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2014
Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain. The spectrum of tau pathologies expands beyond the traditionally discussed disease forms like Pick disease, progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease. Emerging entities and pathologies include
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Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain. The spectrum of tau pathologies expands beyond the traditionally discussed disease forms like Pick disease, progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease. Emerging entities and pathologies include
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Imaging biomarkers in tauopathies
Parkinsonism & Related Disorders, 2016Abnormally aggregated tau protein is central to the pathophysiology of Alzheimer's disease, frontotemporal dementia variants, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. The post-mortem cortical density of hyperphosphorylated tau tangles correlates with pre-morbid cognitive dysfunction and neuron loss.
Dani, Melanie +2 more
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Neuropathology, 2006
In this symposium, cutting‐edge data on neuropathology, pathological biochemistry and molecular biology of sporadic and familial tauopathies, as well as on the development of model animals, were presented and discussed by five expert neuropathologists.
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In this symposium, cutting‐edge data on neuropathology, pathological biochemistry and molecular biology of sporadic and familial tauopathies, as well as on the development of model animals, were presented and discussed by five expert neuropathologists.
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Anatamopathological spectrum of tauopathies
Movement Disorders, 2003The presence of tau-positive intraneuronal filamentous inclusions with or without additional inclusions in glial cells has been recognised as a major neuropathological feature in a significant group of neurodegenerative diseases, which are described as tauopathies.
Tamas, Revesz, Janice L, Holton
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Frontotemporal dementia and tauopathy
Current Neurology and Neuroscience Reports, 2001The presence of abundant neurofibrillary lesions made of hyperphosphorylated tau proteins is the characteristic neuropathology of a subset of neurodegenerative disorders classified as "tauopathies." The discovery of mutations in the tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) constitutes convincing evidence ...
Y, Yoshiyama, V M, Lee, J Q, Trojanowski
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Treatment Options for Tauopathies
Current Treatment Options in Neurology, 2012To date, there are no approved and established pharmacologic treatment options for tauopathies, a very heterogenous group of neuropsychiatric diseases often leading to dementia and clinically diagnosed as atypical Parkinson syndromes. Among these so-called Parkinson plus syndromes are progressive supranuclear palsy (PSP), also referred to as Steele ...
Tarik, Karakaya +3 more
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Pathogenesis of the Tauopathies
Journal of Molecular Neuroscience, 2011Microtubule-associated protein tau is the most commonly misfolded protein in human neurodegenerative diseases, where it becomes hyperphosphorylated and filamentous. Mutations in MAPT, the tau gene, cause approximately 5% of cases of frontotemporal dementia. They are frequently accompanied by parkinsonism. The existence of MAPT mutations has established
Michel, Goedert +1 more
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Neuropathology of familial tauopathy
Neuropathology, 2006Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP‐17) is a hereditary progressive neurodegenerative disorder. FTDP‐17 was originally defined in Ann Arbor, Michigan, in 1996. Since then, more than 100 families with FTDP‐17 have been described throughout the world, including 18 families identified in Japan.
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New classification of tauopathies
Revue Neurologique, 2018Tauopathies are a group of neurodegenerative diseases characterized by pathological intracellular deposits of the protein tau. Isoform composition, morphology and anatomical distribution of cellular tau-immunoreactivities are defining distinct tauopathies as molecular pathological disease entities.
Höglinger, G. U. +2 more
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Structure-based classification of tauopathies
Nature, 2021Yang Shi, Wenjuan Zhang, Benjamin Falcon
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