Pacific Blue Derivatives of Paclitaxel as Fluorescent Probes of OATP1B‐Type Transporters [PDF]
Clinical and Translational SciencePaclitaxel (Taxol) is a widely used anticancer agent that undergoes extensive hepatic metabolism and that causes a debilitating, dose‐limiting peripheral neurotoxicity.
Mahesh R. Nepal +11 more
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Analysis of MS/MS Fragmentation of Taxoids [PDF]
Natural Product Communications, 2010 The fragmentation pathways of seven types of taxoids were investigated by using a LC-MS/MS method, namely: (1) neutral taxoids with a C-4(20) double bond; (2) taxoids with a C-4(20) double bond and oxygenation at C-14; (3) 5-cinnamoyl taxoids with a C-4 ...
Ken Tanaka, Suresh Awale
exaly +4 more sources
Effect of Methyl Jasmonate on the Growth and Biosynthesis of C13- and C14-Hydroxylated Taxoids in the Cell Culture of Yew (Taxus wallichiana Zucc.) of Different Ages [PDF]
Biomolecules, 2023 The effects of methyl jasmonate (MeJ) on growth and taxoid formation in the cell culture of Taxus wallichiana were investigated to elucidate the specifics of phytohormone action in dedifferentiated plant cells in vitro.
Elena Demidova +4 more
doaj +2 more sources
Profiling of Taxoid Compounds in Plant Cell Cultures of Different Species of Yew (Taxus spp.) [PDF]
Molecules, 2023 Plant cell cultures of various yew species are a profitable source of taxoids (taxane diterpenoids) with antitumor activity. So far, despite intensive studies, the principles of the formation of different groups of taxoids in cultured in vitro plant ...
Dmitry V. Kochkin +3 more
doaj +2 more sources
Paclitaxel biological synthesis promotes the innovation of anti-cancer drugs. [PDF]
Clin Transl MedClinical and Translational Medicine, Volume 15, Issue 2, February 2025.
Zhang X, Liu G, Yan J.
europepmc +2 more sources
Quality evaluation of compounds in leaves of six Taxus species based on UPLC-MS/MS and chemometrics [PDF]
Frontiers in Chemistry, 2023 Introduction:Taxus species are used as medicinal plants all over the world. The leaves of Taxus species are sustainable medicinal resources that are rich in taxoids and flavonoids.
Qingzhu Cai +13 more
doaj +2 more sources
Transcriptome and Metabolome Analyses of Taxus chinensis var. mairei Tissues Provide New Insights into the Regulation of Paclitaxel Biosynthesis [PDF]
PlantsTaxus is the natural source of the anticancer drug paclitaxel. Although significant progress has been made in elucidating the biosynthetic pathway of paclitaxel, its tissue-specific accumulation and associated regulatory networks in Taxus remains unclear.
Luyuan Jiang +9 more
doaj +2 more sources
Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol [PDF]
Nature CommunicationsTaxol is a widely-applied anticancer drug that inhibits microtubule dynamics in actively replicating cells. Although a minimum 19-step biosynthetic pathway has been proposed and 16 enzymes likely involved have been characterized, stepwise biosynthetic ...
Chengshuai Yang +9 more
doaj +2 more sources
Optimization of the fermentation media, mathematical modeling, and enhancement of paclitaxel production by Alternaria alternata after elicitation with pectin [PDF]
Scientific ReportsAlternaria alternata fungus is a potent paclitaxel producer isolated from Corylus avellana. The major challenge is the lack of optimized media for endophytic fungi productivity. In the effort to maximize the production of taxoids by A. alternata, several
Hamzeh Rezazadeh +4 more
doaj +2 more sources
Engineering of 10-Deacetylbaccatin III-10-β-O-Acetyltransferase From Taxus Species for Efficient Acetylating Non-Natural Substrates Into Taxol in Nicotiana benthamiana. [PDF]
Plant Biotechnol JABSTRACT 7‐β‐xylosyl‐10‐deacetyltaxol (XDT) is much more abundant than the anticancer drug Taxol in Taxus species and is usually regarded as the by‐product of Taxol. It could be enzymatically transformed into 10‐deacetyltaxol (DT), and the latter could be further converted into Taxol.
Chen TJ +5 more
europepmc +2 more sources