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Taxol® Biosynthesis and Production: From Forests to Fermenters [PDF]
, 2017 Taxol® (paclitaxel) has fascinated researchers, medical professionals, politicians and entrepreneurs for almost half a century. Its medicinal value as a potent anti-cancer compound has expanded greatly over time as new applications have been identified for the treatment of diverse indications.
Christopher McElroy, Stefan Jennewein
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Rewiring cellular metabolism for heterologous biosynthesis of Taxol [PDF]
Natural Product Research, 2019 Taxol is one of the anticancer drugs synthesized naturally in the evergreen Taxus brevifolia forest tree belonging to the yew family (Taxaceae) growing on the Pacific. There are reportedly evidence for treating ovarian, breast and lung cancers through this drug given its unique structural and functional features.
Amirhossein Nazhand +5 more
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Sites of biosynthesis and storage of Taxol in Taxus media (Rehder) plants: Mechanism of accumulation
Phytochemistry, 2020Taxol is a cytotoxic agent against various types of cancers. The cytotoxic activities of Taxol can be extended to its synthesizing plant. Here, Taxol is shown to have special synthesis, storage and transport mechanisms that avoid the toxic effects on its source plant.
Sameh S M Soliman
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Acting paths of elicitors on Taxol biosynthesis pathway and their synergistic effect
Biochemical Engineering Journal, 2002Many elicitors have been reported to be favorable to Taxol production in suspension cultures of Taxus cells. However, their acting paths were proved to be different, which were identified based on a quasi-steady-state transfer model. It was found that silver nitrate, ammonium citrate and methyl jasmonic acid acted on the path between Baccatin III and ...
Ying-Jin Yuan, Jin-Chuan Wu
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Preliminary assessment of the C13-side chain 2′-hydroxylase involved in Taxol biosynthesis
Biochemical and Biophysical Research Communications, 2005The biosynthesis of the anticancer drug Taxol in yew (Taxus) species is thought to involve the preliminary formation of the advanced taxane diterpenoid intermediate baccatin III upon which the functionally important N-benzoyl phenylisoserinoyl side chain is subsequently assembled at the C13-O-position.
Rodney Croteau
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Taxol: biosynthesis, molecular genetics, and biotechnological applications
Applied Microbiology and Biotechnology, 2001Over the past decade, Taxol and its closely related structural analogue Taxotere have emerged as very important antitumor agents. Their widespread use in the treatment of a variety of cancer types, their likely approval for the treatment of additional forms of cancer, and their use at earlier stages of intervention will lead to increased demand for ...
S, Jennewein, R, Croteau
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Inspired by taxol: biosynthesis and engineering of hypericin and other phytochemicals in Hypericum
PlantaInsights from paclitaxel research inspire elucidation of hypericin biosynthesis, highlighting gene identification, multi-omics integration, and biotechnological strategies enabling scalable and sustainable production of valuable Hypericum secondary metabolites.
Katarína Bruňáková +3 more
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[Advances and prospects of taxol biosynthesis by endophytic fungi].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2018Taxol is one of the most important chemotherapeutic drugs against cancer. Taxol has been mainly extracted from the bark of yews for a long time. However, methods for the extraction of taxol from the bark of Taxus species were inefficient and environmentally costly.
Kai, Zhao +6 more
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[Study on the effects of salicylic acid on taxol biosynthesis].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2000The influence of salicylic acid on the production of taxanes in plant cell culture was studied. Experimental results showed that addition of salicylic acid at concentration of 0.1 mg/L could enhance the production of taxol to three-fold. The concentration of 10-DAB and baccatin III was also increasing while taxol concentration increases under salicylic
Z Q, Miao, Z J, Wei, Y J, Yuan
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Computational Investigation of Cytochrome P450-Catalyzed Oxetane Formation in Taxol Biosynthesis
BiochemistryPaclitaxel (Taxol) is widely recognized as one of the most effective natural anticancer drugs, yet its production is limited by its scarce natural supply and the low yields obtained from its chemical synthesis. One of the most puzzling steps in its biosynthesis is the formation of the oxetane-containing D-ring, a key structural element necessary for ...
Surajit Nandi +5 more
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