Results 221 to 230 of about 243,600 (356)

[Tau protein and beta protein].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1990
The main pathological features of Alzheimer's disease are Alzheimer neurofibrillary tangles and senile plaques. Recent biochemical research revealed that tangles are composed of tau protein and ubiquitin and amyloid in senile plaques is composed of beta protein which is a fragment of the membrane receptor protein.
openaire   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice. [PDF]

Cell Rep
Martín-Ávila A, Modak SR, Rajamohamedsait HB, Dodge A, Shamir DB, Krishnaswamy S, Sandusky-Beltran LA, Walker M, Lin Y, Congdon EE, Sigurdsson EM.   +10 more
europepmc   +1 more source

Human MAP Tau Based Targeted Cytolytic Fusion Proteins [PDF]

, 2017
Olusiji Akinrinmade, Sandra Jordaan, Dmitrij Hristodorov, Radoslav Mladenov, Neelakshi Mungra, Shivan Chetty, Stefan Barth   +6 more
openalex   +1 more source

Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes

Advanced Science, EarlyView.
Mid‐infrared photothermal microscopy enables label‐free structural, molecular, and functional imaging of protein aggregates in astrocyte cells. The processes of astrocytes differentiated on a nanomaterial interface are characterized by α‐helical signatures combined with enhanced interfacial thermal resistance properties, while the cell soma of non ...
Panagis D. Samolis, Chiara Lazzarini, Rahmetullah Durgun, Barbara Barile, Giorgia Conte, Tamara Posati, Marco Caprini, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander   +9 more
wiley   +1 more source

Neurons ensheathed by perineuronal nets are prone to hyperphosphorylation of tau protein in the hibernating Syrian hamster brain. [PDF]

Sci Rep
Berrouschot V, Sonntag M, Reimann K, Jäger C, Martin S, Holzer M, Stieler JT, Morawski M.   +7 more
europepmc   +1 more source

Isoflurane-induced spatial memory impairment by a mechanism independent of amyloid-beta levels and tau protein phosphorylation changes in aged rats

, 2011
Weiran Liu, Jie Xu, Hui Wang, Chengshi Xu, Chao Ji, Yun Wang, Chunsheng Feng, Xuena Zhang, Zhipeng Xu, Anshi Wu, Zhongcong Xie, Yun Yue   +11 more
openalex   +2 more sources

cDC1 Subtype‐Specific In Vivo Targeting of Liposomes

Advanced Science, EarlyView.
Dendritic cells, particularly the cDC1 subtype, offer a promising target for drug delivery via liposomes due to their pivotal role in immune regulation, allowing for amplified therapeutic responses. Herein, we show an integration of physicochemical characterization and cell experiments to achieve effective in vivo cDC1 targeting through anti‐CLEC9A ...
Maximilian Schaaf, Michael Fichter, Lin Jian, Felicia Schön, Carina Jung, Paul Schneider, Kai Speth, Ana Mateos‐Maroto, Volker Mailänder, Kaloian Koynov, Svenja Morsbach, Katharina Landfester   +11 more
wiley   +1 more source

Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease.

, 1990
Maria Grazia Spillantini, Michel Goedert, Ross Jakes, A. Klug   +3 more
openalex   +2 more sources

Neurons expressing pathological Tau protein trigger dramatic changes in microglial morphology and dynamics [PDF]

, 2019
Rahma Hassan-Abdi, Alexandre Brenet, Mohamed Bennis, Constantin Yanicostas, Nadia Soussi-Yanicostas   +4 more
openalex   +1 more source