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Tau protein and neurodegeneration
Molecular Neurobiology, 1990Many of the human neurodegenerative conditions involve a reorganization of the neuronal cytoskeleton. The way in which the cytoskeleton is reorganized may provide a clue to the nature of the insult causing the neurodegeneration. The most common of these conditions is Alzheimer's disease, in which microtubules are lost from neurites that fill up with ...
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Tau protein and neurodegeneration
Seminars in Cell & Developmental Biology, 2004Tau protein is the major component of the intracellular filamentous deposits that define a number of neurodegenerative diseases. They include the largely sporadic Alzheimer's disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease (PiD), argyrophilic grain disease, as well as the inherited frontotemporal dementia ...
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Tau Protein and Frontotemporal Dementias
2021Filamentous inclusions of tau protein are found in cases of inherited and sporadic frontotemporal dementias (FTDs). Mutations in MAPT, the tau gene, cause approximately 5% of cases of FTD. They proved that dysfunction of tau protein is sufficient to cause neurodegeneration and dementia.
Michel, Goedert +7 more
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Tau protein and Alzheimer's disease
Neurobiology of Aging, 1994The etiology of Alzheimer's disease is still unknown. Because the disease is specific for human brain, a rational search for early diagnosis or prevention is very difficult. This calls for the development of cellular models that mimick the degeneration of neurons in AD.
E M, Mandelkow, E, Mandelkow
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2017
This detailed volume gathers basic and advanced methods and protocols from in vitro assays and in vivo models to address the molecular and functional aspects of tau physiopathology. Divided into five parts that illustrate the underlying molecular mechanisms of Tau functions and dysfunctions in Alzheimer’s disease and other dementia referred to as ...
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This detailed volume gathers basic and advanced methods and protocols from in vitro assays and in vivo models to address the molecular and functional aspects of tau physiopathology. Divided into five parts that illustrate the underlying molecular mechanisms of Tau functions and dysfunctions in Alzheimer’s disease and other dementia referred to as ...
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Hirano bodies contain tau protein
Brain Research, 1987Hirano bodies are intraneuronal inclusions whose frequency increases with age and Alzheimer's disease. These paracrystalline inclusions have been shown previously using immunocytochemistry to share epitopes with actin, tropomyosin, alpha-actinin and vinculin.
P G, Galloway +3 more
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ACS Chemical Neuroscience, 2020
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases without any effective medicine treatments. The neurofibrillary tangles containing hyperphosphorylated tau protein are one important pathological characteristic. Thus, one practicable strategy for AD drug design is to discover compounds that could inhibit tau protein ...
Shifeng Xiao +7 more
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Alzheimer's disease (AD) is one of the most common neurodegenerative diseases without any effective medicine treatments. The neurofibrillary tangles containing hyperphosphorylated tau protein are one important pathological characteristic. Thus, one practicable strategy for AD drug design is to discover compounds that could inhibit tau protein ...
Shifeng Xiao +7 more
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Cytoskeleton, 2023
AbstractIn January of this year I received an unexpected request from George Bloom to contribute an historical perspective on “the discovery of tau protein,” an event that occurred roughly 50 years ago. My first thought was that it could not have been that long ago, as the memories of what was my first independent scientific discovery are still fresh ...
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AbstractIn January of this year I received an unexpected request from George Bloom to contribute an historical perspective on “the discovery of tau protein,” an event that occurred roughly 50 years ago. My first thought was that it could not have been that long ago, as the memories of what was my first independent scientific discovery are still fresh ...
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Chemical & Engineering News Archive, 2012
Researchers in Germany have developed a method for producing a synthetic version of tau protein labeled with phosphate at a specific site. Being able to make a full version of tau—one of the main actors in Alzheimer’s disease—and to chemically modify it at a specific amino acid site should help scientists uncover more about the mechanism by which tau’s
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Researchers in Germany have developed a method for producing a synthetic version of tau protein labeled with phosphate at a specific site. Being able to make a full version of tau—one of the main actors in Alzheimer’s disease—and to chemically modify it at a specific amino acid site should help scientists uncover more about the mechanism by which tau’s
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Journal of Neuroscience Research, 1992
AbstractExpression of tau protein in non‐neuronal cells can result in a redistribution of the microtubule cytoskeleton into thick bundles of tau‐containing microtubules (Lewis et al.: Nature 342:498–505, 1989; Kanai et al.: J Cell Biol 109:1173–1184, 1989).
C W, Scott +4 more
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AbstractExpression of tau protein in non‐neuronal cells can result in a redistribution of the microtubule cytoskeleton into thick bundles of tau‐containing microtubules (Lewis et al.: Nature 342:498–505, 1989; Kanai et al.: J Cell Biol 109:1173–1184, 1989).
C W, Scott +4 more
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