Results 121 to 130 of about 243,600 (356)
Advanced Functional Materials, EarlyView.Hybrid magnetic microdiscs with customizable size and composition are engineered through refined photolithography and LbL assembly. Embedded Fe3O4 nanoparticles enable localized, non‐cytotoxic heating, while protein cargos can be incorporated in tunable quantities.
Daniela Iglesias‐Rojas +13 more
wiley +1 more source
The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic Target
Scientifica, 2012 The abnormal deposition of proteins in and around neurons is a common pathological feature of many neurodegenerative diseases. Among these pathological proteins, the microtubule-associated protein tau forms intraneuronal filaments in a spectrum of ...
Michael S. Wolfe
doaj +1 more source
Tangles, toxicity, and tau secretion in AD – new approaches to a vexing problem
Frontiers in Neurology, 2013 When the microtubule-associated protein tau is not bound to axonal microtubules (MTs), it becomes hyperphosphorylated and vulnerable to proteolytic cleavage and other changes typically seen in the hallmark tau deposits (neurofibrillary tangles) of tau ...
Kerry eGendreau, Garth F Hall
doaj +1 more source
Alzheimer's disease: β‐Amyloid protein and tau [PDF]
, 2002 Maho Morishima‐Kawashima, Yasuo Ihara
openalex +1 more source
Advanced Functional Materials, EarlyView.Nanoscale‐grooved indium gallium oxide (IGO) semiconductors, patterned via thermal nanoimprint lithography (NIL) using CD/DVD templates, are integrated into electrolyte‐gated transistor biosensors to overcome Debye length limitations. Precisely engineered concave–convex nanostructures modulate local electrostatic potentials, extend the effective Debye ...
Jong Yu Song +5 more
wiley +1 more source
AIMS Molecular Science, 2015 Since hyperphosphorylation of protein tau is a crucial event in Alzheimer’s disease, additional mechanisms besides the interplay of kinase and phosphatase activities are investigated, such as the effect of the peptidyl prolyl cis/trans isomerase Pin1 ...
Ann De Vos +8 more
doaj +1 more source
Pioglitazone Ameliorates Intracerebral Insulin Resistance and Tau-protein Hyperphosphorylation in Rats with Type 2 Diabetes [PDF]
, 2013 Shengqing Hu +3 more
openalex +1 more source
Bioprinting Organs—Science or Fiction?—A Review From Students to Students
Advanced Healthcare Materials, EarlyView.Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu +18 more
wiley +1 more source
Compression‐Tension‐Asymmetry and Stiffness Nonlinearity of Collagen‐Matrigel Composite Hydrogels
Advanced Healthcare Materials, EarlyView.Self‐assembled collagen hydrogel matrices are widely used in tissue engineering applications. These matrices stiffen and contract laterally under tension due to fiber alignment and soften and collapse under compression due to fiber buckling. It is demonstrated that filler materials, such as Matrigel, linearize the mechanical behavior of collagen ...
David Böhringer +9 more
wiley +1 more source