Results 61 to 70 of about 1,510,912 (287)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Association between Taste Disorder and Dietary Quality and Macronutrient Intake in US Adults: A National Health and Nutrition Examination Survey (2011–2014)

International Journal for Vitamin and Nutrition Research
Background: Taste disorders are associated with various health conditions, including COVID-19. However, the prevalence and correlation of taste disorders are not comprehensively described at the population level. This study aimed to (i)
Zhihong Zhang, Jinxin Lin, Nan Wang, Ruixuan Wang, Lin Yang, Chao Cao, Xiaobin Zheng   +6 more
doaj   +1 more source

Gustatory dysfunction

Journal of Pharmacy and Bioallied Sciences, 2014
Tastes in humans provide a vital tool for screening soluble chemicals for food evaluation, selection, and avoidance of potentially toxic substances. Taste or gustatory dysfunctions are implicated in loss of appetite, unintended weight loss, malnutrition,
T Maheswaran, P Abikshyeet, G Sitra, S Gokulanathan, V Vaithiyanadane, S Jeelani   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Tobacco Influence on Taste and Smell: Systematic Review of the Literature

International Archives of Otorhinolaryngology, 2018
Introduction In Brazil, estimates show that 14.7% of the adult population smokes, and changes in smell and taste arising from tobacco consumption are largely present in this population, which is an aggravating factor to these dysfunctions ...
Allessandra Fraga Da Ré, Léia Gonçalves Gurgel, Gabriela Buffon, Weluma Evelyn Rodrigues Moura, Deisi Cristina Gollo Marques Vidor, Márcia Angelica Peter Maahs   +5 more
doaj   +1 more source

Ethyl loflazepate as a treatment for patients with idiopathic and psychogenic taste disorder

BioPsychoSocial Medicine, 2022
Background Ethyl loflazepate (EL) is a benzodiazepine derivative that has been reported to activate the gustatory cortex. Our department routinely uses EL as a first-line treatment for idiopathic and psychogenic taste disorders, although little has been ...
Ken-ichiro Sakata, Hiroyuki Hato, Jun Sato, Takashi Iori, Noritaka Ohga, Haruhisa Watanabe, Yutaka Yamazaki, Yoshimasa Kitagawa   +7 more
doaj   +1 more source

Factors that Influence Taste Disorders Affect Salt Intake in Chronic Kidney Disease

High sodium intake infuences the development of chronic kidney disease (CKD). Various factors can infuence sodium consumption, one of which is impaired taste perception.
Shiela Stefani, Laella Kinghua Liana, Janice Natalia, Ardo Sanjaya, Teresa Liliana Wargasetia, Meilinah Hidayat, Ronny Lesmana, Johan Lucianus   +7 more
core   +1 more source

Taste This Biography and CV [PDF]

, 1999
Short biography and chronology of works for Taste This.

core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source