Results 41 to 50 of about 2,931 (217)
Antisense-induced suppression of taxoid 14β- hydroxylase gene expression in transgenic Taxus × media cells [PDF]
, 2013 The enzyme taxoid 14β-hydroxylase (14OH) directs a side-route of taxol pathway to 14β-hydroxy taxoids. Suppression of this side-route could increase the production of taxol.
Dai, JG +5 more
core +1 more source
Tumor-Specific Novel Taxoid−Monoclonal Antibody Conjugates
, 2016 Taxoids bearing methyldisulfanyl(alkanoyl) groups for taxoid−antibody immunoconjugates were designed, synthesized and their activities evaluated. A highly cytotoxic C-10 methyldisulfanylpropanoyl taxoid was conjugated to monoclonal antibodies recognizing
Victor S. Goldmacher (691791) +10 more
core +1 more source
BMC Plant Biology, 2019 Background Trees of the genus Taxus are highly valuable medicinal plants with multiple pharmacological effects on various cancer treatments. Paclitaxel from Taxus trees is an efficient and widely used anticancer drug, however, the accumulation of taxoids
Ting Zhou +10 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2008 Several naphthalimides have been evaluated clinically as potential anticancer agents. UNBS3157, a naphthalimide that belongs to the same class as amonafide, was designed to avoid the specific activating metabolism that induces amonafide’s hematotoxicity.
Tatjana Mijatovic +13 more
doaj +1 more source
Design and Synthesis of a Taxoid Library Using Radiofrequency Encoded Combinatorial Chemistry
, 2016 Radiofrequency encoded combinatorial (REC) chemistry is a recently developed nonchemical encoding strategy in library synthesis. Encoded chemical libraries of complex molecular structures like Taxol can be constructed employing the noninvasive REC ...
Xiao (3209220) +2 more
core +1 more source
Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid
, 2006 A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids.
Ferjančić, Zorana +8 more
core +1 more source
Plant Biotechnology Journal, Volume 24, Issue 5, Page 3308-3323, May 2026.ABSTRACT 7‐β‐xylosyl‐10‐deacetyltaxol (XDT) is much more abundant than the anticancer drug Taxol in Taxus species and is usually regarded as the by‐product of Taxol. It could be enzymatically transformed into 10‐deacetyltaxol (DT), and the latter could be further converted into Taxol.
Tian‐Jiao Chen +5 more
wiley +1 more source
An Unusual Case Presentation on Docetaxel Induced Lung Injury
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT Docetaxel can rarely cause acute interstitial lung injury early in therapy. New‐onset cough, fever, or dyspnea after chemotherapy should prompt immediate evaluation, exclusion of infection, and high‐resolution CT imaging. Early drug withdrawal and timely corticosteroid therapy can result in rapid clinical recovery and prevent serious morbidity.
Soorej Balan Kaliyath +7 more
wiley +1 more source
Trees, Forests and PeopleEuropean yew (Taxus baccata L.), the main natural source of anticancer taxanes, is an evergreen and dioecious tree native to northern Iran at the Hyrcanian ecoregion forests.
Arghavan Hematzadeh +3 more
doaj +1 more source
Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.The orthoquinone metabolites from plants have antimicrobial, antioxidant, antiviral, cytotoxic, and anti‐inflammatory effects. ABSTRACT The structural diversity of natural products is vast and fascinating, and they have been recognized as an enormously diverse source of new lead compounds.
Hidayat Hussain +5 more
wiley +1 more source