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Journal of Neuroscience Research, 1992
AbstractExpression of tau protein in non‐neuronal cells can result in a redistribution of the microtubule cytoskeleton into thick bundles of tau‐containing microtubules (Lewis et al.: Nature 342:498–505, 1989; Kanai et al.: J Cell Biol 109:1173–1184, 1989).
Mathew M.S. Lo +4 more
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AbstractExpression of tau protein in non‐neuronal cells can result in a redistribution of the microtubule cytoskeleton into thick bundles of tau‐containing microtubules (Lewis et al.: Nature 342:498–505, 1989; Kanai et al.: J Cell Biol 109:1173–1184, 1989).
Mathew M.S. Lo +4 more
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Tau protein and neurodegeneration
Molecular Neurobiology, 1990Many of the human neurodegenerative conditions involve a reorganization of the neuronal cytoskeleton. The way in which the cytoskeleton is reorganized may provide a clue to the nature of the insult causing the neurodegeneration. The most common of these conditions is Alzheimer's disease, in which microtubules are lost from neurites that fill up with ...
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Tau protein and neurodegeneration
Seminars in Cell & Developmental Biology, 2004Tau protein is the major component of the intracellular filamentous deposits that define a number of neurodegenerative diseases. They include the largely sporadic Alzheimer's disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease (PiD), argyrophilic grain disease, as well as the inherited frontotemporal dementia ...
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Tau Protein and Frontotemporal Dementias
2021Filamentous inclusions of tau protein are found in cases of inherited and sporadic frontotemporal dementias (FTDs). Mutations in MAPT, the tau gene, cause approximately 5% of cases of FTD. They proved that dysfunction of tau protein is sufficient to cause neurodegeneration and dementia.
Wenjuan Zhang +7 more
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2017
Alzheimer’s disease (AD) is classically defined by the accumulation of abnormal aggregates mainly comprised of two proteins: phosphorylated tau (ptau) and amyloid beta (Aβ). It has been proposed that those aggregates lead to several cellular changes that are translated into neuronal loss and the impoverishment of cognitive functions.
G. Perry +2 more
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Alzheimer’s disease (AD) is classically defined by the accumulation of abnormal aggregates mainly comprised of two proteins: phosphorylated tau (ptau) and amyloid beta (Aβ). It has been proposed that those aggregates lead to several cellular changes that are translated into neuronal loss and the impoverishment of cognitive functions.
G. Perry +2 more
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Microtubules and the Protein Tau
2014The protein tau is central to the pathological process underlying sporadic AD. It is chiefly a neuronal protein and is produced in all portions of the nervous system (CNS, PNS, ENS) (Trojanowski et al. 1989). In immature nerve cells, tau is distributed diffusely throughout the entire cell, but during cell maturation it converts into a primarily axonal ...
Heiko Braak, Kelly Del Tredici
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Aggregation of tau protein by aluminum
Brain Research, 1993Aluminum has been detected in Alzheimer neurofibrillary tangles, but the significance of its presence is unknown. The principal component of tangles is the paired helical filament (PHF), comprised of tau protein. We investigated whether aluminum could induce tau protein to form filaments or aggregate.
Clay W Scott +3 more
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Chemical & Engineering News Archive, 2012
Researchers in Germany have developed a method for producing a synthetic version of tau protein labeled with phosphate at a specific site. Being able to make a full version of tau—one of the main actors in Alzheimer’s disease—and to chemically modify it at a specific amino acid site should help scientists uncover more about the mechanism by which tau’s
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Researchers in Germany have developed a method for producing a synthetic version of tau protein labeled with phosphate at a specific site. Being able to make a full version of tau—one of the main actors in Alzheimer’s disease—and to chemically modify it at a specific amino acid site should help scientists uncover more about the mechanism by which tau’s
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Modulation of Tau Protein Fibrillization by Oleocanthal
Journal of Natural Products, 2012Among the phenolic compounds extracted from extra virgin olive oil, oleocanthal (1) has attracted considerable attention in the modulation of many human diseases, such as inflammation and Alzheimer's disease (AD). Indeed, 1 is capable of altering the fibrillization of tau protein, which is one of the key factors at the basis of neurodegenerative ...
MONTI, Maria Chiara +3 more
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1990
In aged human brain and particularly in Alzheimer’s disease brain, paired helical filaments (PHF’s) accumulate in the neuronal cells. Recently, it was discovered that tau protein is a component of PHF. Tau protein is one of the brain-specific, microtubule-associated proteins (MAP’s) and promotes the formation of microtubules in vitro and in vivo ...
Kayoko Tomizawa +5 more
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In aged human brain and particularly in Alzheimer’s disease brain, paired helical filaments (PHF’s) accumulate in the neuronal cells. Recently, it was discovered that tau protein is a component of PHF. Tau protein is one of the brain-specific, microtubule-associated proteins (MAP’s) and promotes the formation of microtubules in vitro and in vivo ...
Kayoko Tomizawa +5 more
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