Results 31 to 40 of about 2,931 (217)
Chemistry & Biology, 1996 Taxol is a natural product produced by the Pacific Yew, Taxus brevifolia, that has emerged as a prominent chemotherapeutic agent for the treatment of solid tumors. Taxol's biochemical mode of action has been well studied: it binds to microtubules, stabilizing them and preventing their depolymerization to tubulin subunits.
Guy, R.K. +3 more
openaire +2 more sources
Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention
BioMed Research International, Volume 2022, Issue 1, 2022., 2022 Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years.
Arif Jamal Siddiqui +11 more
wiley +1 more source
BioResources, 2023 Yew tree (Taxus baccata L.) is mainly populated in Türkiye, Europe, and Caucasia regions. It has natural anticancer compounds and is a source of raw materials used in modern medicine.
Mesut Tandogan +3 more
doaj +2 more sources
BMC Plant Biology, 2019 Background Taxol is an efficient anticancer drug; however, the accumulation of taxoids can vary hugely among Taxus species. The mechanism underlying differential accumulation of taxoids is largely unknown. Thus, comparative analysis of the transcriptomes
Ting Zhou +7 more
doaj +1 more source
Role of Taxoids in Head and Neck Cancer [PDF]
The Oncologist, 2000 Abstract Docetaxel and paclitaxel represent a new class of cytotoxic agents having both a specific chemical structure and mechanism of action. They act to promote tubulin polymerization and the formation of stable microtubules. The microtubules produced in the presence of taxoids are resistant to disassembly by physiologic stimuli, and ...
Schrijvers, D., Vermorken, J.B.
openaire +3 more sources
Structural intermediates in the assembly of taxoid-induced microtubules and GDP-tubulin double rings: time-resolved X-ray scattering [PDF]
, 1996 We have studied the self-association reactions of purified GDP-liganded tubulin into double rings and taxoid-induced microtubules, employing synchrotron time-resolved x-ray solution scattering.
Diaz, J.F. +4 more
core +1 more source
Molecular Cancer Therapeutics, 2019 The goal of this study was to evaluate combination of a novel taxoid, DHA-SBT-1214 chemotherapy, in modulating immune checkpoint marker expression and ultimately in improving antibody-based checkpoint blockade therapy in pancreatic adenocarcinoma (PDAC).
Gulzar Ahmad +3 more
semanticscholar +1 more source
Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery
Journal of Natural Products, 2018 Paclitaxel and docetaxel are among the most widely used chemotherapeutic drugs against various types of cancer. However, these drugs cause undesirable side effects as well as drug resistance.
I. Ojima +3 more
semanticscholar +1 more source
Direct visualization of the microtubular cytoskeleton of ciliated protozoa with a fluorescent taxoid
, 2021 Visualization of the infraciliature, which is an essential tool for the identification of ciliate species, has traditionally been obtained with silver proteinate methods.
Arregui, Lucía +4 more
core +1 more source
Pharmaceutical Research, 2018 The main purpose of this study was to formulate an oil-in-water nanoemulsion of a next generation taxoid DHA-SBT-1214 and evaluate its biodistribution and pharmacokinetics.
Gulzar Ahmad +6 more
semanticscholar +1 more source