Profiling of Taxoid Compounds in Plant Cell Cultures of Different Species of Yew (Taxus spp.) [PDF]
Molecules, 2023 Plant cell cultures of various yew species are a profitable source of taxoids (taxane diterpenoids) with antitumor activity. So far, despite intensive studies, the principles of the formation of different groups of taxoids in cultured in vitro plant ...
Dmitry V. Kochkin +3 more
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Pelophen B is a non-taxoid binding microtubule-stabilizing agent with promising preclinical anticancer properties [PDF]
Scientific ReportsTaxanes, such as paclitaxel (PTX), stabilize microtubules and are used as a first-line therapy in multiple cancer types. Disruption of microtubule equilibrium, which plays an essential role in mitosis and cell homeostasis, ultimately results in cell ...
Stephanie Vermeulen +18 more
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Effect of Methyl Jasmonate on the Growth and Biosynthesis of C13- and C14-Hydroxylated Taxoids in the Cell Culture of Yew (Taxus wallichiana Zucc.) of Different Ages [PDF]
Biomolecules, 2023 The effects of methyl jasmonate (MeJ) on growth and taxoid formation in the cell culture of Taxus wallichiana were investigated to elucidate the specifics of phytohormone action in dedifferentiated plant cells in vitro.
Elena Demidova +4 more
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Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers [PDF]
Molecules, 2023 Novel 13α-estrone derivatives have been synthesized via direct arylation of the phenolic hydroxy function. Chan–Lam couplings of arylboronic acids with 13α-estrone as a nucleophilic partner were carried out under copper catalysis.
Édua Kovács +8 more
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Developed network between taxoid and phenylpropanoid pathways in Cryptosporiopsis tarraconensis, taxan-producing endophytic fungus by Debiased Sparse Partial Correlation (DSPC) algorithm. [PDF]
PLoS ONE, 2023 Although bioproduction of Paclitaxel by endophytic fungi is highly considered as an alternative promising source, but its yield is usually very low in comparison with other taxoids.
Narjes Mohammadi Ballakuti +1 more
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Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol [PDF]
Nature CommunicationsTaxol is a widely-applied anticancer drug that inhibits microtubule dynamics in actively replicating cells. Although a minimum 19-step biosynthetic pathway has been proposed and 16 enzymes likely involved have been characterized, stepwise biosynthetic ...
Chengshuai Yang +9 more
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Taxoid profile in endophytic fungi isolated from Corylus avellana, introduces potential source for the production of Taxol in semi-synthetic approaches [PDF]
Scientific Reports, 2022 Taxol (Paclitaxel) and its derivative taxanes are widely used in chemotherapy and treatment of different types of cancer. Although the extracted taxanes from Taxus sp. are currently used in semi-synthetic production of Taxol, providing alternative always
Narjes Mohammadi Ballakuti +5 more
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Optimization of the fermentation media, mathematical modeling, and enhancement of paclitaxel production by Alternaria alternata after elicitation with pectin [PDF]
Scientific ReportsAlternaria alternata fungus is a potent paclitaxel producer isolated from Corylus avellana. The major challenge is the lack of optimized media for endophytic fungi productivity. In the effort to maximize the production of taxoids by A. alternata, several
Hamzeh Rezazadeh +4 more
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Comparative metabolomic analysis reveals the variations in taxoids and flavonoids among three Taxus species [PDF]
BMC Plant Biology, 2019 Background Trees of the genus Taxus are highly valuable medicinal plants with multiple pharmacological effects on various cancer treatments. Paclitaxel from Taxus trees is an efficient and widely used anticancer drug, however, the accumulation of taxoids
Ting Zhou +10 more
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Evaluating Molecular Mechanism of Viral Inhibition of Aerosolized Smart Nano-Enabled Antiviral Therapeutic (SNAT) on SARS-CoV-2-Infected Hamsters [PDF]
ToxicsSmart Nano-enabled Antiviral Therapeutic (SNAT) is a promising nanodrug that previously demonstrated efficacy in preclinical studies to alleviate SARS-CoV-2 pathology in hamsters.
Anais N. Bauer +7 more
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