Results 231 to 240 of about 212,588 (266)

Tau Oligomers

2019
The accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including Alzheimer's disease. However, it is not the filamentous aggregates themselves, but non-filamentous tau species, tau oligomer, that is thought to be the culprit in tau-mediated neurodegeneration.
Sumihiro, Maeda, Akihiko, Takashima
openaire   +2 more sources

Tau Condensates

2019
Many proteins, particularly those that are intrinsically disordered and carry charges have a tendency to undergo liquid liquid phase separation (LLPS). Phase separation is a widespread mechanism by which cells concentrate a set of proteins to perform molecular reactions, and appear to compartmentalize molecular functions.
Kenneth S, Kosik, Songi, Han
openaire   +2 more sources

Measurement of the Decays $\tau^- \to K^*$ $\nu_\tau$ and $\tau^- \to \rho^- \nu_\tau$

1988
Using the ARGUS detector at DORIS II, we have determined the branching ratios for the decays τ−→K*−vτ and τ−→ρ−vτ to be (1.23 ±0.21−0.21+0.11)% and (21.5±0.4±1.9)%, respectively. These results are in agreement with theoretical expectations based on the standard model.
Albrecht, H., Bockmann, P., Sefkow, F., Spengler, J., Wurth, R., Yagil, A., Appuhn, R. D., Drescher, A., Hast, C., Kamp, D., Kolanoski, H., Lindner, A., Glaser, R., Mankel, R., Matthiesen, U., Scheck, H., Schweda, G., Spaan, B., Walther, A., Wegener, D., Gabriel, J. C., Ruf, T., Schael, S., Harder, G., Schubert, Klaus R., Stiewe, J., Strahl, K., Waldi, R., Werner, S., Edwards, K. W., Frisken, William R., Kapitza, H., Kutschke, Robert K., MacFarlane, D. B., Kruger, A., McLean, K. W., Nilsson, A. W., Orr, R. S., Parsons, J. A., Patel, P. M., Prentice, J. D., Seidel, S. C., Swain, J. D., Tsipolitis, G., Yoon, T. S., Nippe, A., Ammar, R., Ball, S., Coppage, D., Davis, R., Kanekal, S., Kwak, N., Bostjancic, B., Kernel, G., Krizan, P., Kriznic, E., Schafer, M., Plesko, M., Cronstrom, H. I., Jonsson, L., Babaev, A., Danilov, M., Fominykh, B., Golutvin, A., Gorelov, I., Lyubimov, V., Rostovtsev, A., Schmidt-Parzefall, W., Semenov, A., Semenov, S., Shevchenko, V., Soloshenko, V., Chistilin, V., Tikhomirov, I., Zaitsev, Yu., Childers, R., Darden, C. W., Fernholz, R. C., Schroder, H., ARGUS Collaboration, Schulz, H. D.   +80 more
openaire   +1 more source

Tau Fibrillogenesis

2012
The protein tau is the most abundant microtubule associated protein in the central and peripheral nervous system. In the brain, tau plays a role in the assembly and stabilization of microtubules. The function of tau, however, appears to overlap with other microtubule binding proteins.
Nitin, Chaudhary, Ramakrishnan, Nagaraj
openaire   +2 more sources

A nose for tau

Science Translational Medicine
Nasal delivery of an oligomeric tau antibody loaded into micelles reduces pathology and ameliorates cognition in a mouse model of tauopathy.
Soraya Meftah, Claire S. Durrant, Tara L. Spires-Jones   +2 more
openaire   +2 more sources

TYK2 on tau

Science Signaling
The kinase TYK2 facilitates pathological tau assembly through protein-stabilizing modifications.
openaire   +2 more sources

Tau Secretion

2019
The pathological propagation of Tau protein is a hallmark of multiple neurodegenerative disorders, collectively referred to tauopathies with Alzheimer's disease (AD) being most prevalent, but including a range of frontotemporal dementias (FTDs). The extracellular Tau is important during the progression of tauopathies, although Tau is mainly expressed ...
Zhi, Ruan, Tsuneya, Ikezu
openaire   +2 more sources

Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons

Cell Stem Cell, 2022
Andrew Yoo, Henry Houlden, Celeste Karch   +2 more
exaly  

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Cell, 2022
Danielle L Swaney, Ruth Hüttenhain, Maria Telpoukhovskaia   +2 more
exaly  

Engineering a pathological tau-targeted nanochaperone for selective and synergetic inhibition of tau pathology in Alzheimer's Disease

Nano Today, 2022
, Fan Huang, Guidong Chen
exaly