Results 211 to 220 of about 315,874 (315)

Targeted degradation of aberrant Tau for the discovery of Pulsatilla chinensis in Alzheimer's disease. [PDF]

Chin Med
Deng L, Yin C, Zhou X, Feng C, Wu J, An X, Mi J, Huang L, Qin D, Yu L, Chen T, Wu A.   +11 more
europepmc   +1 more source

Ultrasmall High‐Entropy Materials: Nanoscale Effects, Synthesis, and Mechanistic Insights

Advanced Functional Materials, EarlyView.
This review article focuses on sub‐10 nm high‐entropy materials that combine nanoscale design with complex compositions for next‐generation applications. ABSTRACT Ultrasmall high‐entropy nanomaterials (USHENMs, <10 nm) merge multicomponent chemistry with size‐dependent effects, forming a distinct class of materials with unprecedented properties.
Yueyue He, Wenbo Wang, Simon Schweidler, Yanjiao Ma, Ben Breitung, Torsten Brezesinski   +5 more
wiley   +1 more source

Five-year change in brain metabolism across the spectrum of cognitive impairment in older adults: a quantitative MRI study. [PDF]

Alzheimers Dement
Wu J, Oishi K, Soldan A, Pettigrew C, Lin Z, Zhu Y, Jiang D, Li X, Gou Y, Moghekar A, Liu P, Bakker A, Oishi K, Albert M, Lu H.   +14 more
europepmc   +1 more source

Pickering‐Engineered Microparticles for Magnetically Guided Motion and Light‐Triggered Catalysis

Advanced Functional Materials, EarlyView.
Magnetically responsive wax microparticles stabilized by hematite cubes through the Pickering emulsification strategy are developed, showing controlled size, motion, and light‐activated catalytic activity. Annealing under a magnetic field enhances their mobility and steering.
Chiara Ferlito, Ludovico Guercio, Giuseppe Cavallaro, Giuseppe Lazzara, Theodore Hueckel, Lorenzo Lisuzzo, Stefano Sacanna   +6 more
wiley   +1 more source

Beyond Inhibition: Rebalancing the Hsp90 Chaperone Network as a Therapeutic Strategy for Alzheimer's Disease. [PDF]

Drug Des Devel Ther
Tang Z, Xie H, Xu Y, Zhou Z, Lu F, Wu Q, Liang W, Zhong M, Li S.   +8 more
europepmc   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Hierarchical MXene‐Derived NTP/C Nanohybrids for Cryogenic Sodium‐Ion Batteries

Advanced Functional Materials, EarlyView.
A hierarchical MXene‐derived NaTi2(PO4)3/C nanohybrid enables efficient sodium‐ion storage down to −40°C by integrating fast ion–electron transport pathways with an ether‐based electrolyte. The system promotes dominant pseudocapacitive behavior and forms a robust inorganic‐rich SEI, collectively mitigating kinetic and interfacial limitations, thereby ...
M. Sai Bhargava Reddy, Mohammad Zaid, Sayan Das, Sooryadas Sudhakaran, Shampa Aich, Vilas G. Pol   +5 more
wiley   +1 more source

Imaging and plasma biomarkers for pathological accumulation in Down syndrome. [PDF]

Brain
Wisch JK, Jiao Z, Kennedy JT, Cohen AD, Schlachetzki Z, Petersen M, Handen BL, Christian BT, Mapstone M, Rosas HD, Lai F, Lee JH, Krinsky-McHale SJ, Schmitt FA, Harp JP, Hom C, Lott IT, Hartley S, Zaman S, Ptomey L, Burns JM, Tudorascu D, Ibanez L, Rafii MS, Head E, Ances BM.   +25 more
europepmc   +1 more source

Packed Hydrogel Microfibers as Scaffolds Supporting Dynamic Cellular Behavior and Biomaterial Inks in 3D Printing

Advanced Healthcare Materials, EarlyView.
Packed hydrogel microfiber (PHM) materials consist of flexible and high aspect ratio hydrogel components that, as a bulk material, are simultaneously mechanically robust and dynamic. Cells cultured in or on PHM scaffolds can be influenced by topographical cues or interact with a dynamic environment that permits cell spreading and multicellular ...
M. Gregory Grewal, Remington M. Martinez, Georgia T. Helein, Montserrath G. Ibarra Rivera, Rodolfo Martinez Jr., Jenna L. Sumey, Steven R. Caliari, Christopher B. Highley   +7 more
wiley   +1 more source

Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments. [PDF]

Elife
Lövestam S, Wagstaff JL, Katsinelos T, Shi J, Freund SMV, Goedert M, Scheres SHW.   +6 more
europepmc   +1 more source