Results 61 to 70 of about 2,931 (217)

Design, synthesis, and biological evaluation of novel taxoid-based small-molecule theranostic PET/SPECT imaging agents and nano-scale asymmetric bow-tie dendrimer drug conjugates towards tumor-targeted chemotherapy [PDF]

, 2015
Cancer remains the second leading cause of death in the United States. Traditional chemotherapy relies on highly potent cytotoxic agents, such as paclitaxel and docetaxel, to kill rapidly dividing cancer cells.
Wang, Tao
core  

Three Decades of Taxanes: Exploring the Next Frontier

Scientia Pharmaceutica
Taxanes, such as paclitaxel and docetaxel, are microtubule-stabilizing agents widely used in oncology, either as monotherapy or in combination regimens.
Rita I. L. Catarino, Maria Fernanda C. Leal, Adriana M. Pimenta, Maria Renata S. Souto, Francisco A. M. Silva   +4 more
doaj   +1 more source

Cytokine Expression Profiling in Idiopathic Pulmonary Fibrosis: Insights From Integrative Proteomic Analysis

Canadian Respiratory Journal, Volume 2025, Issue 1, 2025.
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease with a poor prognosis and no effective pharmacological treatments. Cytokines are a class of small‐molecule proteins with diverse biological activities. Many cytokines—most notably transforming growth factor β—have been demonstrated to play an important role ...
Chenyou Shen, Wei Wang, Guirong Li, Dong Wei, Xusheng Yang, Cheng Jiang, Yating Sheng, Yuan Chen, Jingjing Xu, Shugao Ye, Jingyu Chen, Tan Jiang-Shan   +11 more
wiley   +1 more source

Tripodal BODIPY‐Tagged and Functional Molecular Probes: Synthesis, Computational Investigations and Explorations by Multiphoton Fluorescence Lifetime Imaging Microscopy

Chemistry – A European Journal, Volume 30, Issue 49, September 2, 2024.
We report on new and conjugatable tripodal compounds which open up the possibility for multiplexing with BODIPY tags for studies by confocal microscopy and 2P FLIM with structural and photochemical predictions underpinned by TD‐DFT calculations. Abstract A range of novel BODIPY derivatives with a tripodal aromatic core was synthesized and characterized
Marina Lledos, David G. Calatayud, Fernando Cortezon‐Tamarit, Haobo Ge, Charareh Pourzand, Stanley W. Botchway, Mariona Sodupe, Agustí Lledós, Ian M. Eggleston, Sofia I. Pascu   +9 more
wiley   +1 more source

Fluorine-Containing Taxoid Anticancer Agents and Their Tumor-Targeted Drug Delivery

Journal of fluorine chemistry, 2013
A long-standing problem of conventional chemotherapy is the lack of tumor-specific treatments. Traditional chemotherapy relies on the premise that rapidly proliferating cancer cells are more likely to be killed by a cytotoxic agent.
Joshua D. Seitz, Jacob G. Vineberg, Edison S. Zuniga, I. Ojima   +3 more
semanticscholar   +1 more source

Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs

ChemCatChem, Volume 16, Issue 9, May 8, 2024.
A Taxus 2‐O‐benzoyltransferase (mTBT), assisted by CoA, is used to biocatalytically deconstruct older‐generation paclitaxel precursors by removing the 2‐O‐benzoyl group from baccatin III or one of its 10‐O‐acyl analogs. mTBT then appends various non‐natural (m‐substituted)benzoyl groups, transferring them from CoA thioesters to the debenzoylated ...
Aimen Al‐Hilfi, Zhen Li, Kenneth M. Merz Jr., Irosha N. Nawarathne, Kevin D. Walker   +4 more
wiley   +1 more source

Part I. Design, synthesis and biological evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents., Part II. Development of novel taxoid-based drug conjugates and theranostic imaging agents towards tumor-targeted chemotherapy [PDF]

, 2014
Part I. Design, synthesis and biological evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents Filamenting temperature-sensitive protein Z (FtsZ), an essential cell division protein, is a promising target for the
Park, Bora
core  

Synthesis of novel taxoid analogue containing sulfur group on C-13 side-chain: 2′-deoxy-2′-epi-mercaptopaclitaxel

, 2019
Paclitaxel analogues with a thiol group in place of the hydroxyl group on the C-13 side-chain constitute an interesting avenue of research for the study of new taxoid compounds.
윤주영
core   +1 more source

Design and synthesis of a novel photoanity taxoid as a potential probe for the study of paclitaxel±microtubules interactions

, 2020
A novel and non-radioactive bifunctional photoanity probe (BPP) for the study of paclitaxel±micro-tubules interactions is designed and synthesized.
Kan Fang, Songnian Lin, Iwao Ojima, Koji Nakanishi, Masaru Hashimoto   +4 more
core  

Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models

Nanoscale Research Letters, 2011
Docetaxel (DTX) is a very important member of taxoid family. Despite several alternative delivery systems reported recently, DTX formulated by Polysorbate 80 and alcohol (Taxotere®) is still the most frequent administration in clinical practice.
Geng Hongquan, Wang Juan, Peng Xia, Song Hua, Ruan Jing, Wang Kan, Bao Chenchen, Zhang Xueqing, Cui Daxiang   +8 more
doaj