Results 1 to 10 of about 31,972 (221)

Apoptosis and Taxol Therapy [PDF]

Cancer Biology & Therapy, 2002
No Abstract AvailableCommentary to:Title: Paclitaxel-Induced FasL-Independent Apoptosis and Slow (Non-Apoptotic) Cell Death Authors: Mikhail V. Blagosklonny, Robert Robey, M.
David J, McConley, Darren W, Davis
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An investigation of the role of the ErbB receptor family in chemotherapeutic drug resistance and invasion in human breast cancer [PDF]

, 2002
The purpose of the work described in this thesis was to investigate the effects of upregulation of c-erbB-2 by cDNA transfection and the downregulation by ribozyme transfection on chemotherapeutic drug sensitivity, in vitro invasion, and expression of a ...
Glynn, Sharon
core  

Taxol synthesis

, 2016
Being a complex diterpenoid, the potent anticancer drug, Taxol, requires complicated steps for its biosynthesis. In the present article, recent advances on Taxol biosynthesis pathway are reviewed, including many recently reported genes that regulate ...
Jin, HB, Tang, KX, Guo, BH, Kai, GY
core   +1 more source

Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition

Cancer Cell International, 2019
Background Breast cancer, the most common invasive cancer of women, is a malignant neoplasm and the second main cause of cancer death. Resistance to paclitaxel (Taxol), one of the frequently used chemotherapy agents for breast cancer, presents a major ...
Lu Hou, Yi Zhao, Guo-qing Song, Ying-han Ma, Xiao-hu Jin, Si-li Jin, Yi-han Fang, Yi-chong Chen   +7 more
doaj   +1 more source

Salicylic Acid-Responsive Factor TcWRKY33 Positively Regulates Taxol Biosynthesis in Taxus chinensis in Direct and Indirect Ways

Frontiers in Plant Science, 2021
Taxol is a rare secondary metabolite that accumulates considerably in Taxus species under salicylic acid (SA) and methyl jasmonate treatment. However, the molecular mechanism of its accumulation remains unclear.
Ying Chen, Ying Chen, Ying Chen, Hua Zhang, Hua Zhang, Hua Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Wenli Zhang, Wenli Zhang, Wenli Zhang, Ziqi Ou, Ziqi Ou, Ziqi Ou, Zehang Peng, Zehang Peng, Zehang Peng, Chunhua Fu, Chunhua Fu, Chunhua Fu, Chunfang Zhao, Chunfang Zhao, Chunfang Zhao, Longjiang Yu, Longjiang Yu, Longjiang Yu   +26 more
doaj   +1 more source

Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest.

PLoS ONE, 2011
BackgroundTaxol is a microtubule stabilizing agent that arrests cells in mitosis leading to cell death. Taxol is widely used to treat breast cancer, but resistance occurs in 25-69% of patients and it is vital to understand how Taxol resistance develops ...
Nasser Samadi, Raie T Bekele, Ing Swie Goping, Luis M Schang, David N Brindley   +4 more
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High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer

Journal of Ovarian Research, 2022
Background Taxol resistance in serous ovarian cancer is responsible for its poor prognosis, yet the underlying mechanism is still poorly understood. Thus, we probed the mechanism of Taxol resistance in serous ovarian cancer with multiple bioinformatic ...
Yuqing Shen, Hui Lin, Kelie Chen, Wanzhong Ge, Dajing Xia, Yihua Wu, Weiguo Lu   +6 more
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The mass spectrometry of taxol [PDF]

Journal of the American Society for Mass Spectrometry, 1992
The antitumor agent taxol has been examined by electron ionization, chemical ionization, and fast atom bombardment mass spectrometry. Three ion series are observed: (1) the M-series, characteristic of the intact molecule; (2) the T-series, with fragments derived from the taxane ring; and (3) the S-series representing the C-13 side chain. Neutral losses
McClure, Thomas D., Schram, Karl H., Reimer, Mark L.J.   +2 more
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Allicin: A natural weapon against Taxol resistance in non‐small cell lung cancer through Cathepsin B inhibition and lysosomal‐autophagy disruption

Food Frontiers
Drug resistance in non‐small cell lung cancer (NSCLC) limits its therapeutic efficacy. Allicin may help to solve the problem of Taxol resistance in NSCLC.
Xudong Gao, Chang Xu, Ramesh Kumar Santhanam, Yingshi Zhang, Qingchun Zhao   +4 more
doaj   +1 more source

Taxol Biosynthesis: An Update [PDF]

Planta Medica, 1997
The novel diterpenoid taxol (paclitaxel) is now well-established as a potent chemotherapeutic agent. Total synthesis of the drug is not commercially feasible and, in the foreseeable future, the supply of taxol and its synthetically useful progenitors must rely on biological methods of production.
M, Hezari, R, Croteau
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