Results 11 to 20 of about 1,290 (186)

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol. [PDF]

Angew Chem Int Ed Engl
A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Kudalkar GP, Leidner F, Kumar N, Hass JL, Madzelan P, Powell DR, Day VW, Magueres PL, Ferrara JD, Daniels LM, Yamano A, Ito S, Niu W, Grubmüller H, Wilson MA, Berkowitz DB.   +15 more
europepmc   +5 more sources

Analysis of MS/MS Fragmentation of Taxoids [PDF]

Natural Product Communications, 2010
The fragmentation pathways of seven types of taxoids were investigated by using a LC-MS/MS method, namely: (1) neutral taxoids with a C-4(20) double bond; (2) taxoids with a C-4(20) double bond and oxygenation at C-14; (3) 5-cinnamoyl taxoids with a C-4 ...
Kouhei Morikawa, Ken Tanaka, Feng Li, Suresh Awale, Yasuhiro Tezuka, Takahiro Nobukawa, Shigetoshi Kadota   +6 more
doaj   +3 more sources

Fluorescent Taxoid Probes for Microtubule Research

, 2010
The use of the antitumor drug taxol as an experimental microtubule-stabilizing agent is widespread. Fluorescent taxol conjugates, although less employed, are very useful tools for several purposes in microtubule research. These include easily visualizing microtubule cytoskeletons in a variety of cells as well as in vitro assembled microtubules ...
Barasoain, Isabel, Díaz, José Fernando, Andreu, José Manuel   +2 more
openaire   +4 more sources

New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells [PDF]

Molecular Cancer, 2010
Background Growing evidence suggests that the majority of tumors are organized hierarchically, comprising a population of tumor-initiating, or cancer stem cells (CSCs) responsible for tumor development, maintenance and resistance to drugs.
Rowehl Rebecca A, Savitt Anne G, Zhu Shu, Wang Hichao, Wang Yuan, Das Manisha, Zuniga Edison S, Botchkina Galina I, Leyfman Yan, Ju Jingfang, Shroyer Kenneth, Ojima Iwao   +11 more
doaj   +2 more sources

Paclitaxel biological synthesis promotes the innovation of anti-cancer drugs. [PDF]

Clin Transl Med
Clinical and Translational Medicine, Volume 15, Issue 2, February 2025.
Zhang X, Liu G, Yan J.
europepmc   +2 more sources

Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-(N-benzyltriazolylmethyl)-13α-oestrone derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
2- or 4-Substituted 3-N-benzyltriazolylmethyl-13α-oestrone derivatives were synthesised via bromination of ring A and subsequent microwave-assisted, Pd-catalysed C(sp2)–P couplings. The antiproliferative activities of the newly synthesised brominated and
Rebeka Jójárt, Seyyed Ashkan Senobar Tahaei, Péter Trungel-Nagy, Zoltán Kele, Renáta Minorics, Gábor Paragi, István Zupkó, Erzsébet Mernyák   +7 more
doaj   +1 more source

Electrosynthetic C−O Bond Activation in Alcohols and Alcohol Derivatives

Angewandte Chemie, Volume 135, Issue 4, January 23, 2023., 2023
Deoxygenative transformations of alcohols and their derivatives are often challenging due to the thermodynamic penalty associated with the cleavage of the C−O bond. This Review includes preparative protocols and their mechanistic aspects for the activation and functionalization of C−O bonds, detailing direct and indirect electrosynthetic methods, as ...
Piret Villo, Andrey Shatskiy, Markus D. Kärkäs, Helena Lundberg   +3 more
wiley   +2 more sources

Electroreductive Deoxygenative C−H and C−C Bond Formation from Non‐Derivatized Alcohols Fueled by Anodic Borohydride Oxidation

ChemElectroChem, Volume 10, Issue 22, November 14, 2023., 2023
Herein, electroreductive C−OH bond activation and subsequent deoxygenative C−H and C−C bond formation is demonstrated for non‐derivatized benzylic and propargylic alcohols. The cathodic transformations proceed via carbanions, formed via radical‐polar crossover, and are efficiently balanced by anodic oxidation of borohydride additives, a strategy that ...
Piret Villo, Malin Lill, Zainab Alsaman, Adrian Soto Kronberg, Victoria Chu, Guillermo Ahumada, Hemlata Agarwala, Mårten Ahlquist, Helena Lundberg   +8 more
wiley   +1 more source

Docetaxel Loaded in Copaiba Oil-Nanostructured Lipid Carriers as a Promising DDS for Breast Cancer Treatment

Molecules, 2022
Breast cancer is the neoplasia of highest incidence in women worldwide. Docetaxel (DTX), a taxoid used to treat breast cancer, is a BCS-class-IV compound (low oral bioavailability, solubility and intestinal permeability). Nanotechnological strategies can
Fabiola Vieira de Carvalho, Ligia Nunes de Morais Ribeiro, Ludmilla David de Moura, Gustavo Henrique Rodrigues da Silva, Hery Mitsutake, Talita Cesarim Mendonça, Gabriela Geronimo, Marcia Cristina Breitkreitz, Eneida de Paula   +8 more
doaj   +1 more source

Synthesis and Structure‐Activity Relationship Studies of C(13)‐Desmethylene‐(−)‐Zampanolide Analogs

Chemistry – A European Journal, Volume 29, Issue 36, June 27, 2023., 2023
Reduced or demethylated variants of a C(13)‐desmethylene congener of the marine microtubule stabilizer (−)‐zampanolide have been prepared by HWE‐based macrocyclization and stereoselective construction of the hemiaminal center in the side chain. While all modifications led to reduced growth inhibitory activity, the 2,3‐dihydro and the C(17)‐desmethyl ...
Tobias M. Brütsch, Etienne Cotter, Daniel Lucena‐Agell, Mariano Redondo‐Horcajo, Carolina Davies, Bernhard Pfeiffer, Sandro Pagani, Simone Berardozzi, J. Fernando Díaz, John H. Miller, Karl‐Heinz Altmann   +10 more
wiley   +1 more source