Results 71 to 80 of about 1,766,433 (345)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Classes of decision analysis [PDF]

, 2016
The ultimate task of an engineer consists of developing a consistent decision procedure for the planning, design, construction and use and management of a project.
Caspeele, Robby, Val, Dimitri, Xing, Cheng   +2 more
core   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Factors influencing the project success in manufacturing organizations

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kinh tế và Quản trị kinh doanh, 2020
The paper aims to identify and measure factors affecting project success in manufacturing organizations. The influential factors are adapted from the PIP model of Slevin and Pinto (1986). From the 203 collected samples, the research model is verified and
Nguyễn Thúy Quỳnh Loan, Nguyễn Vương Chi, Nguyễn Trần Quốc Khanh   +2 more
doaj   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Estimation of the resource buffers in the assembly process of a shearer machine in the CPPM method

MATEC Web of Conferences, 2017
Dynamic development of scheduling systems allows significantly improving currently realized tasks. Critical Chain Project Management (CCPM) is one of the methods of project management basing on network planning.
Gwiazda Aleksander, Paprocka Iwona, Bączkowicz Magdalena   +2 more
doaj   +1 more source

A Principal Component Analysis of Project Management Construction Industry Competencies for the Ghanaian

Construction Economics and Building, 2011
The study adopts a data reduction technique to examine the presence of any complex structure among a set of project management competency variables. A structured survey questionnaire was administered to 100 project managers to elicit relevant data, and ...
Rockson Dobgegah, De-Graft Owusu-Manu, Kamil Omoteso   +2 more
doaj   +1 more source

Liquid Rocket Booster (LRB) for the Space Transportation System (STS) systems study. Study plan [PDF]

The two major objectives are: to present the study approach, and to provide the standard for guiding the Liquid Rocket Booster (LRB) project. The task plans provide a comprehensive description of the work to be performed.

core   +1 more source

Selecting projects in a portfolio using risk and ranking

, 2011
There are three dimensions in project management: time, cost and performance. Risk is a characteristic related to the previous dimensions and their relationships.
Copertari, Luis
core   +1 more source