Results 71 to 80 of about 200,479 (292)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Task Switching and Distractibility [PDF]

open access: yes, 2007
In this thesis I examined the effects of task switching on people’s ability to ignore irrelevant distractors. Load theory proposes that distractor interference critically depends on the availability of executive control to minimise the effects of ...
Brand, Sarah Louise
core  

Sharing Different Reference Frames: How Stimulus Setup and Task Setup Shape Egocentric and Allocentric Simon Effects

open access: yesFrontiers in Psychology, 2018
Different reference frames are used in daily life in order to structure the environment. The two-choice Simon task setting has been used to investigate how task-irrelevant spatial information influences human cognitive control.
Pamela Baess   +2 more
doaj   +1 more source

Multi-Task Learning Based on Stochastic Configuration Networks

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
When the human brain learns multiple related or continuous tasks, it will produce knowledge sharing and transfer. Thus, fast and effective task learning can be realized. This idea leads to multi-task learning.
Xue-Mei Dong   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Towards sharing task environments to support reproducible evaluations of interactive recommender systems

open access: yes, 2019
Beyond sharing datasets or simulations, we believe the Recommender Systems (RS) community should share Task Environments. In this work, we propose a high-level logical architecture that will help to reason about the core components of a RS Task ...
d\u27Aquin, Mathieu   +2 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Merit overrules theory of mind when young children share resources with others.

open access: yesPLoS ONE, 2020
Non-windfall approaches to sharing demonstrate pre-schoolers' sensitivity to merit-based distributions of resources. However, such studies have not considered (1) whether epistemic aspects of task performance, such as the relative accuracy of a co-worker,
James Stack, Carlos Romero-Rivas
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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