Results 11 to 20 of about 2,931 (217)

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol. [PDF]

Angew Chem Int Ed Engl
These studies reveal the first structure of Clostridium acetobutylicum alcohol dehydrogenase (CaADH), a protein exhibiting remarkable substrate promiscuity and stereochemical fidelity.
Kudalkar GP, Leidner F, Kumar N, Hass JL, Madzelan P, Powell DR, Day VW, Magueres PL, Ferrara JD, Daniels LM, Yamano A, Ito S, Niu W, Grubmüller H, Wilson MA, Berkowitz DB.   +15 more
europepmc   +6 more sources

Fluorescent taxoid probes for microtubule research.

Methods in Cell Biology, 2010
The use of the antitumor drug taxol as an experimental microtubule-stabilizing agent is widespread. Fluorescent taxol conjugates, although less employed, are very useful tools for several purposes in microtubule research. These include easily visualizing microtubule cytoskeletons in a variety of cells as well as in vitro assembled microtubules ...
I. Barasoaín, J. F. Díaz, J. Andreu
semanticscholar   +5 more sources

Construction of Enantiopure Taxoid and Natural Product-like Scaffolds Using a C-C Bond Cleavage/Arylation Reaction.

Organic Letters, 2015
An approach to construct enantiopure complex natural product-like frameworks, including the first reported synthesis of a C17 oxygenated taxoid scaffold, is presented.
M. Weber, Kyle R. Owens, A. Masarwa, Richmond Sarpong   +3 more
semanticscholar   +3 more sources

Identification of potential genes that contributed to the variation in the taxoid contents between two Taxus species (Taxus media and Taxus mairei)

Tree Physiology, 2017
Taxol is currently a valuable anticancer drug; however, the accumulated mixture of taxoids can vary greatly among Taxus species. So far, there is very little genomic information for the genus Taxus, except for Taxus baccata.
Chunna Yu, Hong Guo, Yangyang Zhang, Yao-Bin Song, E. Pi, Chen-Liang Yu, Lei Zhang, Ming Dong, Bing-Song Zheng, Hui-Zhong Wang, C. Shen   +10 more
semanticscholar   +2 more sources

Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24. [PDF]

PLoS ONE, 2013
Prostate cancer is the second leading cause of cancer death among men. Multiple evidence suggests that a population of tumor-initiating, or cancer stem cells (CSCs) is responsible for cancer development and exceptional drug resistance, representing a ...
Galina I Botchkina, Edison S Zuniga, Rebecca H Rowehl, Rosa Park, Rahuldev Bhalla, Agnieszka B Bialkowska, Francis Johnson, Lorne M Golub, Yu Zhang, Iwao Ojima, Kenneth R Shroyer   +10 more
doaj   +2 more sources

Analysis of MS/MS Fragmentation of Taxoids [PDF]

Natural Product Communications, 2010
The fragmentation pathways of seven types of taxoids were investigated by using a LC-MS/MS method, namely: (1) neutral taxoids with a C-4(20) double bond; (2) taxoids with a C-4(20) double bond and oxygenation at C-14; (3) 5-cinnamoyl taxoids with a C-4 ...
Kouhei Morikawa, Ken Tanaka, Feng Li, Suresh Awale, Yasuhiro Tezuka, Takahiro Nobukawa, Shigetoshi Kadota   +6 more
doaj   +3 more sources

New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells

Molecular Cancer, 2010
Background Growing evidence suggests that the majority of tumors are organized hierarchically, comprising a population of tumor-initiating, or cancer stem cells (CSCs) responsible for tumor development, maintenance and resistance to drugs.
Rowehl Rebecca A, Savitt Anne G, Zhu Shu, Wang Hichao, Wang Yuan, Das Manisha, Zuniga Edison S, Botchkina Galina I, Leyfman Yan, Ju Jingfang, Shroyer Kenneth, Ojima Iwao   +11 more
doaj   +2 more sources

Antisense-induced suppression of taxoid 14 β- hydroxylase gene expression in transgenic Taxus × media cells [PDF]

, 2011
The enzyme taxoid 14β-hydroxylase (14OH) directs a side-route of taxol pathway to 14β-hydroxy taxoids. Suppression of this side-route could increase the production of taxol.
Feng-Lan Li, Xiao-Jun Ma, Xinling Hu, A. Hoffman, Jun-Gui Dai, De-You Qiu   +5 more
semanticscholar   +2 more sources

Recent advances in the strategic incorporation of fluorine into new-generation taxoid anticancer agents. [PDF]

J Fluor Chem, 2023
This account describes our recent progress on the strategic incorporation of fluorine and organofluorine moieties into new-generation taxoid anticancer agents for medicinal chemistry and chemical biology studies. In the case study 1, novel 3rd-generation
Jayanetti K, Takemura K, Bendale H, Garg A, Ojima I.   +4 more
europepmc   +2 more sources

Paclitaxel biological synthesis promotes the innovation of anti-cancer drugs. [PDF]

Clin Transl Med
Clinical and Translational Medicine, Volume 15, Issue 2, February 2025.
Zhang X, Liu G, Yan J.
europepmc   +2 more sources