Results 21 to 30 of about 3,991 (207)
Case Reports in Urology, Volume 2023, Issue 1, 2023., 2023 Enfortumab vedotin (EV), a nectin‐4‐directed antibody conjugated to monomethyl auristatin E (MMAE), has been approved for patients with advanced urothelial carcinoma (aUC) previously treated with platinum‐based chemotherapy and immune inhibitors. Taxane agents and MMAE share antitumor mechanisms through microtubule disruption, thus raising a notable ...
Makito Miyake +12 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Diterpenes and their derivatives have many biological activities, including anti‐inflammatory and immunomodulatory effects. To date, several diterpenes, diterpenoids, and their laboratory‐derived products have been demonstrated for antiarthritic activities.
Muhammad Torequl Islam +15 more
wiley +1 more source
Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention
BioMed Research International, Volume 2022, Issue 1, 2022., 2022 Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years.
Arif Jamal Siddiqui +11 more
wiley +1 more source
Drugs in Context, 2017 Background: Eribulin mesylate is currently approved in the United States and Europe for the treatment of metastatic breast cancer (MBC). Scope: The objective of this retrospective study is to find specific predictive criteria related to patient or ...
Sabrina Rossi +6 more
doaj +1 more source
Role of Taxoids in Head and Neck Cancer [PDF]
The Oncologist, 2000 Abstract Docetaxel and paclitaxel represent a new class of cytotoxic agents having both a specific chemical structure and mechanism of action. They act to promote tubulin polymerization and the formation of stable microtubules. The microtubules produced in the presence of taxoids are resistant to disassembly by physiologic stimuli, and ...
Schrijvers, D., Vermorken, J.B.
openaire +3 more sources
Characterization of Yew Tree () Varieties by Fingerprint and Principal Component Analyses
Natural Product Communications, 2012 The composition of varieties of Taxus growing in Estonia was analyzed by capillary electrophoresis with diode array detection (CE-DAD) for the separation of phenolic compounds, and by high performance liquid chromatography-mass spectrometry (HPLC-MS) for
Kalle Truus +7 more
doaj +1 more source
Observational study of clinical toxicity with different formulations of docetaxel in breast cancer patients [PDF]
Farmacia Hospitalaria, 2020 Objective: To analyze the excipients and impurities contained in the various docetaxel products available on the market and find out whether they may be responsible for any of the different adverse events associated with the use of docetaxel in ...
Eva González-Haba-Peña +5 more
doaj +1 more source
BMC Plant Biology, 2019 Background Trees of the genus Taxus are highly valuable medicinal plants with multiple pharmacological effects on various cancer treatments. Paclitaxel from Taxus trees is an efficient and widely used anticancer drug, however, the accumulation of taxoids
Ting Zhou +10 more
doaj +1 more source
Persistent docetaxel-induced supravenous erythematous eruption [PDF]
Anais Brasileiros de Dermatologia, 2015 Taxanes are drugs used to treat many types of cancer, including breast and lung cancer. The most common side effects of these drugs are neutropenia and mucositis.
Karina de Almeida Pinto Fernandes +1 more
doaj +1 more source
Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Gaurav P. Kudalkar +15 more
wiley +2 more sources