Results 21 to 30 of about 1,290 (186)

Role of Taxoids in Head and Neck Cancer [PDF]

The Oncologist, 2000
Abstract Docetaxel and paclitaxel represent a new class of cytotoxic agents having both a specific chemical structure and mechanism of action. They act to promote tubulin polymerization and the formation of stable microtubules. The microtubules produced in the presence of taxoids are resistant to disassembly by physiologic stimuli, and ...
Schrijvers, D., Vermorken, J.B.
openaire   +3 more sources

Response of Patients with Taxane‐Refractory Advanced Urothelial Cancer to Enfortumab Vedotin, a Microtubule‐Disrupting Agent

Case Reports in Urology, Volume 2023, Issue 1, 2023., 2023
Enfortumab vedotin (EV), a nectin‐4‐directed antibody conjugated to monomethyl auristatin E (MMAE), has been approved for patients with advanced urothelial carcinoma (aUC) previously treated with platinum‐based chemotherapy and immune inhibitors. Taxane agents and MMAE share antitumor mechanisms through microtubule disruption, thus raising a notable ...
Makito Miyake, Nobutaka Nishimura, Tatsuki Miyamoto, Takuto Shimizu, Kenta Ohnishi, Shunta Hori, Yosuke Morizawa, Daisuke Gotoh, Yasushi Nakai, Kazumasa Torimoto, Tomomi Fujii, Kiyohide Fujimoto, Fumitaka Koga   +12 more
wiley   +1 more source

Perspective of a new diagnostic for human trichomonosis

Memorias do Instituto Oswaldo Cruz, 2003
Several diagnostic techniques have been employed for the detection of Trichomonas vaginalis. Microtubules constitute the cytoskeleton in eukaryotic cells and are sensitive to antimitotic drugs, such as Taxol (paclitaxel).
Sheila B Lecke, Tiana Tasca, André A Souto, Geraldo A De Carli   +3 more
doaj   +1 more source

Fluorescent taxoids

Chemistry & Biology, 1996
Taxol is a natural product produced by the Pacific Yew, Taxus brevifolia, that has emerged as a prominent chemotherapeutic agent for the treatment of solid tumors. Taxol's biochemical mode of action has been well studied: it binds to microtubules, stabilizing them and preventing their depolymerization to tubulin subunits.
Guy, R.K., Scott, Z.A., Sloboda, R.D., Nicolaou, K.C.   +3 more
openaire   +2 more sources

Activities and Molecular Mechanisms of Diterpenes, Diterpenoids, and Their Derivatives in Rheumatoid Arthritis

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Diterpenes and their derivatives have many biological activities, including anti‐inflammatory and immunomodulatory effects. To date, several diterpenes, diterpenoids, and their laboratory‐derived products have been demonstrated for antiarthritic activities.
Muhammad Torequl Islam, Cristina Quispe, Jesús Herrera-Bravo, Md. Mizanur Rahaman, Rajib Hossain, Chandan Sarkar, Md Abdur Raihan, Md. Mashrur Chowdhury, Shaikh Jamal Uddin, Jamil A. Shilpi, João Marcelo de Castro e Sousa, Ana Amélia de Carvalho Melo-Cavalcante, Mohammad S. Mubarak, Javad Sharifi-Rad, Daniela Calina, Yanhong Zhu   +15 more
wiley   +1 more source

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years.
Arif Jamal Siddiqui, Sadaf Jahan, Ritu Singh, Juhi Saxena, Syed Amir Ashraf, Andleeb Khan, Ranjay Kumar Choudhary, Santhanaraj Balakrishnan, Riadh Badraoui, Fevzi Bardakci, Mohd Adnan, Yearul Kabir   +11 more
wiley   +1 more source

Determining the Taxol Contents of Yew Tree Populations in Western Black Sea and Marmara Regions and Analyzing Some Forest Stand Characteristics

BioResources, 2023
Yew tree (Taxus baccata L.) is mainly populated in Türkiye, Europe, and Caucasia regions. It has natural anticancer compounds and is a source of raw materials used in modern medicine.
Mesut Tandogan, Halil Barış Özel, Fatma Tuba Gözet, Hakan Sevik   +3 more
doaj   +2 more sources

Transcriptome analyses provide insights into the expression pattern and sequence similarity of several taxol biosynthesis-related genes in three Taxus species

BMC Plant Biology, 2019
Background Taxol is an efficient anticancer drug; however, the accumulation of taxoids can vary hugely among Taxus species. The mechanism underlying differential accumulation of taxoids is largely unknown. Thus, comparative analysis of the transcriptomes
Ting Zhou, Xiujun Luo, Chunna Yu, Chengchao Zhang, Lei Zhang, Yao-bin Song, Ming Dong, Chenjia Shen   +7 more
doaj   +1 more source

Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24. [PDF]

PLoS ONE, 2013
Prostate cancer is the second leading cause of cancer death among men. Multiple evidence suggests that a population of tumor-initiating, or cancer stem cells (CSCs) is responsible for cancer development and exceptional drug resistance, representing a ...
Galina I Botchkina, Edison S Zuniga, Rebecca H Rowehl, Rosa Park, Rahuldev Bhalla, Agnieszka B Bialkowska, Francis Johnson, Lorne M Golub, Yu Zhang, Iwao Ojima, Kenneth R Shroyer   +10 more
doaj   +1 more source

Direct visualization of the microtubular cytoskeleton of ciliated protozoa with a fluorescent taxoid

, 2021
Visualization of the infraciliature, which is an essential tool for the identification of ciliate species, has traditionally been obtained with silver proteinate methods.
Arregui, Lucía, Guinea, Almudena, Muñoz-Fontela, César, Serrano, Susana, Barasoain, Isabel   +4 more
core   +1 more source