must achieve both sustainable tumour targeting and fast clearance from healthy tissue, which remains a ...
Xi-Yang Cui, Zhu Li, Ziren Kong, Yu Liu, Hao Meng, Zihao Wen, Changlun Wang, Junyi Chen, Mengxin Xu, Yiyan Li, Jingyue Gao, Wenjia Zhu, Zhixin Hao, Li Huo, Shaoyan Liu, Zhi Yang, Zhibo Liu   +16 more
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Targeted radionuclide therapy for bone metastases

European Journal of Nuclear Medicine, 1993
Recent advances in targeted radiotherapy offer a new approach for the management of metastatic bone pain. This paper will review the scientific basis for radionuclide therapy and will examine the evidence for clinical efficacy. The therapeutic potential of targeted radiotherapy can only be appreciated by comparison with established treatments ...
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Treatment Planning for Molecular Targeted Radionuclide Therapy

Cancer Biotherapy and Radiopharmaceuticals, 2002
Molecular targeted radionuclide therapy promises to expand the usefulness of radiation to successfully treat widespread cancer. The unique properties of radioactive tags make it possible to plan treatments by predicting the radiation absorbed dose to both tumors and normal organs, using a pre-treatment test dose of radiopharmaceutical.
Christine Hartmann, Siantar, Kai, Vetter, Gerald L, DeNardo, Sally J, DeNardo   +3 more
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Systemic targeted radionuclide therapy: Potential new areas

International Journal of Radiation Oncology*Biology*Physics, 2006
Radiation oncology is entering an exciting new era with therapies being delivered in a targeted fashion through an increasing number of novel approaches. External beam radiotherapy now integrates functional and anatomic tumor imaging to guide delivery of conformal radiation to the tumor target.
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Targeted Radionuclide Therapy of Prostate Cancer

2013
Prostate cancer is an ideal target for the development of targeted radionuclide therapy because of the frequent occurrence of multi-focal disseminated disease when it recurs after treatment of disease initially thought to have been confined to the prostate gland or even at presentation in patients with advanced disease.
Stanley J. Goldsmith, Scott T. Tagawa, Shankar Vallabhajosula, Anastasia Nikolopoulou, Irina Lipai, Neil H. Bander   +5 more
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Monoclonal antibody targeted radionuclide therapy

2003
Abstract The pivotal work by Kohler and Milstein (1) on the development of hybridoma technology has made the production of an unlimited supply of monoclonial antibody (mAb) molecules possible. A wide range of mAbs has been generated for applications in research and health care.
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