Results 291 to 300 of about 5,828,673 (370)

Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation

, 2001
Jin G. Sheng, Richard A. Jones, Xue Zhou, John M. McGinness, Linda J. Van Eldik, Robert E. Mrak, W. Sue T. Griffin   +6 more
openalex   +2 more sources

A Reaction‐Diffusion Frame for Accessing Metabolic O2 Fluxes in Single Microalgal Cells with Low‐Cost Wide‐Field Imaging of Nanosensor Luminescence Lifetime

Advanced Science, EarlyView.
Individual Chlamydomonas reinhardtii (C. reinhardtii) living cells on an agarose pad containing luminescent O2 nanosensors are imaged with a simple wide‐field protocol of lifetime imaging. The resulting maps of phosphorescence lifetime are analyzed within a reaction‐diffusion frame to access the distribution of metabolic O2 fluxes generated by single ...
Hélène Merceron, Eliora Israelievitch, Valentine Rollot, Théo Villarubias, Xiaojiang Xie, Thomas Le Saux, Karim Benzerara, François Guyot, Alix Boulouis, Emmanuelle Marie‐Bègue, Laurent Thouin, Ludovic Jullien   +11 more
wiley   +1 more source

Coexpression of Human cdk5 and Its Activator p35 with Human Protein Tau in Neurons in Brain of Triple Transgenic Mice

, 2001
Chris Van den Haute, Kurt Spittaels, Jo Van Dorpe, Reena Lasrado, Kris Vandezande, Isabelle Laenen, Hugo Geerts, F. Van Leuven   +7 more
openalex   +2 more sources

Mechanical Force Storage and Reprogramming Hydrogel for Scarless Repair of Sports Joint Wounds

Advanced Science, EarlyView.
Inspired by the energy conversion of tendons, the “energy transit station” hydrogel is designed. The hydrogel not only shields stress concentration in sports injuries, but also reprograms energy forms to provide reasonable biomimetic contraction for wounds.
Jiakang Zhang, Yuhui Zhang, Yuanru Lang, Tao Fu, Qian Liu, Long Chen, Peng Zhang, Yan Xiao, Yuntong Zhang, Shuo Fang, Meidong Lang   +10 more
wiley   +1 more source

Dissecting the Molecular Determinants of α‐synuclein Phase Separation and Condensate Aging: The Pivotal Role of β‐Sheet‐Rich Motifs

Advanced Science, EarlyView.
Through multiscale simulations and experimental approaches, the molecular determinants of α‐synuclein phase separation and condensate aging, which are linked to Parkinson's disease, are uncovered. Seven motifs are identified with high β‐sheet propensity in monomeric α‐synuclein and increasing β‐sheet tendencies during condensation and pre ...
Yiming Tang, Jitao Wen, Zhongyuan Yang, Yifei Yao, Shaoshuai He, Jiyuan Zeng, Xuewei Dong, Qin Qiao, Yun Zhou, Sarah Perrett, Si Wu, Guanghong Wei   +11 more
wiley   +1 more source

Alzheimer's diagnosis beyond cerebrospinal fluid: Probe-Free Detection of Tau Proteins using MXene based redox systems and molecularly imprinted polymers.

Biosens Bioelectron X
Arjun AM, Deshpande S, Dunlop T, Norman B, Oliviera D, Vulpe G, Moreira F, Sharma S.   +7 more
europepmc   +1 more source

Filamentous Aggregates of Tau Proteins Fulfil Standard Amyloid Criteria Provided by the Fuzzy Oil Drop (FOD) Model. [PDF]

Int J Mol Sci, 2018
Dułak D, Gadzała M, Banach M, Ptak M, Wiśniowski Z, Konieczny L, Roterman I.   +6 more
europepmc   +1 more source

A Single‐Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration

Advanced Science, EarlyView.
Herein, guanidinium‐modified calix[5]arene (GC5AY) is developed featuring small size, positive charge, and desirable amphiphilicity, that can efficiently traverse the nasal mucosal barrier for brain drug delivery. Additionally, possessing inherent therapeutic functions, GC5AY can thus serve as a single‐molecule pleuripotent scaffold for multi‐target ...
Jian‐Mei Gao, Wen‐Bo Li, Na‐Na Chen, Yang Yi, Ze‐Han Wang, Xian Chen, Yang‐Yang Zhao, Ze‐Li Yuan, Jie Gao, Yu‐Chen Pan, Dong‐Sheng Guo, Qi‐Hai Gong   +11 more
wiley   +1 more source

Millikelvin Intracellular Nanothermometry with Nanodiamonds

Advanced Science, EarlyView.
Nanothermometry in living cells is crucial for understanding heat diffusion and advancing cellular biology and drug discovery. Previous studies have reported controversial intracellular temperature variations. Using nanodiamond nanothermometry in macrophages, it is found that, in such experimental setting, apparent temperature changes are actually due ...
Maabur Sow, Jacky Mohnani, Genko Genov, Raphael Klevesath, Elisabeth Mayerhoefer, Yuliya Mindarava, Rémi Blinder, Soumen Mandal, Fabien Clivaz, Raúl B. Gonzalez, Daniel Tews, Christian Laube, Wolfgang Knolle, Amelie Jerlitschka, Farid Mahfoud, Oleg Rezinkin, Mateja Prslja, Yingke Wu, Pamela Fischer‐Posovszky, Martin B. Plenio, Susana F. Huelga, Tanja Weil, Anke Krueger, Gavin W. Morley, Oliver A. Williams, Steffen Stenger, Fedor Jelezko   +26 more
wiley   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source