Results 71 to 80 of about 2,931 (217)
Industrial Crops and ProductsTaxanes are widely employed in cancer therapy for the treatment of various malignancies. Recent studies have shown that cell cultures from Corylus avellana L. could be a promising source for producing taxanes commercially.
Roghayyeh Hazrati +5 more
doaj +1 more source
Design and synthetic approach to a taxoid analogue.
, 1998 The design and synthetic strategy towards a taxoid analogue that contains the important functional groups required for biological activity is described.
Mackintosh, Nicole Lea.
core +1 more source
, 2016 Efficient Asymmetric Syntheses of β-Lactams Bearing a Cyclopropane or an Epoxide Moiety and Their Application to the Syntheses of Novel Isoserines and ...
Songnian Lin (2435152) +1 more
core +1 more source
Dual-Functional abeo -Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-κB Activation [PDF]
, 2013 Taxchinin A, with a 11(15→1)-abeo-taxane skeleton, is a major, but inactive taxoid contained in leaves of Taxus chinensis. In our design of dual-functional antitumor abeo-taxane derivatives, two fragments from antitumor agents with different molecular ...
Goto, Masuo +7 more
core +1 more source
, 2006 Previous studies on the drug content of pelleted tubulin polymers suggest that peloruside A binds in the laulimalide site, which is distinct from the taxoid site.
Hamel, Ernest +10 more
core +1 more source
Synthesis and in vitro evaluation of taxol oxetane ring D precursors
, 2010 A series of potential taxoid substrates was prepared in radiolabeled form to probe in vitro for the oxirane formation step and subsequent ring expansion step to the oxetane (ring D) presumably involved in the biosynthesis of the anticancer agent Taxol ...
Croteau, Rodney B. +4 more
core +1 more source
, 2017 Cancer is one of the top two leading causes of death in the United States, responsible for one in six deaths worldwide. Although paclitaxel and docetaxel are still being heavily used in clinic for treatment of various cancers, the multi-drug resistance ...
Wang, Changwei
core
Rapid, Photoactivatable Turn-On Fluorescent Probes Based on an Intramolecular Photoclick Reaction
, 2016 Photoactivatable fluorescent probes are invaluable tools for the study of biological processes with high resolution in space and time. Numerous strategies have been developed in generating photoactivatable fluorescent probes, most of which rely on the ...
Zhipeng Yu (1311822) +2 more
core +1 more source
, 2016 This work describes the synthesis of a series of novel macrocyclic taxoids 3 and 3(H) designed to mimic the docetaxel solid-state (“nonpolar”) conformation.
Françoise Guéritte (2639503) +6 more
core +1 more source
Design, synthesis, and biological evaluation of novel taxoid-based drug conjugates and theranostic imaging agents towards tumor-targeted chemotherapy [PDF]
, 2014 Cancer remains the second leading cause of death in the United States, accounting for nearly a quarter of all deaths, and is exceeded only by heart disease.
Vineberg, Jacob G.
core