Results 31 to 40 of about 4,048 (209)

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Gaurav P. Kudalkar, Florian Leidner, Nivesh Kumar, Jared L. Hass, Peter Madzelan, Douglas R. Powell, Victor W. Day, Pierre Le Magueres, Joseph D. Ferrara, Lee M. Daniels, Akihito Yamano, Sho Ito, Wei Niu, Helmut Grubmüller, Mark A. Wilson, David B. Berkowitz   +15 more
wiley   +2 more sources

Design, Synthesis, and Biological Evaluation of Novel C14−C3′BzN-Linked Macrocyclic Taxoids

, 2016
Novel macrocyclic paclitaxel congeners were designed to mimic the bioactive conformation of paclitaxel. Computational analysis of the “REDOR-Taxol” structure revealed that this structure could be rigidified by connecting the C14 position of the baccatin ...
Ralph J. Bernacki (2402203), Carlos Simmerling (1304823), Yuan Li (67017), Joseph W. Lauher (2128129), Jean M. Veith (2402200), Iwao Ojima (295240), Susan B. Horwitz (2402209), Xudong Geng (2402215), Paula Pera (2146381), Liang Sun (92795), Shujun Xia (2402206), Zhong Li (324520), Raphaël Geney (2402212)   +12 more
core   +2 more sources

Taxane Diterpene Synthesis Studies. Part 1: Chemoenzymatic and Enantiodivergent Routes to AB-ring Substructures of Taxoids and ent -Taxoids

, 2015
The microbially derived cis-1,2-dihydrocatechol 2 has been converted, via reaction sequences including Diels-Alder cycloaddition and anionic oxy-Cope rearrangement steps, into enantiopure bicyclo[5.3.1]undecenes 21 and 34, which correspond to AB-ring ...
Banwell, Martin, Darmos, Penny, Hockless, David   +2 more
core   +1 more source

Design, Synthesis, and Biological Evaluation of New-Generation Taxoids

, 2016
Novel second-generation taxoids with systematic modifications at the C2, C10, and C3′N positions were synthesized and their structure−activity relationships studied.
Songnian Lin (2435152), David Gallager (2435155), Ilaria Zanardi (2238271), Xianrui Zhao (114382), Ralph J. Bernacki (2402203), Christopher P. Borella (2435167), Dafna Bar-Sagi (2435161), Tao Wang (12008), Jean M. Veith (2402200), Iwao Ojima (295240), Susan B. Horwitz (2402209), Jennifer L. Guerriero (353017), Jon Mallen-St. Clair (2435164), Xudong Geng (2402215), Paula Pera (2146381), Michael L. Miller (2435158), Liang Sun (92795), Larisa Kuznetsova (2298079), Chuanxing Qu (2435170), Shujun Xia (2402206), Jin Chen (130241)   +20 more
core   +1 more source

Taxoid profile in endophytic fungi isolated from Corylus avellana, introduces potential source for the production of Taxol in semi-synthetic approaches

Scientific Reports, 2022
Taxol (Paclitaxel) and its derivative taxanes are widely used in chemotherapy and treatment of different types of cancer. Although the extracted taxanes from Taxus sp. are currently used in semi-synthetic production of Taxol, providing alternative always
Narjes Mohammadi Ballakuti, Faezeh Ghanati, Hassan Zare-Maivan, Mozhgan Alipour, Mahtab Moghaddam, Parviz Abdolmaleki   +5 more
doaj   +1 more source

Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model

Frontiers in Pharmacology, 2022
Taxanes are widely used in the treatment of ovarian carcinomas. One of the main problems with conventional taxanes is the risk of development of multidrug resistance.
Karolina Seborova, Karolina Seborova, Kamila Koucka, Kamila Koucka, Alzbeta Spalenkova, Alzbeta Spalenkova, Alzbeta Spalenkova, Petr Holy, Petr Holy, Petr Holy, Marie Ehrlichova, Marie Ehrlichova, Tomas Sychra, Tomas Sychra, Lei Chen, Hersh Bendale, Iwao Ojima, Cristian Sandoval-Acuña, Jaroslav Truksa, Pavel Soucek, Pavel Soucek, Radka Vaclavikova, Radka Vaclavikova   +22 more
doaj   +1 more source

Synthesis of Novel C2−C3‘N-Linked Macrocyclic Taxoids by Means of Highly Regioselective Heck Macrocyclization

, 2016
Novel C2−C3‘N-linked macrocyclic taxoids are synthesized using intramolecular Heck reaction in the key step. Macrocyclization proceeds with high regioselectivity in good yield.
Songnian Lin (2435152), Xudong Geng (2402215), Michael L. Miller (2435158), Iwao Ojima (295240)   +3 more
core   +1 more source

Seasonal Dynamics of Metabolites in Needles of Taxus wallichiana var. mairei

Molecules, 2016
Seasonal variations of the phytochemicals contents in needles of T. wallichiana var. mairei due to the effects of growth meteorological parameters were investigated in this study. The needles of T. wallichiana var.
Li Yang, Zan-Sheng Zheng, Fang Cheng, Xiao Ruan, De-An Jiang, Cun-De Pan, Qiang Wang   +6 more
doaj   +1 more source

MOESM7 of Comparative metabolomic analysis reveals the variations in taxoids and flavonoids among three Taxus species

, 2019
Additional file 7: Figure S5.
Chenjia Shen (630236), Huwei Yuan (2839091), Lei Zhang (38117), Chunna Yu (722020), Ting Zhou (38572), Xiujun Luo (5398052), Zhifang Jiang (4904431), Erxu Pi (497364), Xinyun Xu (6661547), Chengchao Zhang (6248711), Bingsong Zheng (2608033)   +10 more
core   +1 more source

Engineering of 10‐Deacetylbaccatin III‐10‐β‐O‐Acetyltransferase From Taxus Species for Efficient Acetylating Non‐Natural Substrates Into Taxol in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3308-3323, May 2026.
ABSTRACT 7‐β‐xylosyl‐10‐deacetyltaxol (XDT) is much more abundant than the anticancer drug Taxol in Taxus species and is usually regarded as the by‐product of Taxol. It could be enzymatically transformed into 10‐deacetyltaxol (DT), and the latter could be further converted into Taxol.
Tian‐Jiao Chen, Jing‐Jing Chen, Xiao‐Yan Sun, Ting Gong, Jin‐Ling Yang, Ping Zhu   +5 more
wiley   +1 more source