Results 41 to 50 of about 31,992 (181)
Cytoskeleton, EarlyView.ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas +5 more
wiley +1 more source
Microbial Cell FactoriesThe biosynthetic potency of Taxol by fungi raises their prospective to be a platform for commercial production of Taxol, nevertheless, the attenuation of its productivity with the fungal storage, is the challenge.
Asmaa Gamal +5 more
doaj +1 more source
Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1
Cytoskeleton, EarlyView.ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley +1 more source
Taxol Reduces Cytosolic E-Cadherin and Beta-Catenin Levels in Nasopharyngeal Carcinoma Cell Line Tw-039: Cross-Talk between the Microtubule- and Actin-Based Cytoskeletons [PDF]
, 2008 Taxol affects microtubule dynamics by promoting microtubule assembly. To obtain a better insight into possible cross- talk between the microtubule- and actin-based cytoskeletons, we studied the short-term effects of Taxol treatment on the expression of ...
LOU, PEI-JEN;CHEN, WEN-PIN;LIN, CHIN- TARNG;CHEN, HUI-CHIN;WU, JIAHN-CHUN +1 more
core
Taxol crystals can masquerade as stabilized microtubules. [PDF]
PLoS ONE, 2008 Taxol is a potent anti-mitotic drug used in chemotherapy, angioplastic stents, and cell biology research. By binding and stabilizing microtubules, Taxol inhibits their dynamics, crucial for cell division, motility, and survival.
Margit Foss +3 more
doaj +1 more source
Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays
Cytoskeleton, EarlyView.ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz +2 more
wiley +1 more source
An investigation of the role of the ErbB receptor family in chemotherapeutic drug resistance and invasion in human breast cancer [PDF]
, 2002 The purpose of the work described in this thesis was to investigate the effects of upregulation of c-erbB-2 by cDNA transfection and the downregulation by ribozyme transfection on chemotherapeutic drug sensitivity, in vitro invasion, and expression of a ...
Glynn, Sharon
core
Performance of Taxol score in validation datasets. [PDF]
, 2018 The performance of Taxol score was validated in the high Taxol score group (A) and low Taxol score group (B) in the GSE63885 cohort and GSE9891 cohort (C-D, high and low Taxol score group).
Jianrong Dai (517364) +1 more
core +1 more source
Scientific Reports, 2017 Taxol, a first-line anti-tumour drug, has low effectiveness against colorectal cancer. Combination with other agents is an effective strategy to enhance Taxol cytotoxicity.
Yijia Wang +8 more
doaj +1 more source
Cancer Cell International, 2019 Background Breast cancer, the most common invasive cancer of women, is a malignant neoplasm and the second main cause of cancer death. Resistance to paclitaxel (Taxol), one of the frequently used chemotherapy agents for breast cancer, presents a major ...
Lu Hou +7 more
doaj +1 more source