Results 91 to 100 of about 1,021,795 (377)

A distinct plasmablast and naïve B-cell phenotype in primary immune thrombocytopenia

Haematologica, 2016
Primary immune thrombocytopenia is an autoimmune disorder in which platelet destruction is a consequence of both B- and T-cell dysregulation. Flow cytometry was used to further characterize the B- and T-cell compartments in a cross-sectional cohort of 26
Shaun M. Flint, Adele Gibson, Geoff Lucas, Raghava Nandigam, Louise Taylor, Drew Provan, Adrian C. Newland, Caroline O. Savage, Robert B. Henderson   +8 more
doaj   +1 more source

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

Journal of Experimental Medicine, 2020
Barthélemy et al. use mass spectrometry to characterize plasma tau isoforms and assess their diagnosis utility for Alzheimer’s disease. They demonstrate plasma tau phosphorylation measures of p-tau-217 and p-tau-181 are increased with amyloid.
Nicolas R. Barthélemy, Kanta Horie, C. Sato, R. Bateman   +3 more
semanticscholar   +1 more source

Plasma tau complements CSF tau and P‐tau in the diagnosis of Alzheimer's disease

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
AbstractIntroductionPlasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho‐tau (P‐tau) are still unclear.MethodsPlasma‐tau, CSF‐tau, and P‐tau were measured in 97 subjects, including elderly cognitively ...
Yi Li, Jaime Ramos Cejudo, Tracy Butler, Elizabeth Pirraglia, Jingyun Chen, Mony J. de Leon, Henrik Zetterberg, Kaj Blennow, Kaj Blennow, Silvia Fossati, Ludovic Debure, Je Yeong Sone   +11 more
openaire   +5 more sources

Longitudinal Study of Salivary Biomarkers in the Definition of Clinico‐Molecular Progression of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo, Daniele Belvisi, Matteo Costanzo, Claudia Caturano, Francesco Emanuele Bellomi, Carolina Cutrona, Flavia Aiello, Giorgio Leodori, Massimo Marano, Romina Mancinelli, Antonella Conte, Giovanni Fabbrini, Alfredo Berardelli, Giorgio Vivacqua   +13 more
wiley   +1 more source

Production of $(\tau^+\tau^-)_b$ in electron positron collisions

, 2008
$(\tau^+\tau^-)_b$ is an atom of simple hydrogenlike structure similar to positronium $(e^+e^-)_b$ and $(\mu^+\mu^-)_b$. In this paper energy levels and decay widths of different decay channels of $(\tau^+\tau^-)_b$ are given. Cross section of production
A. A. MALIK, Anashin V. V., Bayer V. N., I. S. SATSUNKEVICH, Malik A. A., Marciano W. J.   +5 more
core   +1 more source

Plasma p‐tau181 as a Marker of Conversion to Alzheimer's Disease Dementia and Worsening in Cognitive Functions in Subjective Cognitive Decline and Mild Cognitive Impairment: A Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Plasma p‐tau181 has proven to be a promising diagnostic and prognostic tool in the earliest phases of Alzheimer's disease (AD). We aimed to evaluate the prognostic role of p‐tau181 in predicting conversion to AD dementia and worsening in cognition in mild cognitive impairment (MCI) and subjective cognitive decline (SCD).
Giulia Giacomucci, Assunta Ingannato, Chiara Crucitti, Silvia Bagnoli, Elisa Marcantelli, Sonia Padiglioni, Valentina Moschini, Carmen Morinelli, Laura Falsini, Sandro Sorbi, Valentina Berti, Benedetta Nacmias, Valentina Bessi   +12 more
wiley   +1 more source

LPS-induced serum TNF production and lethality in mice: effect of L-carnitine and some acyl-derivatives

Mediators of Inflammation, 1993
The effect of L-carnitine and some of its acyl derivatives on serum TNF production and lethality in a murine experimental endotoxin shock model was investigated. In some instances, serum IL-6 production was also evaluated.
Vito Ruggiero, Claudio M. D'Urso, Claudio Albertoni, Silvia Campo, Piero Foresta, Edoardo Arrigoni Martelli   +5 more
doaj   +1 more source

A interação argumentativa no discurso literário: da literatura das ideias ao relato de ficção

Linha D'Água, 2016
A dimensão argumentativa do texto literário se expressa na capacidade de orientar a visão de seus leitores. A teoria de Perelman inscreve a interação argumentativa no discurso do orador e os trabalhos contemporâneos em Linguística Pragmática e em ...
Ruth Amossy
doaj   +1 more source

Constraints on the charged scalar effects using the forward-backward asymmetry on $B\to D^{(*)}\tau\bar{\nu_{\tau}}$

, 2013
The decay modes $\bar{B}\to D^{(*)}\tau\bar{\nu}_{\tau}$ are sensitive to charged scalar effects, such as the charged Higgs effects. In this paper we suggest a method to determine their effects by using the ratio of branching fractions and forward ...
Sakaki, Yasuhito, Tanaka, Hidekazu
core   +1 more source

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source