Results 151 to 160 of about 243,600 (356)

Utilizing neurodegenerative markers for the diagnostic evaluation of amyotrophic lateral sclerosis

European Journal of Medical Research
Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive deterioration of upper and lower motor neurons.
Kateřina Klíčová, Jan Mareš, Kateřina Menšíková, Michaela Kaiserová, David Friedecký, Petr Kaňovský, Miroslav Strnad, Radoslav Matěj   +7 more
doaj   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines

Research and Reports in Urology, 2017
Jian Yang,1,2,* Yang Yu,1,* Wei Liu,2 Zhi Li,2 Zhongqing Wei,2 Rongjiang Jiang1,2 1The Second Clinical Medical College of Nanjing Medical University, 2Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu ...
Yang J, Yu Y, Liu W, Liu W, Li Z, Wei ZQ, Jiang R   +6 more
doaj  

Linked CSF reduction of phosphorylated tau and IL-8 in HIV associated neurocognitive disorder. [PDF]

, 2019
HIV-associated neurocognitive disorder (HAND) is a common condition in both developed and developing nations, but its cause is largely unknown. Previous research has inconsistently linked Alzheimer's disease (AD), viral burden, and inflammation to the ...
Anderson, Albert M, Christina Howell, J, Franklin, Donald, Hu, William T, Kollhoff, Alexander, Letendre, Scott, Loring, David W, Ozturk, Tugba, Tyor, William R, Waldrop-Valverde, Drenna   +9 more
core   +1 more source

Discriminating between native and phosphorylated tau proteins using fluid‐lipid bilayer‐coated nanopores [PDF]

Saurabh Awasthi, Michael Mayer
openalex   +1 more source

A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s Disease [PDF]

, 2018
Rubayat Khan, Saif Nirzhor, Barnaly Rashid   +2 more
openalex   +1 more source

Modulus‐Switchable Miniature Robots for Biomedical Applications: A Review

Advanced Robotics Research, EarlyView.
Materials, robot designs, proof‐of‐concept functions, and biomedical applications of modulus‐switchable miniature robots. Miniature soft robots have shown great potential in biomedical applications due to their excellent controllability and suitable mechanical properties in biological environments.
Chunyun Wei, Yibin Wang, Jiangfan Yu
wiley   +1 more source

Severe Gestational Low-Protein Intake Impacts Hippocampal Cellularity, Tau, and Amyloid-β Levels, and Memory Performance in Male Adult Offspring: An Alzheimer-Simile Disease Model?

, 2021
Gabriel Boer Grigoletti-Lima, Marcelo Gustavo Lopes, Ana Tereza Barufi Franco, Aparecida Marcela Damico, Patrìcia Aline Boer, José Antonio Rocha Gontijo   +5 more
openalex   +2 more sources

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Tau modulation through AAV9 therapy augments Akt/Erk survival signalling in glaucoma mitigating the retinal degenerative phenotype

Acta Neuropathologica Communications
The microtubule-associated protein Tau is a key player in various neurodegenerative conditions, including Alzheimer's disease (AD) and Tauopathies, where its hyperphosphorylation disrupts neuronal microtubular lattice stability.
Kanishka Pushpitha Maha Thananthirige, Nitin Chitranshi, Devaraj Basavarajappa, Rashi Rajput, Mojdeh Abbasi, Viswanthram Palanivel, Veer Bala Gupta, Joao A. Paulo, Maya Koronyo-Hamaoui, Mehdi Mirzaei, Stuart L. Graham, Vivek Gupta   +11 more
doaj   +1 more source