Results 41 to 50 of about 34,289 (210)

Enantioselective Total Synthesis of (−)-Taxol

, 2016
Enantioselective total synthesis of taxol has been accomplished. Coupling reaction of the optically pure A-ring hydroxy aldehyde with the aromatic C-ring fragment followed by Lewis acid mediated eight-membered B-ring cyclization gave the desired ABC endo-
Nobuhito Nakamura (3005613), Hiroyuki Kusama (1925068), Toshiyuki Nishimori (3005604), Ryoma Hara (2997180), Koichiro Morihira (3005610), Isao Kuwajima (2496277), Shigeru Kawahara (3005607), Hajime Kashima (2827205)   +7 more
core   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

How taxol modulates microtubule disassembly. [PDF]

, 1994
Measurement of the affinity of microtubules for the anti-cancer drug taxol is problematic, because microtubules are not stable at the very low concentrations required to detect taxol dissociation.

core   +1 more source

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

Allicin: A natural weapon against Taxol resistance in non‐small cell lung cancer through Cathepsin B inhibition and lysosomal‐autophagy disruption

Food Frontiers
Drug resistance in non‐small cell lung cancer (NSCLC) limits its therapeutic efficacy. Allicin may help to solve the problem of Taxol resistance in NSCLC.
Xudong Gao, Chang Xu, Ramesh Kumar Santhanam, Yingshi Zhang, Qingchun Zhao   +4 more
doaj   +1 more source

Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest.

PLoS ONE, 2011
BackgroundTaxol is a microtubule stabilizing agent that arrests cells in mitosis leading to cell death. Taxol is widely used to treat breast cancer, but resistance occurs in 25-69% of patients and it is vital to understand how Taxol resistance develops ...
Nasser Samadi, Raie T Bekele, Ing Swie Goping, Luis M Schang, David N Brindley   +4 more
doaj   +1 more source

High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer

Journal of Ovarian Research, 2022
Background Taxol resistance in serous ovarian cancer is responsible for its poor prognosis, yet the underlying mechanism is still poorly understood. Thus, we probed the mechanism of Taxol resistance in serous ovarian cancer with multiple bioinformatic ...
Yuqing Shen, Hui Lin, Kelie Chen, Wanzhong Ge, Dajing Xia, Yihua Wu, Weiguo Lu   +6 more
doaj   +1 more source

Salicylic Acid-Responsive Factor TcWRKY33 Positively Regulates Taxol Biosynthesis in Taxus chinensis in Direct and Indirect Ways

Frontiers in Plant Science, 2021
Taxol is a rare secondary metabolite that accumulates considerably in Taxus species under salicylic acid (SA) and methyl jasmonate treatment. However, the molecular mechanism of its accumulation remains unclear.
Ying Chen, Ying Chen, Ying Chen, Hua Zhang, Hua Zhang, Hua Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Wenli Zhang, Wenli Zhang, Wenli Zhang, Ziqi Ou, Ziqi Ou, Ziqi Ou, Zehang Peng, Zehang Peng, Zehang Peng, Chunhua Fu, Chunhua Fu, Chunhua Fu, Chunfang Zhao, Chunfang Zhao, Chunfang Zhao, Longjiang Yu, Longjiang Yu, Longjiang Yu   +26 more
doaj   +1 more source

The mass spectrometry of taxol [PDF]

Journal of the American Society for Mass Spectrometry, 1992
The antitumor agent taxol has been examined by electron ionization, chemical ionization, and fast atom bombardment mass spectrometry. Three ion series are observed: (1) the M-series, characteristic of the intact molecule; (2) the T-series, with fragments derived from the taxane ring; and (3) the S-series representing the C-13 side chain. Neutral losses
McClure, Thomas D., Schram, Karl H., Reimer, Mark L.J.   +2 more
openaire   +2 more sources

Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays

Cytoskeleton, EarlyView.
ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz, Benjamin Powers, Jayne Aiken   +2 more
wiley   +1 more source