Results 1 to 10 of about 34,731 (182)

Use of endophytic fungi in the Taxol anticancer drug production

Biotecnología Vegetal, 2014
Taxol is a drug used in the chemotherapy of breast, lung, ovarian, prostate, liver cancers, and in the treatment of rheumatoid arthritis. Taxol is obtained from Taxus spp. trees. It is found in low concentrations in the bark, needles and roots.
Hebert Jair Barrales-Cureño, Raqueline de la Rosa Montoya   +1 more
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Enhancement of Taxol production by applying amino acid complex along with chitosan in suspension culture of Taxus baccata L.

Journal of Medicinal Plants, 2020
Background: Taxol (Paclitaxel) has been highly recommended to control and treat a wide range of cancers. Taxus baccata L. is primary and natural origin of Taxol. Objective: Due to severe restriction and prohibition of cutting T.
Bahar Amirkavei Najafabadi, Nasrin Qavami, Mohammad Ali Ebrahimi, Peyman Ebrahimi, Nasim Zarinpanjeh   +4 more
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Synthesis of Ester-linked Taxol-glycoside Conjugate and Its Application to Drug Delivery System Using Immunoliposome Targeted with Trastuzumab and Cetuximab

Natural Product Communications, 2018
Synthesis of ester-linked glycoside prodrug of taxol, i.e., 7-glycolyltaxol 2″- O -α-D-glucopyranoside, was investigated by chemical synthetic procedure.
Hiroki Hamada, Shouta Okada, Noriyoshi Masuoka, Hatsuyuki Hamada, Kei Shimoda, Katsuhiko Mikuni, Yuya Fujitaka   +6 more
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Profiles and Bioinformatics Analysis of Differentially Expressed Circrnas in Taxol-Resistant Non-Small Cell Lung Cancer Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Circular RNAs (circRNAs) act as microRNA (miRNA) sponges that regulate gene expression and are involved in physiological and pathological processes.
Ning Xu, Shaomu Chen, Yufeng Liu, Wei Li, Zeyi Liu, Xiaojie Bian, Chunhua Ling, Min Jiang   +7 more
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Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora.

PLoS ONE, 2019
Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L-1, 45- fold higher than that of the control.
Kamalraj Subban, Ramesh Subramani, Vishnu Priya Madambakkam Srinivasan, Muthumary Johnpaul, Jayabaskaran Chelliah   +4 more
doaj   +1 more source

Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production

Nature Communications, 2017
Taxol is a widely used anticancer drug that is found in very low amounts in the bark of Taxus plants. Here, the authors improve the catalytic fitness of DBAT, an enzyme that catalyses the conversion of tree by products into taxol, enabling the design of ...
Bing-Juan Li, Hao Wang, Ting Gong, Jing-Jing Chen, Tian-Jiao Chen, Jin-Ling Yang, Ping Zhu   +6 more
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The Cytotoxic Effects of Silymarin on the 4T1 Cell Line Derived from BALB/c Mice Mammary Tumors

Journal of Medicinal Plants, 2014
Background: There is an increasing interest in identifying potent cancer preventive and therapeutic agents. Silymarin is a flavonoids complex extracted from the milk thistle (Silybum marianum L.) seeds.
SMA Shariatzadeh, A Hamta, M Soleimani, H Fallah Huseini, S Samavat   +4 more
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Human mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism

Cell Communication and Signaling
Background The release of extracellular vesicles (EVs) including exosomes from human mesenchymal stroma/stem-like cells (MSC) represents valuable cell-free carriers for the delivery of regenerative and medicinal compounds.
Ralf Hass, Juliane von der Ohe, Tianjiao Luo   +2 more
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Hazel (Corylus avellana L.) as a New Source of Taxol and Taxanes

Journal of Medicinal Plants, 2012
Taxol is used to treatment of variety cancers including ovarian, breast, lung, head and neck carcinomas and the AIDS-related Karposi’s carcinoma, and was originally obtained from bark of taxus brevifolia.
A Qaderi, M Omidi, A Etminan, A Oladzad, C Ebrahimi, MR Dehghani Mashkani, A Mehrafarin   +6 more
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Over - expression Effect of Gene Encoding 3-hydroxy-3-Methylglutaryl-CoA Reductase on Production of Taxol in Iranian Hazel (Corylus avellana L.)

Journal of Medicinal Plants, 2013
Background: Sustainable and commercial production of taxol as an anti cancer drug is a critical point to its clinical application. Nowadays, hazel because of rapid growth and wide range distribution is considered as an alternative source of Taxol ...
A Qaderi, M Omidi, AR Zebarjadi, R Hajiaghaee   +3 more
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