Results 81 to 90 of about 1,766,433 (345)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Project Management Organisation in Public Authorities

Управленческие науки, 2016
The aspects of implementing the system of project management into public authorities are considered in the article. The project management topicality is stipulated by new challenges in the system of Russia public administration. Executive bodies’ ability
A. I. Vasilyev, S. Ye. Prokofyev
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Generalization of the critical chain method supporting the management of projects with a high degree of uncertainty and imperfect information [PDF]

In the critical chain method the fundamental notion is the project buffer, and its length is based on task estimation risk. This estimation is almost never unequivocal. If it is not correct, the whole method may turn out to be ineffective.
Dorota Kuchta
core  

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Evaluation of team dynamic in Norwegian projects for IT students [PDF]

, 2018
The need for teaching realistic software development in project courses has increased in a global scale. It has always been challenges in cooperating fast-changing software technologies, development methodologies and teamwork.
Ahmed, Salah Uddin, Gulla, Jon Atle, Jaccheri, Letizia, Kvisli, Jon, Nguyen-Duc, Anh, Sundbø, Ingrid   +5 more
core   +2 more sources

Large scale railway renewal planning with a multiobjective modeling approach [PDF]

, 2018
Conferência realizada na Filândia, Helsinquia, de 20-24 de agosto de 2018A multiobjective modeling approach for managing large scale railway infrastructure asset renewal is presented.
Almeida, Luís Alçada, Rodrigues, João Coutinho, Sousa, Nuno   +2 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Metaverse adoption for the teaching and learning of project management: an exploratory study of student use

International Journal of Information Systems and Project Management
The rapid adoption of collaboration technologies over the course of the COVID-19 pandemic, combined with the advancement, growth, and proliferation of metaverse technology capabilities, has created a heightened awareness and comfort with the use of ...
Alanah Mitchell
doaj   +1 more source