Results 41 to 50 of about 1,290 (186)

Gender influences the taxanes content in different organs of European yew tree (Taxus baccata L.) in the Hyrcanian forests

Trees, Forests and People
European yew (Taxus baccata L.), the main natural source of anticancer taxanes, is an evergreen and dioecious tree native to northern Iran at the Hyrcanian ecoregion forests.
Arghavan Hematzadeh, Omid Esmailzadeh, Hamed Yousefzadeh, Mohammad Hossein Mirjalili   +3 more
doaj   +1 more source

Orthoquinone, Cyclic, and Acyclic α‐Diketone Natural Products: From Food Applications to Pharmacotherapy

Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.
The orthoquinone metabolites from plants have antimicrobial, antioxidant, antiviral, cytotoxic, and anti‐inflammatory effects. ABSTRACT The structural diversity of natural products is vast and fascinating, and they have been recognized as an enormously diverse source of new lead compounds.
Hidayat Hussain, Daijie Wang, Satyajit D. Sarker, Lutfun Nahar, Nilufar Z. Mamadalieva, Jianbo Xiao   +5 more
wiley   +1 more source

Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid

, 2006
A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids.
Ferjančić, Zorana, Saičić, Radomir, Trajković, Vladimir, Trajković, Vladimir S., Matović, Radomir, Snyder, James P., Jiang, Yi, Čeković, Živorad, Saičić, Radomir N.   +8 more
core   +1 more source

Pacific Blue Derivatives of Paclitaxel as Fluorescent Probes of OATP1B‐Type Transporters

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Paclitaxel (Taxol) is a widely used anticancer agent that undergoes extensive hepatic metabolism and that causes a debilitating, dose‐limiting peripheral neurotoxicity. We previously reported that the uptake of paclitaxel in hepatocytes and dorsal root ganglion neurons, the site of injury within the nervous system, is mediated by the organic ...
Mahesh R. Nepal, Yue Xu, Yan Jin, Peng Hu, Xiaojun Hu, Digamber S. Rane, Angelo E. Andres, Eman A. Ahmed, Brandon Steiger, Alex Sparreboom, Blake R. Peterson, Shuiying Hu   +11 more
wiley   +1 more source

Identification of potential genes that contributed to the variation in the taxoid contents between two Taxus species (Taxus media and Taxus mairei)

, 2017
Taxol is currently a valuable anticancer drug; however, the accumulated mixture of taxoids can vary greatly among Taxus species. So far, there is very little genomic information for the genus Taxus, except for Taxus baccata.
Bingsong Zheng, Chenliang Yu, Yaobin Song, Huizhong Wang, Chunna Yu, Erxu Pi, Hong Guo, Chenjia Shen, Lei Zhang, Ming Dong, Yangyang Zhang   +10 more
core   +1 more source

Anti‐Cancer, Anti‐Inflammatory, and Analgesic Effects of Taxus wallichaina Extracts and Its Biosynthesized Silver Nanoparticles

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Taxus wallichaina extracts and its biosynthesized silver nanoparticles shows promising anticancer and anti‐inflammatory properties. ABSTRACT This study investigates the green synthesis of silver nanoparticles (AgNPs) using Taxus wallichiana Zucc. and evaluates their pharmacological potential.
Fazli Hadi, Waqar Ahmad Kaleem, Abdur Rauf, Anees Ahmed Khalil, Huda Ateeq, Ahood Khalid, Naveed Muhammad, Walaa F. Alsanie, Abdulhakeem S. Alamri, Amal F. Alshammary, Muhammad Ibrahim, Mohammed Mansour Quradha   +11 more
wiley   +1 more source

Alkyne zip reaction in the synthesis of a taxoid C-ring

, 2000
International audienceHydrazone 30, precursor of a taxoid C-ring, was synthesized in 7 steps from commercial 2-methyl-1,3-cyclohexanedione. An enantioselective approach to 30 was also investigated, using a reduction of diketone 11 with bakers' yeast to ...
Lallemand, Jean-Yves, Prangé, T., Pancrazi, A., Bourgeois, Damien, Prunet, Joëlle   +4 more
core   +1 more source

Taxuspinanane G from the Aerial Parts of Taxus baccata L. Growing in Iran

Journal of Medicinal Plants, 2008
Background: The discovery of paclitaxel (Taxol®) as a potent anticancer drug from Taxus brevifolia has encouraged several groups all over the world to conduct research work on other Taxus species, in order to isolate potentially more effective paclitaxel
MR Verdian - Rizi, A Hadjiakhoondi, Sh Rezazadeh, M Khanavi, M Pirali - Hamedani   +4 more
doaj  

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, Volume 3, Issue 5, September 2025.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Design and synthetic approach to a taxoid analogue.

, 1998
The design and synthetic strategy towards a taxoid analogue that contains the important functional groups required for biological activity is described.
Mackintosh, Nicole Lea.
core   +1 more source