Results 151 to 160 of about 927,175 (307)
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Instructional Theory and Technology for the New Paradigm of Education
RED. Revista de Educación a Distancia, 2012 This article describes instructional theory that supports post-industrial education and training systems - ones that are customized and learner-centered, in which student progress is based on learning rather than time.
Charles M. Reigeluth
doaj
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Focus On Form Instruction In Task-Based Language Classroom
İlköğretim Online, 2019 From the perspective of Second Language Acquisition (SLA), TBLT is intriguing because it tries to solve the dilemma of keeping learners' attention on the meaning and doing things with language while simultaneously including the construction of their languageresources into the teaching cycle.
D.Shaby, John Love Joy
openaire +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
A study of large language models for patient information extraction: Model architecture, fine-tuning strategy, and multi-task instruction tuning. [PDF]
J Biomed InformPeng C +5 more
europepmc +1 more source
Evaluating the effectiveness of task-based instruction on students' output
, 2015 The communicative approach is rapidly gaining ground in second language teaching as the need to communicate in the target language becomes greater. However it is still unclear which tasks and types of pairing are more effective. This study was undertaken in an attempt to clarify which types of communicative task (open or closed) better promoted ...
Amezcua Chopard, Jessica +1 more
openaire +1 more source