Results 101 to 110 of about 243,600 (356)
Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease [PDF]
, 2021 Tao Zhang +12 more
openalex +1 more source
Advanced Functional Materials, EarlyView.This review highlights recent advances in label‐free optical biosensors based on 2D materials and rationally designed mixed‐dimensional nanohybrids, emphasizing their synergistic effects and novel functionalities. It also discusses multifunctional sensing platforms and the integration of machine learning for intelligent data analysis.
Xinyi Li, Yonghao Fu, Yuehe Lin, Dan Du
wiley +1 more source
Advanced Functional Materials, EarlyView.A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu +8 more
wiley +1 more source
, 2015 The Identification of the influential nodes in networks is one of the most promising domains. In this paper, we present an improved iterative resource allocation (IIRA) method by considering the centrality information of neighbors and the influence of ...
Liu, Jian-Guo +2 more
core +1 more source
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. [PDF]
, 2015 Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at ...
Andreas Weiss +16 more
core +1 more source
pH‐Tunable Material Properties of Glycine‐Rich Condensates from Tick Bioadhesive
Advanced Functional Materials, EarlyView.This work studies the influence of pH on the phase separation behavior of a disordered glycine‐rich protein found in tick bioadhesive. The results show profound impact on the propensity of coacervation, condensate microstructure and viscosity, amphiphilicity of the peptides, and effective encapsulation of therapeutic molecules.
Manali Nandy +5 more
wiley +1 more source
Contraction of cross-linked actomyosin bundles
, 2012 Cross-linked actomyosin bundles retract when severed in vivo by laser ablation, or when isolated from the cell and micromanipulated in vitro in the presence of ATP.
Bonnet I +12 more
core +1 more source
Total and phosphorylated tau proteins: Evaluation as core biomarker candidates in frontotemporal dementia [PDF]
, 2004 An ever increasing number of patients with neurodegenerative disorders calls for the evaluation of potential diagnostic markers that allow an early diagnosis and an early initiation of specific therapy. Clinical diagnosis of Alzheimer's disease (AD), the
Hampel, H., Teipel, S. J.
core +1 more source
Identification of the three zinc-binding sites on Tau protein [PDF]
, 2021 Romain La Rocca +7 more
openalex +1 more source
Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore
Advanced Functional Materials, EarlyView.To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul +8 more
wiley +1 more source