Results 21 to 30 of about 3,403 (164)

Activities and Molecular Mechanisms of Diterpenes, Diterpenoids, and Their Derivatives in Rheumatoid Arthritis

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Diterpenes and their derivatives have many biological activities, including anti‐inflammatory and immunomodulatory effects. To date, several diterpenes, diterpenoids, and their laboratory‐derived products have been demonstrated for antiarthritic activities.
Muhammad Torequl Islam, Cristina Quispe, Jesús Herrera-Bravo, Md. Mizanur Rahaman, Rajib Hossain, Chandan Sarkar, Md Abdur Raihan, Md. Mashrur Chowdhury, Shaikh Jamal Uddin, Jamil A. Shilpi, João Marcelo de Castro e Sousa, Ana Amélia de Carvalho Melo-Cavalcante, Mohammad S. Mubarak, Javad Sharifi-Rad, Daniela Calina, Yanhong Zhu   +15 more
wiley   +1 more source

Fluorescent taxoids

Chemistry & Biology, 1996
Taxol is a natural product produced by the Pacific Yew, Taxus brevifolia, that has emerged as a prominent chemotherapeutic agent for the treatment of solid tumors. Taxol's biochemical mode of action has been well studied: it binds to microtubules, stabilizing them and preventing their depolymerization to tubulin subunits.
Guy, R.K., Scott, Z.A., Sloboda, R.D., Nicolaou, K.C.   +3 more
openaire   +2 more sources

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years.
Arif Jamal Siddiqui, Sadaf Jahan, Ritu Singh, Juhi Saxena, Syed Amir Ashraf, Andleeb Khan, Ranjay Kumar Choudhary, Santhanaraj Balakrishnan, Riadh Badraoui, Fevzi Bardakci, Mohd Adnan, Yearul Kabir   +11 more
wiley   +1 more source

Synthesis and Cytotoxicity of 7,9-O-Linked Macrocyclic C-Seco Taxoids

Molecules, 2019
A series of novel 7,9-O-linked macrocyclic taxoids together with modification at the C2 position were synthesized, and their cytotoxicities against drug-sensitive and P-glycoprotein and βIII-tubulin overexpressed drug-resistant cancer cell lines were ...
Yu Zhao, Tian-En Wang, Alberto Mills, Federico Gago, Wei-Shuo Fang   +4 more
doaj   +1 more source

Prognostic and predictive factors of eribulin efficacy in heavily pretreated patients affected by metastatic breast cancer: correlation with tumor biology and previous therapies

Drugs in Context, 2017
Background: Eribulin mesylate is currently approved in the United States and Europe for the treatment of metastatic breast cancer (MBC). Scope: The objective of this retrospective study is to find specific predictive criteria related to patient or ...
Sabrina Rossi, Alessandra Cassano, Antonia Strippoli, Giovanni Schinzari, Ettore D’Argento, Michele Basso, Carlo Barone   +6 more
doaj   +1 more source

Persistent docetaxel-induced supravenous erythematous eruption [PDF]

Anais Brasileiros de Dermatologia, 2015
Taxanes are drugs used to treat many types of cancer, including breast and lung cancer. The most common side effects of these drugs are neutropenia and mucositis.
Karina de Almeida Pinto Fernandes, Paulo Antônio Oldani Felix   +1 more
doaj   +1 more source

Observational study of clinical toxicity with different formulations of docetaxel in breast cancer patients [PDF]

Farmacia Hospitalaria, 2020
Objective: To analyze the excipients and impurities contained in the various docetaxel products available on the market and find out whether they may be responsible for any of the different adverse events associated with the use of docetaxel in ...
Eva González-Haba-Peña, Margarita Garrido-Siles, María Jose Martínez-Bautista, Amparo Burgos-San José, Azucena Aldaz-Pastor, Irene Mangues-Bafalluy   +5 more
doaj   +1 more source

Characterization of Yew Tree () Varieties by Fingerprint and Principal Component Analyses

Natural Product Communications, 2012
The composition of varieties of Taxus growing in Estonia was analyzed by capillary electrophoresis with diode array detection (CE-DAD) for the separation of phenolic compounds, and by high performance liquid chromatography-mass spectrometry (HPLC-MS) for
Kalle Truus, Merike Vaher, Maria Borissova, Marju Robal, Tuuli Levandi, Rando Tuvikene, Peeter Toomik, Mihkel Kaljurand   +7 more
doaj   +1 more source

Comparative metabolomic analysis reveals the variations in taxoids and flavonoids among three Taxus species

BMC Plant Biology, 2019
Background Trees of the genus Taxus are highly valuable medicinal plants with multiple pharmacological effects on various cancer treatments. Paclitaxel from Taxus trees is an efficient and widely used anticancer drug, however, the accumulation of taxoids
Ting Zhou, Xiujun Luo, Chengchao Zhang, Xinyun Xu, Chunna Yu, Zhifang Jiang, Lei Zhang, Huwei Yuan, Bingsong Zheng, Erxu Pi, Chenjia Shen   +10 more
doaj   +1 more source

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Gaurav P. Kudalkar, Florian Leidner, Nivesh Kumar, Jared L. Hass, Peter Madzelan, Douglas R. Powell, Victor W. Day, Pierre Le Magueres, Joseph D. Ferrara, Lee M. Daniels, Akihito Yamano, Sho Ito, Wei Niu, Helmut Grubmüller, Mark A. Wilson, David B. Berkowitz   +15 more
wiley   +2 more sources