Results 81 to 90 of about 2,931 (217)
, 2005 14 páginas, 10 figuras, 4 tablas -- PAGS nros. 11525-11538Cyclostreptin (FR182877), a bacterial natural product, was reported to have weak paclitaxel-like activity with tubulin but antitumor activity in vivo. We used synthetic cyclostreptin in studies of
Hamel, Ernest +8 more
core +1 more source
The design, synthesis and biological evaluation of novel taxoid anticancer agents and their tumor-targeted drug conjugates [PDF]
, 2013 Cancer is the second leading cause of death in the United States and is responsible for one in eight deaths worldwide. Traditional chemotherapeutics target the processes involved in cell division and consequently produce dangerous and dose-limiting side ...
Seitz, Joshua
core
, 2016 A series of novel macrocyclic taxoids 6 and 6‘ bearing 16-, 17-, and 18-membered rings connecting the substituents at the C-2 and C-3‘ positions were designed and synthesized. The syntheses of these macrocycles 6 and 6‘ were accomplished using the highly
Songnian Lin (2435152) +6 more
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Synthesis and Biological Evaluation of Second and Third Generation of Taxoid Anticancer Agents
, 2014 Cancer is a group of diseases leading by uncontrolled cell growth, and is responsible for approximately one in four deaths in the United States. While significant advancements have been made in chemotherapy, combating drug resistant strains have remained
Wang, Xin
core
Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11C‑Labeling
, 2018 Next-generation taxoids, such as SB-T-1214, are highly potent cytotoxic agents that exhibit remarkable efficacy against drug-resistant tumors in vivo, including those that overexpress the P-glycoprotein (Pgp) efflux pump.
Jacob G. Vineberg (4862263) +4 more
core +1 more source
, 2002 The formation of several acyl groups and an amide group of Taxol is catalyzed by regioselective CoA thioester-dependent acyltransferases.
Rodney Croteau +2 more
core +1 more source
Huli yanjiuObjectiveTo evaluate the effect on chemotherapy⁃induced peripheral neurotoxicity（CIPN），hand and foot syndrome（HFS），and quality of life in breast cancer patients treated with intermittent hand and foot hypothermia at different temperatures.MethodsA total ...
LI Ran +3 more
doaj
α‑Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana
, 2017 From a CH2Cl2 extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A–F (1–6), were isolated, together with 29 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation ...
Nhan Trung Nguyen (2020468) +10 more
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Case Report: Intravitreal dexamethasone implant as adjuvant treatment for taxane-related cystoid macular edema. [PDF]
Front Ophthalmol (Lausanne), 2022 Liu X, Ding X, Lin G.
europepmc +1 more source
Isolation of taxoids from cell suspension cultures of Taxus wallichiana
, 2000 Cell suspension cultures of stem-derived callus of Taxus wallichiana in MS-F culture media were found to produce three C-14 oxygenated taxoids and one regular taxoid.
Kulshrestha, Manish +6 more
core +1 more source