Results 331 to 340 of about 5,909,902 (374)

Label-free optical observation of disordered-to-ordered transitions in single intrinsically disordered proteins

Zargarbashi S, Dominguez C, Peters M, Yousefi A, Munday S, Wang Y, Chatterjee S, Hudson A, Gordon R, Mellor CJ, Xu L, Rahmani M, Ying C.   +12 more
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Tau protein and tau aggregation inhibitors

Neuropharmacology, 2010
Alzheimer disease is characterized by pathological aggregation of two proteins, tau and Abeta-amyloid, both of which are considered to be toxic to neurons. In this review we summarize recent advances on small molecule inhibitors of protein aggregation with emphasis on tau, with activities mediated by the direct interference of self-assembly.
Bulic, B., Pickhardt, M., Mandelkow, E., Mandelkow, E.   +3 more
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Phosphorylation of tau protein in tau-transfected 3T3 cells

Molecular Brain Research, 1993
The tau protein of Alzheimer paired helical filaments (PHFs) is aberrantly phosphorylated, as evidenced by its reactivity with several phosphate-dependent antibodies. We sought to identify whether this unusual phosphorylation state exists in tau expressed by transfected NIH 3T3 fibroblasts. Immunoblot analysis of cell clones transfected with constructs
L A, Sygowski, A W, Fieles, M M, Lo, C W, Scott, C B, Caputo   +4 more
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Tau Protein and Zebrafish Models for Tau-Induced Neurodegeneration

Journal of Alzheimer's Disease, 2019
Tauopathies are a specific type of slow and progressive neurodegeneration, which involves intracellular deposition of fibrillar material composed of abnormal hyperphosphorylation of the microtubule associated protein (MAP) tau. Despite many years of intensive research, our understanding of the molecular events that lead to neurodegeneration is far from
Yuanting, Ding, Lijuan, Lei, Chencen, Lai, Zhi, Tang   +3 more
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Tau protein

1999
Abstract A synonymous name is MAPT, but it is not commonly used (only in GeneCards and OMIM databases, see below). There are several homologous proteins, recognized by common sequence motifs in the repeat domain (see below).
Peter Friedhoff, Eckhard Mandelkow
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Tau protein and neurodegeneration

Molecular Neurobiology, 1990
Many of the human neurodegenerative conditions involve a reorganization of the neuronal cytoskeleton. The way in which the cytoskeleton is reorganized may provide a clue to the nature of the insult causing the neurodegeneration. The most common of these conditions is Alzheimer's disease, in which microtubules are lost from neurites that fill up with ...
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Tau protein and neurodegeneration

Seminars in Cell & Developmental Biology, 2004
Tau protein is the major component of the intracellular filamentous deposits that define a number of neurodegenerative diseases. They include the largely sporadic Alzheimer's disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease (PiD), argyrophilic grain disease, as well as the inherited frontotemporal dementia ...
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Tau Protein and Frontotemporal Dementias

2021
Filamentous inclusions of tau protein are found in cases of inherited and sporadic frontotemporal dementias (FTDs). Mutations in MAPT, the tau gene, cause approximately 5% of cases of FTD. They proved that dysfunction of tau protein is sufficient to cause neurodegeneration and dementia.
Michel, Goedert, Maria Grazia, Spillantini, Benjamin, Falcon, Wenjuan, Zhang, Kathy L, Newell, Masato, Hasegawa, Sjors H W, Scheres, Bernardino, Ghetti   +7 more
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Tau protein and Alzheimer's disease

Neurobiology of Aging, 1994
The etiology of Alzheimer's disease is still unknown. Because the disease is specific for human brain, a rational search for early diagnosis or prevention is very difficult. This calls for the development of cellular models that mimick the degeneration of neurons in AD.
E M, Mandelkow, E, Mandelkow
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Tau Protein

2017
This detailed volume gathers basic and advanced methods and protocols from in vitro assays and in vivo models to address the molecular and functional aspects of tau physiopathology. Divided into five parts that illustrate the underlying molecular mechanisms of Tau functions and dysfunctions in Alzheimer’s disease and other dementia referred to as ...
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