Results 211 to 220 of about 5,125 (296)

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Single-molecule methods for characterizing receptor dimers reveal metastable opioid receptor homodimers that induce functional modulation. [PDF]

Nat Commun
Zhou P, Tsunoyama TA, Kasai RS, Hirosawa KM, Kalay Z, Aladag A, Fujiwara TK, Yokoyama T, Sakamoto M, Kise R, Yanagawa M, Inoue A, Pigolotti S, Kusumi A.   +13 more
europepmc   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

Excitation and mechanical contraction of a 3D cardiomyocyte model. [PDF]

Biophys J
Hatano A, Mochizuki Y, Sakakima H, Izumi S, Hoshijima M, Ellisman M, McCulloch AD.   +6 more
europepmc   +1 more source

Multi‐Dimensional Physical‐Layer Security via Digitally Mediated Space–Time Modulation

Advanced Science, EarlyView.
Digitally mediated space–time modulation moves radiation control beyond hardware‐bound switching. Multiple information‐bearing and masking waveforms are jointly synthesized at baseband and coherently coupled to simple periodic time modulation, enabling programmable, independently directed multi‐beam radiation without increasing switching‐state ...
Kejin Chen, Heng Mao, Feng Yang, Gengbo Wu, Lei Zhang, Yikai Chen, Shi‐Wei Qu, Jun Hu, Shiwen Yang   +8 more
wiley   +1 more source

Turnaround Time and Patients' Perceptions of Clinical Laboratory Services at a Tertiary Hospital in Pakistan: A Cross-Sectional Study. [PDF]

Health Sci Rep
Basit AA, Usman M, Fakih N, Akram L, Nighat A, Rehman ZU.   +5 more
europepmc   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Factors Impeding the Timely Pathologic Diagnosis of Malignant Small Round Blue Cell Tumors in a Pediatric Tertiary Care Center in the Philippines: Identifying Opportunities to Optimize Pediatric Cancer Management. [PDF]

Asian Pac J Cancer Prev
Armada GL, Matabang CC, Sionzon M, Lo R, Ilagan C, Putra J, Carreon CK.   +6 more
europepmc   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Quality indicators and turnaround time for blood culture in pediatric patients: 1 year of monitoring in 19 Chinese hospitals. [PDF]

BMC Pediatr
Wu H, Liu W, Peng Y, Qu L, Lin L, Mo B, Cao X, Zhou H, Chen D.   +8 more
europepmc   +1 more source