Results 31 to 40 of about 1,290 (186)
, 2015 An approach to construct enantiopure complex natural product-like frameworks, including the first reported synthesis of a C17 oxygenated taxoid scaffold, is presented.
Ahmad Masarwa (1491013) +3 more
core +2 more sources
Neoplasia: An International Journal for Oncology Research, 2008 Several naphthalimides have been evaluated clinically as potential anticancer agents. UNBS3157, a naphthalimide that belongs to the same class as amonafide, was designed to avoid the specific activating metabolism that induces amonafide’s hematotoxicity.
Tatjana Mijatovic +13 more
doaj +1 more source
Tumor-Specific Novel Taxoid−Monoclonal Antibody Conjugates
, 2016 Taxoids bearing methyldisulfanyl(alkanoyl) groups for taxoid−antibody immunoconjugates were designed, synthesized and their activities evaluated. A highly cytotoxic C-10 methyldisulfanylpropanoyl taxoid was conjugated to monoclonal antibodies recognizing
Victor S. Goldmacher (691791) +10 more
core +1 more source
Taxol Biosynthesis Molecular Cloning and Characterization of a Cytochrome P450 Taxoid 7β-Hydroxylase
, 2004 Biosynthesis of the anticancer drug Taxol in yew species involves eight cytochrome P450-mediated oxygenations and four coenzyme A-dependent acylations of the diterpenoid core. A family of cytochrome P450 genes, obtained from a yew cell cDNA library, were
Jennewein, Stefan +3 more
core +1 more source
, 2013 The enzyme taxoid 14β-hydroxylase (14OH) directs a side-route of taxol pathway to 14β-hydroxy taxoids. Suppression of this side-route could increase the production of taxol.
Dai, JG +5 more
core +1 more source
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites
, 2013 Cyclostreptin (1), a natural product from Streptomyces sp. 9885, irreversibly stabilizes cellular microtubules, causes cell cycle arrest, evades drug resistance mediated by P-glycoprotein in a tumor cell line and potently inhibits paclitaxel binding to ...
Hamel, Ernest +13 more
core +1 more source
Plant Biotechnology Journal, Volume 24, Issue 5, Page 3308-3323, May 2026.ABSTRACT 7‐β‐xylosyl‐10‐deacetyltaxol (XDT) is much more abundant than the anticancer drug Taxol in Taxus species and is usually regarded as the by‐product of Taxol. It could be enzymatically transformed into 10‐deacetyltaxol (DT), and the latter could be further converted into Taxol.
Tian‐Jiao Chen +5 more
wiley +1 more source
Design and Synthesis of a Taxoid Library Using Radiofrequency Encoded Combinatorial Chemistry
, 2016 Radiofrequency encoded combinatorial (REC) chemistry is a recently developed nonchemical encoding strategy in library synthesis. Encoded chemical libraries of complex molecular structures like Taxol can be constructed employing the noninvasive REC ...
Xiao (3209220) +2 more
core +1 more source
An Unusual Case Presentation on Docetaxel Induced Lung Injury
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT Docetaxel can rarely cause acute interstitial lung injury early in therapy. New‐onset cough, fever, or dyspnea after chemotherapy should prompt immediate evaluation, exclusion of infection, and high‐resolution CT imaging. Early drug withdrawal and timely corticosteroid therapy can result in rapid clinical recovery and prevent serious morbidity.
Soorej Balan Kaliyath +7 more
wiley +1 more source
, 1996 We have studied the self-association reactions of purified GDP-liganded tubulin into double rings and taxoid-induced microtubules, employing synchrotron time-resolved x-ray solution scattering.
Diaz, J.F. +6 more
core +1 more source