Results 131 to 140 of about 159,655 (310)

Some are more equal than others: responses to political violence [PDF]

, 2014
While it is true that the US has, for once, signed up to a UN Security Council statement which calls for an "immediate and unconditional humanitarian cease-fire”, this might still be considered a tactical step to prevent more strongly worded resolutions ...
Head, Naomi
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effectiveness of Trade Sanctions as an Enforcement Mechanism in Greenhouse Gas Mitigation Agreements in Agriculture and Forestry [PDF]

This study explores the conditions under which a trade sanction can be an effective enforcement mechanism used by the US against China in global greenhouse (GHG) mitigation in agriculture and forestry.
Irfanoglu, Zeynep Burcu, Sesmero, Juan P.   +1 more
core   +1 more source

Contextualizing the Plight of Iraqi Women [PDF]

, 2007
The fact that Iraqi women are living under abhorrent conditions often leads to generalized depictions of these women as faceless victims. The author draws attention to the stories and life-courses of individual Iraqi women, as these do not only give a ...
Al-Ali, Nadje
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The targeting of economic sanctions

Economics Letters
Simeon Djankov, Meng Su
openaire   +3 more sources

Self-Organization for Collective Action: An Experimental Study of Voting on Formal, Informal, and No Sanction Regimes [PDF]

Entrusting the power to punish to a central authority is a hallmark of civilization. We study a collective action dilemma in which self-interest should produce a sub-optimal outcome absent sanctions for non-cooperation.
Jean-Robert Tyran, Louis Putterman, Thomas Markussen   +2 more
core  

TANF Policies for the Hard to Employ: Understanding State Approaches and Future Directions [PDF]

, 2007
This study examines states' approaches to serving TANF recipients facing multiple barriers to work in fall 2006. It also describes changes states anticipate (partly in response to TANF reauthorization) in the near future to help these recipients move ...
Karin Martinson, Pamela A. Holcomb, Pamela Loprest, Sheila R. Zedlewski   +3 more
core