Results 91 to 100 of about 1,011,686 (269)

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies [PDF]

, 2023
Zhenduo Shi, Kun Pang, Zhuo‐Xun Wu, Dong Yang, Hao Lin, Jiaxin Qin, Wei Wang, Zhe‐Sheng Chen, Conghui Han   +8 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Identification and validation of three tumor suppressors associated with the immune response of acute myeloid leukemia

Frontiers in Genetics
BackgroundAcute myeloid leukemia (AML) is a heterogeneous disorder marked by irregular expansion and maturation, giving rise to the aggregation of immature myeloid precursor cells.
Yueyuan Pan, Yueyuan Pan, Yueyuan Pan, Guocai Wu, Guocai Wu, Chenchen Liu, Chenchen Liu, Chenchen Liu, Minggui Chen, Tian Xia, Tian Xia, Yonghua Ma, Yonghua Ma, Zhigang Yang, Zhigang Yang, Zhigang Yang, Ruiting Wen, Ruiting Wen   +17 more
doaj   +1 more source

A dual-targeted multifunctional nanoformulation for potential prevention and therapy of Alzheimer's disease

, 2021
Dongju Zhao, Yuqing Tang, Xinjun Suo, Chaonan Zhang, Yan Dou, Jin Chang   +5 more
openalex   +1 more source

A90 A UTILITY-BASED BAYESIAN OPTIMAL INTERVAL (U-BOIN) PHASE I/II DESIGN TO IDENTIFY THE OPTIMAL BIOLOGICAL DOSE FOR TARGETED AND IMMUNE THERAPIES [PDF]

, 2020
Yanhong Zhou, Juhun Lee, Ying Yuan
openalex   +1 more source

Mining whole-lung information by artificial intelligence for predicting EGFR genotype and targeted therapy response in lung cancer: a multicohort study [PDF]

, 2022
Shuo Wang, He Yu, Yuncui Gan, Zhangjie Wu, Encheng Li, Xiaohu Li, Jingxue Cao, Yongbei Zhu, Liusu Wang, Hui Deng, Mei Xie, Yuanyong Wang, Xidong Ma, Dan Liu, Bojiang Chen, Panwen Tian, Zhixin Qiu, Jinghong Xian, Jing Ren, Kun Wang, WEI WEI, Fei Xie, Zhenhui Li, Qi Wang, Xinying Xue, Zai-yi Liu, Jingyun Shi, Weimin Li, Jie Tian, Shuo Wang, He Yu, Yuncui Gan, Encheng Li, Xiaohu Li, Jingxue Cao, Yongbei Zhu, Hui Deng, Mei Xie, Yuanyong Wang, Xidong Ma, Dan Liu, Bojiang Chen, Panwen Tian, Zhixin Qiu, Kun Wang, WEI WEI, Fei Xie, Zhenhui Li, Qi Wang, Xinying Xue, Zai-yi Liu, Jingyun Shi, Weimin Li, Jie Tian   +53 more
openalex   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source