Results 1 to 10 of about 34,289 (210)

Production and Characterization of Taxol as Anticancer Agent from Aspergillus terreus

Journal of Pure and Applied Microbiology, 2019
Taxol, a diterpenoid was initially isolated from the bark of Taxus brevifolia, approved by FDA in 1994 as a powerful drug for metastatic ovarian carcinoma, breast and lung cancer.
Ashraf S.A. El-Sayed, Manal T. El Sayed, Hend S. Nada, Abdallah E. Hassan, Eman K. Yousef   +4 more
doaj   +2 more sources

Iso-Seq analysis of the Taxus cuspidata transcriptome reveals the complexity of Taxol biosynthesis

BMC Plant Biology, 2019
Background Taxus cuspidata is well known worldwide for its ability to produce Taxol, one of the top-selling natural anticancer drugs. However, current Taxol production cannot match the increasing needs of the market, and novel strategies should be ...
Xuejun Kuang, Sijie Sun, Jianhe Wei, Ying Li, Chao Sun   +4 more
doaj   +1 more source

Taxol production by Fusarium arthrosporioides isolated from yew, Taxus cuspidata [PDF]

Journal of Medical Biochemistry, 2008
A taxol-producing endophyte was Fusarium arthrosporioides. As a novel taxol resource, a taxol-producing endophyte was successfully isolated from the yew tree, Taxus cuspidata Sieb. et Zucc.
Chang-Tian Li, Yu Li, Wang Qi-Jun, Sung Chang-Keun   +3 more
doaj  

The role of gold nanoparticles on taxol-induced renal cortex damage in adult male albino rats [PDF]

The Egyptian Journal of Histology, 2018
Introduction: Taxol is a chemotherapeutic drug widely used in the treatment of various types of cancer. Nephrotoxicity is themost hazardous effect complicating chemotherapy.Aim of the work: This research aimed to evaluate the effect of gold nanoparticles
Abeer Mahmoud, Maha Mohammed, Samah Ahmed   +2 more
doaj   +1 more source

Endophytic fungus Pseudodidymocyrtis lobariellae KL27 promotes taxol biosynthesis and accumulation in Taxus chinensis

BMC Plant Biology, 2022
Background Taxol from Taxus species is a precious drug used for the treatment of cancer and can effectively inhibit the proliferation of cancer cells. However, the growth of Taxus plants is very slow and the content of taxol is quite low.
Xiaoying Cao, Lingxia Xu, Jingyi Wang, Mengmeng Dong, Chunyan Xu, Guoyin Kai, Wen Wan, Jihong Jiang   +7 more
doaj   +1 more source

Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury

Mediators of Inflammation, 2023
Axonal regeneration has been the research focus in the field of clinical treatment for spinal cord injury (SCI). The growth and extension of neuronal axons is a dynamic biological process mediated by the cytoskeleton, and microtubule plays an important ...
Baoguo Liu, Sumei Liu, Dejun Sun
doaj   +1 more source

Production and bioprocessing of Taxol from Aspergillus niger, an endophyte of Encephalartos whitelockii, with a plausible biosynthetic stability: antiproliferative activity and cell cycle analysis

Microbial Cell Factories
The biosynthetic potency of Taxol by fungi raises their prospective to be a platform for commercial production of Taxol, nevertheless, the attenuation of its productivity with the fungal storage, is the challenge.
Asmaa Gamal, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Ashraf S. A. El-Sayed, Maher M. El-Domiaty   +5 more
doaj   +1 more source

Taxol crystals can masquerade as stabilized microtubules. [PDF]

PLoS ONE, 2008
Taxol is a potent anti-mitotic drug used in chemotherapy, angioplastic stents, and cell biology research. By binding and stabilizing microtubules, Taxol inhibits their dynamics, crucial for cell division, motility, and survival.
Margit Foss, Buck W L Wilcox, G Bradley Alsop, Dahong Zhang   +3 more
doaj   +1 more source

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation

Scientific Reports, 2017
Taxol, a first-line anti-tumour drug, has low effectiveness against colorectal cancer. Combination with other agents is an effective strategy to enhance Taxol cytotoxicity.
Yijia Wang, Chunze Zhang, Shiwu Zhang, Zhenying Zhao, Jiawen Wang, Jiali Song, Yue Wang, Jun Liu, Shaobin Hou   +8 more
doaj   +1 more source

Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition

Cancer Cell International, 2019
Background Breast cancer, the most common invasive cancer of women, is a malignant neoplasm and the second main cause of cancer death. Resistance to paclitaxel (Taxol), one of the frequently used chemotherapy agents for breast cancer, presents a major ...
Lu Hou, Yi Zhao, Guo-qing Song, Ying-han Ma, Xiao-hu Jin, Si-li Jin, Yi-han Fang, Yi-chong Chen   +7 more
doaj   +1 more source