Results 31 to 40 of about 3,403 (164)

Seasonal Dynamics of Metabolites in Needles of Taxus wallichiana var. mairei

Molecules, 2016
Seasonal variations of the phytochemicals contents in needles of T. wallichiana var. mairei due to the effects of growth meteorological parameters were investigated in this study. The needles of T. wallichiana var.
Li Yang, Zan-Sheng Zheng, Fang Cheng, Xiao Ruan, De-An Jiang, Cun-De Pan, Qiang Wang   +6 more
doaj   +1 more source

Taxoid profile in endophytic fungi isolated from Corylus avellana, introduces potential source for the production of Taxol in semi-synthetic approaches

Scientific Reports, 2022
Taxol (Paclitaxel) and its derivative taxanes are widely used in chemotherapy and treatment of different types of cancer. Although the extracted taxanes from Taxus sp. are currently used in semi-synthetic production of Taxol, providing alternative always
Narjes Mohammadi Ballakuti, Faezeh Ghanati, Hassan Zare-Maivan, Mozhgan Alipour, Mahtab Moghaddam, Parviz Abdolmaleki   +5 more
doaj   +1 more source

Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model

Frontiers in Pharmacology, 2022
Taxanes are widely used in the treatment of ovarian carcinomas. One of the main problems with conventional taxanes is the risk of development of multidrug resistance.
Karolina Seborova, Karolina Seborova, Kamila Koucka, Kamila Koucka, Alzbeta Spalenkova, Alzbeta Spalenkova, Alzbeta Spalenkova, Petr Holy, Petr Holy, Petr Holy, Marie Ehrlichova, Marie Ehrlichova, Tomas Sychra, Tomas Sychra, Lei Chen, Hersh Bendale, Iwao Ojima, Cristian Sandoval-Acuña, Jaroslav Truksa, Pavel Soucek, Pavel Soucek, Radka Vaclavikova, Radka Vaclavikova   +22 more
doaj   +1 more source

Docetaxel-induced Scleroderma in A Breast Cancer Patient: A Case Report

European Journal of Breast Health, 2015
Paclitaxel and docetaxel are antineoplastic drugs derived from the yew tree, Taxus brevifolia. They are the members of the taxane family and act by inhibiting mitotic activity due to the suppression of microtubule depolymerization.
Murat Özgür Kılıç, Metin Yalaza, Celal İsmail Bilgiç, Cenap Dener   +3 more
doaj   +1 more source

An Unusual Case Presentation on Docetaxel Induced Lung Injury

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Docetaxel can rarely cause acute interstitial lung injury early in therapy. New‐onset cough, fever, or dyspnea after chemotherapy should prompt immediate evaluation, exclusion of infection, and high‐resolution CT imaging. Early drug withdrawal and timely corticosteroid therapy can result in rapid clinical recovery and prevent serious morbidity.
Soorej Balan Kaliyath, S. Pavani, Arup Kumar Misra, A. Kesav Ramgopal, S. Yugandhar, Sushil Sharma, L. V. Simhachalam Kutikuppala, Golla Varshitha   +7 more
wiley   +1 more source

Transcriptome analyses provide insights into the expression pattern and sequence similarity of several taxol biosynthesis-related genes in three Taxus species

BMC Plant Biology, 2019
Background Taxol is an efficient anticancer drug; however, the accumulation of taxoids can vary hugely among Taxus species. The mechanism underlying differential accumulation of taxoids is largely unknown. Thus, comparative analysis of the transcriptomes
Ting Zhou, Xiujun Luo, Chunna Yu, Chengchao Zhang, Lei Zhang, Yao-bin Song, Ming Dong, Chenjia Shen   +7 more
doaj   +1 more source

Orthoquinone, Cyclic, and Acyclic α‐Diketone Natural Products: From Food Applications to Pharmacotherapy

Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.
The orthoquinone metabolites from plants have antimicrobial, antioxidant, antiviral, cytotoxic, and anti‐inflammatory effects. ABSTRACT The structural diversity of natural products is vast and fascinating, and they have been recognized as an enormously diverse source of new lead compounds.
Hidayat Hussain, Daijie Wang, Satyajit D. Sarker, Lutfun Nahar, Nilufar Z. Mamadalieva, Jianbo Xiao   +5 more
wiley   +1 more source

Patient factors associated with discrepancies between patient-reported and clinician-documented peripheral neuropathy in women with breast cancer receiving paclitaxel: A pilot study

Breast, 2020
Purpose: Discrepancies between clinicians’ assessment of chemotherapy-induced peripheral neuropathy (CIPN) and patient-reported outcomes (PRO) have been described, though the underlying reasons are unknown. Our objective was to identify potential patient-
Teresa M. Salgado, Jin Liu, Holly L. Reed, Caroline S. Quinn, Jillian G. Syverson, Jennifer Le-Rademacher, Camden L. Lopez, Andreas S. Beutler, Charles L. Loprinzi, Kiran Vangipuram, Ellen M. Lavoie Smith, N Lynn Henry, Karen B. Farris, Daniel L. Hertz   +13 more
doaj   +1 more source

Synthesis of Taxane ABC Tricyclic Skeleton from Lycoctonine

Natural Product Communications, 2012
A new conversional synthesis of the ABC ring system of taxoids from the C 19 -diterpenoid alkaloid lycoctonine was developed in 6 steps with 2% overall yield. The distinctive features of the conversion include pinacol rearrangement, enlargement of ring B,
Xiao-Xia Liang, Pei Tang, Qiao-Hong Chen, Feng-Peng Wang   +3 more
doaj   +1 more source

Anti‐Cancer, Anti‐Inflammatory, and Analgesic Effects of Taxus wallichaina Extracts and Its Biosynthesized Silver Nanoparticles

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Taxus wallichaina extracts and its biosynthesized silver nanoparticles shows promising anticancer and anti‐inflammatory properties. ABSTRACT This study investigates the green synthesis of silver nanoparticles (AgNPs) using Taxus wallichiana Zucc. and evaluates their pharmacological potential.
Fazli Hadi, Waqar Ahmad Kaleem, Abdur Rauf, Anees Ahmed Khalil, Huda Ateeq, Ahood Khalid, Naveed Muhammad, Walaa F. Alsanie, Abdulhakeem S. Alamri, Amal F. Alshammary, Muhammad Ibrahim, Mohammed Mansour Quradha   +11 more
wiley   +1 more source