Results 311 to 320 of about 219,363 (324)

Clinical Performance of LucentAD Complete: A Multi-Analyte Algorithmic Blood Test for Detecting Brain Amyloid with a Scalable, Multiplexed Digital Immunoassay

Wilson D, Copeland K, Vasko A, Hesterberg L, Khare M, Wolfe M, Sheehy P, Verberk IM, Miller M, Teunissen CE.   +9 more
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Tau internalization: A complex step in tau propagation

Ageing Research Reviews, 2021
Aggregation of microtubule-associated protein Tau (MAPT) may underlie abnormalities of the intracellular matrix and neuronal death in tauopathies. Tau proteins can be secreted to the extracellular space and internalized into adjacent cells. The internalization of Tau is a complex but critical step in Tau propagation.
Jianfeng Zhao, Xiao-qing Tang, Hongrong Wu   +2 more
openaire   +3 more sources

Tau protein and tau aggregation inhibitors

Neuropharmacology, 2010
Alzheimer disease is characterized by pathological aggregation of two proteins, tau and Abeta-amyloid, both of which are considered to be toxic to neurons. In this review we summarize recent advances on small molecule inhibitors of protein aggregation with emphasis on tau, with activities mediated by the direct interference of self-assembly.
Eckhard Mandelkow, Bruno Bulic, Eva-Maria Mandelkow, Marcus Pickhardt   +3 more
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Tau, tau kinases, and tauopathies: An updated overview

BioFactors, 2023
AbstractTau is a macrotubule‐associated protein primarily involved in the stabilization of the cytoskeleton. Under normal conditions, phosphorylation reduces the affinity of tau for tubulin, allowing the protein to detach from microtubules and ensuring the system dynamics in neuronal cells.
Giulia Montalto, Roberta Ricciarelli
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Tau and Tauopathies

Neurology India, 2007
Tau protein is a neuronal microtubule-associated protein (MAP), which localizes primarily in the axon. It is one of the major and most widely distributed MAPs in the central nervous system. Its biochemistry and molecular pathology is being increasingly studied. Tau is a key component of neurofbrillary tangles in Alzheimer's disease (AD). Disorders with
Mathuranath, PS, Robert, M
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Granular Tau Oligomers as Intermediates of Tau Filaments

Biochemistry, 2007
Neurofibrillary tangles (NFTs) are pathological hallmarks of several neurodegenerative disorders, including Alzheimer's disease (AD). NFTs are composed of microtubule-binding protein tau, which assembles to form paired helical filaments (PHFs) and straight filaments.
Yuko Saito, Miyuki Murayama, Shigeo Murayama, Yuji Yoshiike, Sumihiro Maeda, Hyonchol Kim, Hyonchol Kim, and Atsushi Ikai, Tomohiro Miyasaka, Naruhiko Sahara, Akihiko Takashima   +10 more
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Modulation of tau pathology in tau transgenic models

Biochemical Society Transactions, 2010
NFTs (neurofibrillary tangles) in Alzheimer's disease and in tauopathies are hallmark neuropathological lesions whose relationship with neuronal dysfunction, neuronal death and with other lesions [such as Aβ (amyloid β-peptide) pathology] are still imperfectly understood.
Brion, Jean Pierre, Ando, Kunie, Heraud, Céline, Leroy, Karelle   +3 more
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Search for CP violation in Z-]tau-tau

1992
Using the 18.8 pb-1 of data accumulated at LEP in 1990 and 1991 with the ALEPH detector, a direct test of neutral current CP-invariance is performed by a search for CP-odd correlations in Z decays to tau pairs where both tau decay modes are identified. No evidence for CP-violation is observed. The weak dipole moment of the tau has been measured to be d(
BUSKULIC D, DECAMP D, GOY C, LEES JP, MINARD MN, MOURS B, ALEMANY R, ARIZTIZABAL F, COMAS P, CRESPO JM, DELFINO M, FERNANDEZ E, GAITAN V, GARRIDO L, MATTISON T, PACHECO A, PASCUAL A, CREANZA D, DEPALMA M, FARILLA A, IASELLI G, MAGGI G, MAGGI M, NATALI S, NUZZO S, QUATTROMINI M, RANIERI A, RASO G, ROMANO F, RUGGIERI F, SELVAGGI G, SILVESTRIS L, TEMPESTA P, ZITO G, HU H, HUANG D, HUANG X, LIN J, LOU J, QIAO C, WANG T, XIE Y, XU D, XU R, ZHANG J, ZHAO W, BAUERDICK LAT, BLUCHER E, BONVICINI G, BOSSI F, BOUDREAU J, CASPER D, DREVERMANN H, FORTY RW, GANIS G, GAY C, HAGELBERG R, HARVEY J, HAYWOOD S, HILGART J, JACOBSEN R, JOST B, KNOBLOCH J, LANCON E, LEHRAUS I, LOHSE T, LUSIANI, Alberto, MARTINEZ M, MATO P, MEINHARD H, MINTEN A, MIQUEL R, MOSER HG, PALAZZI P, PERLAS JA, PUSZTASZERI JF, RANJARD F, REDLINGER G, ROLANDI, LUIGI, ROTHBERG J, RUAN T, SAICH M, SCHLATTER D, SCHMELLING M, SEFKOW F, TEJESSY W, WACHSMUTH H, WIEDENMANN W, WILDISH T, WITZELING W, WOTSCHACK J, AJALTOUNI Z, BADAUD F, BARDADINOTWINOWSKA M, BENCHEIKH AM, ELFELLOUS R, FALVARD A, GAY P, GUICHENEY C, HENRARD P, JOUSSET J, MICHEL B, MONTRET JC, PALLIN D, PERRET P, PIETRZYK B, PRORIOL J, PRULHIERE F, STIMPFL G, FEARNLEY T, HANSEN JD, HANSEN JR, HANSEN PH, MOLLERUD R, NILSSON BS, EFTHYMIOPOULOS I, KYRIAKIS A, SIMOPOULOU E, VAYAKI A, ZACHARIADOU K, BADIER J, BLONDEL A, BONNEAUD G, BRIENT JC, FOUQUE G, ORTEU S, ROSOWSKY A, ROUGE A, RUMPF M, TANAKA R, VERDERI M, VIDEAU H, CANDLIN DJ, PARSONS MI, VEITCH E, MONETA L, PARRINI G, CORDEN M, GEORGIOPOULOS C, IKEDA M, LANNUTTI J, LEVINTHAL D, MERMIKIDES M, SAWYER L, WASSERBAECH S, ANTONELLI A, BALDINI R, BENCIVENNI G, BOLOGNA G, CAMPANA P, CAPON G, CERUTTI F, CHIARELLA V, DETTORREPIAZZOLI B, FELICI G, LAURELLI P, MANNOCCHI G, MURTAS F, MURTAS GP, PASSALACQUA L, PEPEALTARELLI M, PICCHI P, ALTOON B, BOYLE O, COLRAIN P, TENHAVE I, LYNCH JG, MAITLAND W, MORTON WT, RAINE C, SCARR JM, SMITH K, THOMPSON AS, TURNBULL RM, BRANDL B, BRAUN O, FISCHER T, GEWENIGER C, HANKE P, HEPP V, KLUGE EE, MAUMARY Y, PUTZER A, RENSCH B, STAHL A, TITTEL K, WUNSCH M, BELK AT, BEUSELINCK R, BINNIE DM, CAMERON W, CATTANEO M, COLLING DJ, DORNAN PJ, DUGEAY S, GREENE AM, HASSARD JF, LIESKE NM, NASH J, PATTON SJ, BATIGNANI G, FORTI F, LIGABUE, FRANCO, TRIGGIANI G, RAGUSA F   +204 more
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The spectroscopic binary tau Tau.

Publications of the Astronomical Society of the Pacific, 1961
E. G. Ebbighausen, R. M. Petrie
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Tau-p or Not Tau-p?

59th EAGE Conference & Exhibition, 1997
V. Dirks, R.H. Evans, P.B. Dillon
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