Results 21 to 30 of about 2,931 (217)

Integrated mass spectrometry imaging and single-cell transcriptome atlas strategies provide novel insights into taxoid biosynthesis and transport in Taxus mairei stems.

The Plant Journal, 2023
Taxol, which is an widely used important chemotherapeutic agent, which was originally isolated from Taxus stem barks. However, the precise distribution of taxoids and the transcriptional regulation of taxoid biosynthesis across Taxus stems are largely ...
Chunna Yu, Kai-Lin Hou, Hong-Shan Zhang, Xue-Shuang Liang, Cheng Chen, Zhi-Jing Wang, Qi-Cong Wu, Ganlin Chen, Jiaxu He, En-Hui Bai, Xinfen Li, Ting Du, Yi-Fan Wang, Ming-Shuang Wang, Shang-Guo Feng, Hui-Zhong Wang, C. Shen   +16 more
semanticscholar   +1 more source

Docetaxel

, 1997
Paclitaxel was the first taxoid to become available. It was found to be an active anticancer agent but with significant toxicity. Docetaxel is a semisynthetic taxoid and the next of a fast-expanding class of drugs.
Leahy, M, Howell, A; id_orcid
core   +8 more sources

Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-(N-benzyltriazolylmethyl)-13α-oestrone derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
2- or 4-Substituted 3-N-benzyltriazolylmethyl-13α-oestrone derivatives were synthesised via bromination of ring A and subsequent microwave-assisted, Pd-catalysed C(sp2)–P couplings. The antiproliferative activities of the newly synthesised brominated and
Rebeka Jójárt, Seyyed Ashkan Senobar Tahaei, Péter Trungel-Nagy, Zoltán Kele, Renáta Minorics, Gábor Paragi, István Zupkó, Erzsébet Mernyák   +7 more
doaj   +1 more source

Electrosynthetic C−O Bond Activation in Alcohols and Alcohol Derivatives

Angewandte Chemie, Volume 135, Issue 4, January 23, 2023., 2023
Deoxygenative transformations of alcohols and their derivatives are often challenging due to the thermodynamic penalty associated with the cleavage of the C−O bond. This Review includes preparative protocols and their mechanistic aspects for the activation and functionalization of C−O bonds, detailing direct and indirect electrosynthetic methods, as ...
Piret Villo, Andrey Shatskiy, Markus D. Kärkäs, Helena Lundberg   +3 more
wiley   +2 more sources

Electroreductive Deoxygenative C−H and C−C Bond Formation from Non‐Derivatized Alcohols Fueled by Anodic Borohydride Oxidation

ChemElectroChem, Volume 10, Issue 22, November 14, 2023., 2023
Herein, electroreductive C−OH bond activation and subsequent deoxygenative C−H and C−C bond formation is demonstrated for non‐derivatized benzylic and propargylic alcohols. The cathodic transformations proceed via carbanions, formed via radical‐polar crossover, and are efficiently balanced by anodic oxidation of borohydride additives, a strategy that ...
Piret Villo, Malin Lill, Zainab Alsaman, Adrian Soto Kronberg, Victoria Chu, Guillermo Ahumada, Hemlata Agarwala, Mårten Ahlquist, Helena Lundberg   +8 more
wiley   +1 more source

Synthesis and Structure‐Activity Relationship Studies of C(13)‐Desmethylene‐(−)‐Zampanolide Analogs

Chemistry – A European Journal, Volume 29, Issue 36, June 27, 2023., 2023
Reduced or demethylated variants of a C(13)‐desmethylene congener of the marine microtubule stabilizer (−)‐zampanolide have been prepared by HWE‐based macrocyclization and stereoselective construction of the hemiaminal center in the side chain. While all modifications led to reduced growth inhibitory activity, the 2,3‐dihydro and the C(17)‐desmethyl ...
Tobias M. Brütsch, Etienne Cotter, Daniel Lucena‐Agell, Mariano Redondo‐Horcajo, Carolina Davies, Bernhard Pfeiffer, Sandro Pagani, Simone Berardozzi, J. Fernando Díaz, John H. Miller, Karl‐Heinz Altmann   +10 more
wiley   +1 more source

Docetaxel Loaded in Copaiba Oil-Nanostructured Lipid Carriers as a Promising DDS for Breast Cancer Treatment

Molecules, 2022
Breast cancer is the neoplasia of highest incidence in women worldwide. Docetaxel (DTX), a taxoid used to treat breast cancer, is a BCS-class-IV compound (low oral bioavailability, solubility and intestinal permeability). Nanotechnological strategies can
Fabiola Vieira de Carvalho, Ligia Nunes de Morais Ribeiro, Ludmilla David de Moura, Gustavo Henrique Rodrigues da Silva, Hery Mitsutake, Talita Cesarim Mendonça, Gabriela Geronimo, Marcia Cristina Breitkreitz, Eneida de Paula   +8 more
doaj   +1 more source

Response of Patients with Taxane‐Refractory Advanced Urothelial Cancer to Enfortumab Vedotin, a Microtubule‐Disrupting Agent

Case Reports in Urology, Volume 2023, Issue 1, 2023., 2023
Enfortumab vedotin (EV), a nectin‐4‐directed antibody conjugated to monomethyl auristatin E (MMAE), has been approved for patients with advanced urothelial carcinoma (aUC) previously treated with platinum‐based chemotherapy and immune inhibitors. Taxane agents and MMAE share antitumor mechanisms through microtubule disruption, thus raising a notable ...
Makito Miyake, Nobutaka Nishimura, Tatsuki Miyamoto, Takuto Shimizu, Kenta Ohnishi, Shunta Hori, Yosuke Morizawa, Daisuke Gotoh, Yasushi Nakai, Kazumasa Torimoto, Tomomi Fujii, Kiyohide Fujimoto, Fumitaka Koga   +12 more
wiley   +1 more source

Perspective of a new diagnostic for human trichomonosis

Memorias do Instituto Oswaldo Cruz, 2003
Several diagnostic techniques have been employed for the detection of Trichomonas vaginalis. Microtubules constitute the cytoskeleton in eukaryotic cells and are sensitive to antimitotic drugs, such as Taxol (paclitaxel).
Sheila B Lecke, Tiana Tasca, André A Souto, Geraldo A De Carli   +3 more
doaj   +1 more source

Activities and Molecular Mechanisms of Diterpenes, Diterpenoids, and Their Derivatives in Rheumatoid Arthritis

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Diterpenes and their derivatives have many biological activities, including anti‐inflammatory and immunomodulatory effects. To date, several diterpenes, diterpenoids, and their laboratory‐derived products have been demonstrated for antiarthritic activities.
Muhammad Torequl Islam, Cristina Quispe, Jesús Herrera-Bravo, Md. Mizanur Rahaman, Rajib Hossain, Chandan Sarkar, Md Abdur Raihan, Md. Mashrur Chowdhury, Shaikh Jamal Uddin, Jamil A. Shilpi, João Marcelo de Castro e Sousa, Ana Amélia de Carvalho Melo-Cavalcante, Mohammad S. Mubarak, Javad Sharifi-Rad, Daniela Calina, Yanhong Zhu   +15 more
wiley   +1 more source