Results 21 to 30 of about 34,289 (210)
Frontiers in Cell and Developmental Biology, 2020 Taxol has been clinically approved as an antitumor drug, and it exerts its antitumor effect through the excessive stabilization of microtubules in cancer cells.
Zhiyong Xiao +9 more
doaj +1 more source
Molecular Cancer, 2010 Background Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol.
Riker Adam I +11 more
doaj +1 more source
Darkness: A Crucial Factor in Fungal Taxol Production
Frontiers in Microbiology, 2018 Fungal Taxol acquired lots of attention in the last few decades mainly because of the hope that fungi could be manipulated more easily than yew trees to scale up the production level of this valuable anticancer drug.
Sameh S. M. Soliman +3 more
doaj +1 more source
Frontiers in Plant Science, 2022 Taxol is a precious and effective anticancer drug. Cerium and methyl jasmonate (MJ) have been shown to increase the yield of taxol in taxus cells. However, the mechanisms of cerium-mediated and MJ-mediated taxol biosynthesis remain unknown.
Na Han +9 more
doaj +1 more source
Mdivi-1 induces spindle abnormalities and augments taxol cytotoxicity in MDA-MB-231 cells
Cell Death Discovery, 2021 Taxol is a first-line chemotherapeutic for numerous cancers, including the highly refractory triple-negative breast cancer (TNBC). However, it is often associated with toxic side effects and chemoresistance in breast cancer patients, which greatly limits
Chieh-Ting Fang +4 more
doaj +1 more source
Baseline survey of root-associated microbes of Taxus chinensis (Pilger) Rehd. [PDF]
PLoS ONE, 2015 Taxol (paclitaxel) a diterpenoid is one of the most effective anticancer drugs identified. Biosynthesis of taxol was considered restricted to the Taxus genera until Stierle et al.
Qian Zhang +7 more
doaj +1 more source
Molecules, 2021 Taxol is one of the most effective anticancer drugs in the world that is widely used in the treatments of breast, lung and ovarian cancer. The elucidation of the taxol biosynthetic pathway is the key to solve the problem of taxol supply.
Tao Wang +6 more
doaj +1 more source
Blood-based proteomic profiling reveals context-dependent changes in BCL2-associated signaling during taxane therapy in breast cancer patients. [PDF]
FEBS Open BioChemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Munshani S +6 more
europepmc +2 more sources
Biotechnology Reports, 2019 Taxol® (generic name Paclitaxel) is a chemotherapeutic drug, effective against head, neck, breast, lung, bladder, ovary, and cervix cancers. Rising demands in chemotherapy and limited supply of natural taxol have ultimately increased the cost of the drug.
Pradeep Kumar +6 more
doaj +1 more source
Development of taxane resistance in a panel of human lung cancer cell lines [PDF]
, 2008 Using a selection process designed to reflect clinically relevant conditions, a panel of taxane-selected variants were developed to study further the mechanisms of resistance in lung cancer.
Keenan, Joanne +3 more
core +2 more sources