Results 61 to 70 of about 1,290 (186)

Enhancing taxane production in Corylus avellana L. cell cultures through elicitation using molybdenum oxide and iron oxide nanoparticles

Industrial Crops and Products
Taxanes are widely employed in cancer therapy for the treatment of various malignancies. Recent studies have shown that cell cultures from Corylus avellana L. could be a promising source for producing taxanes commercially.
Roghayyeh Hazrati, Nasser Zare, Rasool Asghari-Zakaria, Parisa Sheikhzadeh, Mahipal S. Shekhawat, Rupesh Kumar Singh   +5 more
doaj   +1 more source

The final acylation step in Taxol biosynthesis: Cloning of the taxoid C13-side-chain N -benzoyltransferase from Taxus

, 2002
The formation of several acyl groups and an amide group of Taxol is catalyzed by regioselective CoA thioester-dependent acyltransferases.
Rodney Croteau, Robert Long, Kevin Walker   +2 more
core   +1 more source

Design and synthesis of a novel photoanity taxoid as a potential probe for the study of paclitaxel±microtubules interactions

, 2020
A novel and non-radioactive bifunctional photoanity probe (BPP) for the study of paclitaxel±micro-tubules interactions is designed and synthesized.
Kan Fang, Songnian Lin, Iwao Ojima, Koji Nakanishi, Masaru Hashimoto   +4 more
core  

C–C Bond Cleavage of Carvone-Derived Cyclobutanols En Route to Abscisic Acid Analogs and Taxoid Natural Products [PDF]

, 2019
This dissertation describes our application of C–C bond cleavage methodology on carvone-derived cy- clobutanols to access functionalized cyclohexenones, which have been utilized toward 1) the syntheses of analogs of the plant hormone abscisic acid, and 2)
Wang, Brian S
core  

Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for ¹¹C‑Labeling

, 2018
Next-generation taxoids, such as SB-T-1214, are highly potent cytotoxic agents that exhibit remarkable efficacy against drug-resistant tumors in vivo, including those that overexpress the P-glycoprotein (Pgp) efflux pump.
Jacob G. Vineberg (4862263), Joshua D. Seitz (4862260), Tao Wang (12008), Tadashi Honda (1585384), Iwao Ojima (295240)   +4 more
core   +1 more source

Design, Synthesis and Biological Evaluation of the 3rd Generation Taxoids and Novel Taxoid-based Small Molecule Drug Conjugates (SMDCs)

, 2017
Cancer is one of the top two leading causes of death in the United States, responsible for one in six deaths worldwide. Although paclitaxel and docetaxel are still being heavily used in clinic for treatment of various cancers, the multi-drug resistance ...
Wang, Changwei
core  

Synthesis and in vitro evaluation of taxol oxetane ring D precursors

, 2010
A series of potential taxoid substrates was prepared in radiolabeled form to probe in vitro for the oxirane formation step and subsequent ring expansion step to the oxetane (ring D) presumably involved in the biosynthesis of the anticancer agent Taxol ...
Croteau, Rodney B., Kaspera, Rüdiger, Faraldos, Juan A., Ketchum, Raymond E. B., Cape, Jonathan L.   +4 more
core   +1 more source

Design, synthesis, and biological evaluation of novel taxoid-based drug conjugates and theranostic imaging agents towards tumor-targeted chemotherapy [PDF]

, 2014
Cancer remains the second leading cause of death in the United States, accounting for nearly a quarter of all deaths, and is exceeded only by heart disease.
Vineberg, Jacob G.
core  

Phase I and Pharmacokinetic Study of a New Taxoid, RPR 109881A, Given as a 1-Hour Intravenous Infusion in Patients With Advanced Solid Tumors

, 2000
PURPOSE: RPR 109881A is a new semisynthetic taxoid compound that has a similar mechanism of action to docetaxel. The purpose of this phase I study was to characterize the maximum-tolerated dose (MTD), toxicity profile, pharmacokinetic profile, and ...
Takayasu Kurata, Noboru Yamamoto, Hideyuki Wakasugi, Toshiaki Saeki, Shigemitsu Takashima, Masaki Kashimura, Tomohide Tamura, Keiichi Fujiwara, Ichinosuke Hyodo, Yasuhiro Shimada   +9 more
core   +1 more source

Design, synthesis, and biological evaluation of novel taxoid-based small-molecule theranostic PET/SPECT imaging agents and nano-scale asymmetric bow-tie dendrimer drug conjugates towards tumor-targeted chemotherapy

, 2015
Cancer remains the second leading cause of death in the United States. Traditional chemotherapy relies on highly potent cytotoxic agents, such as paclitaxel and docetaxel, to kill rapidly dividing cancer cells.
Wang, Tao
core