Results 81 to 90 of about 200,479 (292)

South Carolina Human Trafficking Task Force newsletter

, 2021
This quarterly newsletter is released by the South Carolina Human Trafficking Task Force. As South Carolina's anti-human trafficking movement continues to grow, the State Task Force designed this newsletter to promote information sharing and ...
South Carolina Human Trafficking Task Force
core  

Task sharing: Development of evidence‐based co‐management strategy model for screening, detection, and management of diabetic retinopathy [PDF]

, 2018
Background: The number of adults with diabetes is increasing worldwide and also the number of people with diabetic retinopathy (DR), a major complication of diabetes.
Ayesha Noor, Keeffe, JE, Keeffe, Jill Elizabeth, Colin Alex Harper, Jill Elizabeth Keeffe, Ormsby, Gail M., Harper, Colin Alex, Mufarriq Shah, Noor, A, Shah, Mufarriq, Noor, Ayesha, Fakir Amirul Islam, Keeffe, Jill E, Ormsby, GM, Islam, Fakir Amirul, Gail M. Ormsby, Shah, M, Islam, FA, Harper, CA   +18 more
core   +1 more source

Comparing implementation strategies for training and supervising nonspecialists in Group Problem Management Plus: A hybrid effectiveness-implementation trial in Colombia

Cambridge Prisms: Global Mental Health
Migrants and refugees face elevated risks for mental health problems but have limited access to services. This study compared two strategies for training and supervising nonspecialists to deliver a scalable psychological intervention, Group Problem ...
M. Claire Greene, Diany Castellar, Manaswi Sangraula, Natalia Camargo, Jennifer Diaz, Valeria Meriño, Lucy Miller-Suchet, Ana Maria Chamorro Coneo, Marcela Venegas, Maria Cristobal, David Chávez, Brandon Kohrt, Peter Ventevogel, Miguel Uribe, Marilyn DeLuca, James Shultz, Zelde Espinel, Leslie Snider, Lisa Marsch, Sara Romero, Monica Ferrer, Abel Guerrero Gonzalez, Camilo Ramirez, Ana Maria Trejos Herrera, Matthew Schojan, Annie G. Bonz, Adam Brown   +26 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The effectiveness of Problem Management Plus at 1-year follow-up for Syrian refugees in a high-income setting

Epidemiology and Psychiatric Sciences
Aims Problem Management Plus (PM+) has been effective in reducing mental health problems among refugees at three-month follow-up, but there is a lack of research on its long-term effectiveness.
Anne M. de Graaff, Pim Cuijpers, Mariam Elsawy, Sam Hunaidy, Barbara Kieft, Noer Gorgis, Jos W. R. Twisk, Yenovk Zakarian, Theo K. Bouman, Miriam J. J. Lommen, Ceren Acarturk, Richard Bryant, David McDaid, Naser Morina, A-La Park, Peter Ventevogel, Marit Sijbrandij   +16 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Bridging the human resource gap in surgical and anesthesia care in low-resource countries: a review of the task sharing literature

Human Resources for Health, 2017
Task sharing, the involvement of non-specialists (non-physician clinicians or non-specialist physicians) in performing tasks originally reserved for surgeons and anesthesiologists, can be a potent strategy in bridging the vast human resource gap in ...
Tigistu Ashengo, Alena Skeels, Elizabeth J. H. Hurwitz, Eric Thuo, Harshad Sanghvi   +4 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source