Results 301 to 310 of about 243,600 (356)

Amyloid-beta and tau protein beyond Alzheimer's disease. [PDF]

Neural Regen Res
Abyadeh M, Gupta V, Paulo JA, Mahmoudabad AG, Shadfar S, Mirshahvaladi S, Gupta V, Nguyen CTO, Finkelstein DI, You Y, Haynes PA, Salekdeh GH, Graham SL, Mirzaei M.   +13 more
europepmc   +1 more source

Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure. [PDF]

Int J Mol Sci
Pena E, San Martin-Salamanca R, El Alam S, Flores K, Arriaza K.   +4 more
europepmc   +1 more source

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Tau protein and tau aggregation inhibitors

Neuropharmacology, 2010
Alzheimer disease is characterized by pathological aggregation of two proteins, tau and Abeta-amyloid, both of which are considered to be toxic to neurons. In this review we summarize recent advances on small molecule inhibitors of protein aggregation with emphasis on tau, with activities mediated by the direct interference of self-assembly.
Bulic, B., Pickhardt, M., Mandelkow, E., Mandelkow, E.   +3 more
openaire   +3 more sources

Phosphorylation of tau protein in tau-transfected 3T3 cells

Molecular Brain Research, 1993
The tau protein of Alzheimer paired helical filaments (PHFs) is aberrantly phosphorylated, as evidenced by its reactivity with several phosphate-dependent antibodies. We sought to identify whether this unusual phosphorylation state exists in tau expressed by transfected NIH 3T3 fibroblasts. Immunoblot analysis of cell clones transfected with constructs
L A, Sygowski, A W, Fieles, M M, Lo, C W, Scott, C B, Caputo   +4 more
openaire   +2 more sources

Tau Protein and Zebrafish Models for Tau-Induced Neurodegeneration

Journal of Alzheimer's Disease, 2019
Tauopathies are a specific type of slow and progressive neurodegeneration, which involves intracellular deposition of fibrillar material composed of abnormal hyperphosphorylation of the microtubule associated protein (MAP) tau. Despite many years of intensive research, our understanding of the molecular events that lead to neurodegeneration is far from
Yuanting, Ding, Lijuan, Lei, Chencen, Lai, Zhi, Tang   +3 more
openaire   +2 more sources

Tau protein

1999
Abstract A synonymous name is MAPT, but it is not commonly used (only in GeneCards and OMIM databases, see below). There are several homologous proteins, recognized by common sequence motifs in the repeat domain (see below).
Peter Friedhoff, Eckhard Mandelkow
openaire   +1 more source