Results 71 to 80 of about 3,354,478 (288)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Perceived feasibility of peer-delivered mental health and psychosocial support interventions for people living with HIV/AIDS at Ryan White-funded clinics in the southeastern United States: a Consolidated Framework for Implementation Research study of health care worker perspectives

Frontiers in Health Services
BackgroundPeople living with HIV/AIDS and violence-related trauma histories (PLWH/T) may have unmet mental health needs due to high rates of mental disorders coupled with mental health provider shortages, as well as other barriers to care. Our prior work
Caroline W. Kokubun, Sophia C. Garbarino, Celeste K. Ellison, Benjamin G. Druss, Briana A. Woods-Jaeger, Ameeta S. Kalokhe, Ameeta S. Kalokhe, Jessica M. Sales   +7 more
doaj   +1 more source

A new health care profession in rural district hospitals: a case study of the introduction of Clinical Associates in Shongwe hospital

South African Family Practice, 2017
Background: One of the reasons to develop training courses for medical mid-level workers in South Africa is a shortage of doctors. The introduction of this new profession has led to task sharing and redefining of professional boundaries.
M Bac, J M A Hamm, P C van Bodegraven, B Pater, J M Louw   +4 more
doaj   +1 more source

The Effect of Mutual Task Sharing on the Number of Needed Health Workers at the Iranian Health Posts; Does Task Sharing Increase Efficiency? [PDF]

International Journal of Health Policy and Management, 2015
Background Nowadays task sharing is a way to optimize utilization of human resources for health. This study was designed to assess the effect of task sharing, mutually between midwives and Family Health Workforces (FHWs), on the number of needed staff ...
Ali Fakhri, Aidin Aryankhesal
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Port of Honolulu Industry and Public Sector Cooperation for Information Sharing / Spring 2010 [PDF]

, 2010
(MIST Honolulu)MIST held its third event in Honolulu on November 22-23, 2009. Using a participatory design approach, NPS researchers partnered with federal and commercial stakeholders to hold a workshop to assess the information sharing needs of security
Englehorn, Lyla|Hocevar, Susan, Walsh, Wendy, Salem, Anita   +2 more
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Optimizing the roles of health workers to improve access to health services in Africa: an implementation framework for task shifting and sharing for policy and practice

BMC Health Services Research, 2023
Background Globally, countries are taking actions to ensure that their population have improved access to people-centred and integrated health services.
Sunny C Okoroafor, Christmal Dela Christmals   +1 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source