Results 1 to 10 of about 31,992 (181)

Taxol acts differently on different tubulin isotypes [PDF]

Communications Biology, 2023
Taxol is a small molecule effector that allosterically locks tubulin into the microtubule lattice. We show here that taxol has different effects on different single-isotype microtubule lattices.
Yean Ming Chew, Robert A. Cross
doaj   +2 more sources

Conjugation of Aspergillus flavipes Taxol with Porphyrin Increases the Anticancer Activity of Taxol and Ameliorates Its Cytotoxic Effects [PDF]

Molecules, 2020
Taxol is one of the potential anticancer drugs; however, the yield of Taxol and its cytotoxicity are common challenges. Thus, manipulating the Taxol biosynthetic pathway from endophytic fungi, in addition to chemical modification with biocompatible ...
Ashraf S. A. El-Sayed, Maher Fathalla, Marwa A. Yassin, Nabila Zein, Shaima Morsy, Mahmoud Sitohy, Basel Sitohy   +6 more
doaj   +2 more sources

Production, bioprocess optimization and γ-irradiation of Penicillium polonicum, as a new Taxol producing endophyte from Ginko biloba

Biotechnology Reports (Amsterdam, Netherlands), 2021
Twenty-eight fungal endophytes were recovered from the different parts of Ginkgo biloba and screened for their Taxol producing potency. Among these isolates, Penicillium polonicum AUMC14487 was reported as the potent Taxol producer (90.53 μg/l).
Ahmed El-Batal, Ashraf El-Sayed, Gamal El-Sherbiny   +2 more
exaly   +3 more sources

Darkness: A Crucial Factor in Fungal Taxol Production [PDF]

Frontiers in Microbiology, 2018
Fungal Taxol acquired lots of attention in the last few decades mainly because of the hope that fungi could be manipulated more easily than yew trees to scale up the production level of this valuable anticancer drug.
Sameh S. M. Soliman, Sameh S. M. Soliman, Sameh S. M. Soliman, Manish N. Raizada   +3 more
doaj   +2 more sources

Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities [PDF]

Microbial Cell Factories
Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production.
Asmaa Gamal, Ashraf S. A. El-Sayed, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Maher M. El-Domiaty   +5 more
doaj   +2 more sources

Transcriptome-based signature predicts the effect of taxol in serous ovarian cancer. [PDF]

PLoS ONE, 2018
Taxol is a widely used chemotherapy drug used clinically for ovarian cancer, although the response to Taxol among individuals varies due to the heterogeneity among ovarian cancer patients. In this work, we analyzed differences in the prognostic effect of
Shunyu Hou, Jianrong Dai
doaj   +1 more source

Detection, Purification and Elucidation of Chemical Structure and Antiproliferative Activity of Taxol Produced by Penicillium chrysogenum

Molecules, 2020
Penicillium chrysogenum has been reported as a potent taxol producer based on quantitative analysis by TLC and HPLC. The biosynthetic potency of taxol has been validated from PCR detection of rate-limiting genes of taxol synthesis such as ...
Ashraf El-Sayed, Gamal Enan, Abdul-Raouf Al-Mohammadi, Ahmed H. Moustafa, Nashwa El-Gazzar   +4 more
doaj   +1 more source

An endophytic Basidiomycete, Grammothele lineata, isolated from Corchorus olitorius, produces paclitaxel that shows cytotoxicity. [PDF]

PLoS ONE, 2017
Grammothele lineata, an endophyte isolated in our laboratory from jute (Corchorus olitorius acc. 2015) was found to be a substantial paclitaxel producer.
Avizit Das, Mohammad Imtiazur Rahman, Ahlan Sabah Ferdous, Al- Amin, Mohammad Mahbubur Rahman, Nilufar Nahar, Md Aftab Uddin, Mohammad Riazul Islam, Haseena Khan   +8 more
doaj   +1 more source

Local Delivery of Taxol From FGL-Functionalized Self-Assembling Peptide Nanofiber Scaffold Promotes Recovery After Spinal Cord Injury

Frontiers in Cell and Developmental Biology, 2020
Taxol has been clinically approved as an antitumor drug, and it exerts its antitumor effect through the excessive stabilization of microtubules in cancer cells.
Zhiyong Xiao, Yingtao Yao, Yingtao Yao, Zhiyu Wang, Qing Tian, Jiedong Wang, Li Gu, Bo Li, Qixin Zheng, Yongchao Wu   +9 more
doaj   +1 more source

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

Molecular Cancer, 2010
Background Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol.
Riker Adam I, Fodstad Oystein, Liu Zixing, Liu Hao, Ding Yan, Zhao Yuhua, Zhou Ming, Kamarajugadda Sushama, Lu Jianrong, Owen Laurie B, Ledoux Susan P, Tan Ming   +11 more
doaj   +1 more source