Results 81 to 90 of about 8,056 (296)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Sanctions and Economic Security: The Third-Country Dilemma

Eastern European Journal of Transnational Relations
G7 states are increasingly using economic sanctions in the conduct of their foreign policies. Such sanctions have serious impacts on third countries, even though they are not directly targeted.
Kinga Redlowska
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Targeting the Leadership of Zimbabwe [Elektronisk resurs] : A Path to Democracy and Normalization?

, 2007
This report is based on a set of interviews and observations from a research mission undertaken in Harare, Zimbabwe in September 2006. As part of a broader dissertation project conducted at the European University Institute in Florence, Italy, this field
Eriksson, Mikael,
core  

Imposition of Individually Targeted Sanctions on State Officials

, 2022
The diploma thesis examines the position of state officials in relation to individually targeted travel and financial sanctions. International individually targeted sanctions are currently one of the most widely used means of coercion international law ...
Krauz, Jakub
core   +1 more source

International Legal Responses To Iran’s Nuclear Ambitions and Human Rights Violations: A Study Of Economic Sanctions

Al-Adalah
This study analyzes the international legal response to Iran's nuclear ambitions and human rights violations, focusing on the economic sanctions imposed by the United Nations, the United States, and the European Union.
Rizky Nur Fajar, Andri Sutrisno
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Die Wirtschaftssanktionen als die Mittel der internationalen Druck während der russisch-ukrainischen Krise. Majandussanktsioonid kui rahvusvaheline survemeede: kui suured on eduvõimalused Venemaa-Ukraina kriisi puhul

Eesti Majanduspoliitilised Väitlused, 2015
To stop the conflict in Ukraine, in 2014 the European Union (EU), the United States and others western countries have introduced targeted sanctions against Russia, which where followed by countermeasures imposed by Russia.
Viljar Veebel, Raul Markus
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Economic Sanctions and International Law: An Introduction

, 2016
peer reviewedIn recent years sanctions have become an increasingly popular tool of foreign policy, not only at the multilateral level (at the UN), but also regionally (the EU in particular) and unilaterally.
HAPPOLD, Matthew
core