Results 251 to 260 of about 243,600 (356)

Multiple and Alternative Sites Make Tau Protein an Adaptable Sticky Surface for the SH3 Domain of Fyn Kinase. [PDF]

Angew Chem Int Ed Engl
Tira R, Leo G, Prandini L, Barracchia CG, D'Onofrio M, Mollica L, Capaldi S, Assfalg M, Munari F.   +8 more
europepmc   +1 more source

Structural Study of the Microtubule-associated Protein Tau Locus of Alzheimer′s disease in Taiwan

, 2013
Hon‐Chung Fung, Chun‐Wei Chang, Wen‐Chuin Hsu, Alan Pittman, Yih-Ru Wu, John Hardy   +5 more
openalex   +1 more source

CACLENS: A Multitask Deep Learning System for Enzyme Discovery

Advanced Science, EarlyView.
CACLENS, a multimodal and multi‐task deep learning framework integrating cross‐attention, contrastive learning, and customized gate control, enables reaction type classification, EC number prediction, and reaction feasibility assessment. CACLENS accelerates functional enzyme discovery and identifies efficient Zearalenone (ZEN)‐degrading enzymes.
Xilong Yi, Yingzhu Tan, Huikang Lin, Guoqing Zhang, Ye Tian, Aibo Wu   +5 more
wiley   +1 more source

The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation. [PDF]

Elife
Qi W, Long Y, Li Z, Zhao Z, Shi J, Xie W, Wang L, Tan Y, Zhou T, Liang M, Jiang P, Jiang B, Yang X, Gao G.   +13 more
europepmc   +1 more source

Inferring Gene Regulatory Networks From Single‐Cell RNA Sequencing Data by Dual‐Role Graph Contrastive Learning

Advanced Science, EarlyView.
RegGAIN is a novel and powerful deep learning framework for inferring gene regulatory networks (GRNs) from single‐cell RNA sequencing data. By integrating self‐supervised contrastive learning with dual‐role gene representations, it consistently outperforms existing methods in both accuracy and robustness.
Qiyuan Guan, Jiating Yu, Jieyi Pan, Fan Yuan, Jiadong Ji, Rusong Zhao, Zhi‐Ping Liu, Bingqiang Liu, Ling‐Yun Wu, Duanchen Sun   +9 more
wiley   +1 more source

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Neuron-specific enolase and Tau protein as biomarkers for sepsis-associated delirium: a cross-sectional pilot study. [PDF]

Einstein (Sao Paulo)
Pinto AAS, Carvalho MM, Santos JB, Silva RSD, Barbeiro HV, Gómez LMG, Maia IWA, Marchini JFM, Garcez FB, Avelino-Silva TJ, Soler LM, Mochetti MM, Souza HP, Alencar JCG.   +13 more
europepmc   +1 more source