Results 51 to 60 of about 1,290 (186)

Antisense-induced suppression of taxoid 14β-hydroxylase gene expression in transgenic Taxus × media cells

, 2011
The enzyme taxoid 14β-hydroxylase (14OH) directs a side-route of taxol pathway to 14β-hydroxy taxoids. Suppression of this side-route could increase the production of taxol.
Li, Feng-Lan, Qui, De-You, Dai, Jun-Gui, Hoffman, Angela, Ma, Xiao-Jun   +4 more
core   +1 more source

Cytokine Expression Profiling in Idiopathic Pulmonary Fibrosis: Insights From Integrative Proteomic Analysis

Canadian Respiratory Journal, Volume 2025, Issue 1, 2025.
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease with a poor prognosis and no effective pharmacological treatments. Cytokines are a class of small‐molecule proteins with diverse biological activities. Many cytokines—most notably transforming growth factor β—have been demonstrated to play an important role ...
Chenyou Shen, Wei Wang, Guirong Li, Dong Wei, Xusheng Yang, Cheng Jiang, Yating Sheng, Yuan Chen, Jingjing Xu, Shugao Ye, Jingyu Chen, Tan Jiang-Shan   +11 more
wiley   +1 more source

Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly.

, 2006
Previous studies on the drug content of pelleted tubulin polymers suggest that peloruside A binds in the laulimalide site, which is distinct from the taxoid site.
Hamel, Ernest, Nicolaou, K C, Paterson, Ian, Miller, John H, Northcote, Peter T, Curran, Dennis P, Ghosh, Arun K, Jung, M Katherine, Cushman, Mark, Day, Billy W, Sorensen, Erik J   +10 more
core   +1 more source

Tripodal BODIPY‐Tagged and Functional Molecular Probes: Synthesis, Computational Investigations and Explorations by Multiphoton Fluorescence Lifetime Imaging Microscopy

Chemistry – A European Journal, Volume 30, Issue 49, September 2, 2024.
We report on new and conjugatable tripodal compounds which open up the possibility for multiplexing with BODIPY tags for studies by confocal microscopy and 2P FLIM with structural and photochemical predictions underpinned by TD‐DFT calculations. Abstract A range of novel BODIPY derivatives with a tripodal aromatic core was synthesized and characterized
Marina Lledos, David G. Calatayud, Fernando Cortezon‐Tamarit, Haobo Ge, Charareh Pourzand, Stanley W. Botchway, Mariona Sodupe, Agustí Lledós, Ian M. Eggleston, Sofia I. Pascu   +9 more
wiley   +1 more source

Cyclostreptin (FR182877), an Antitumour Tubulin-Polymerizing Agent Deficient in Enhancing Tubulin Assembly Despite Its High Affinity for the Taxoid Site

, 2005
14 páginas, 10 figuras, 4 tablas -- PAGS nros. 11525-11538Cyclostreptin (FR182877), a bacterial natural product, was reported to have weak paclitaxel-like activity with tubulin but antitumor activity in vivo. We used synthetic cyclostreptin in studies of
Hamel, Ernest, Gussio, Rick, Martínez Buey, Rubén, Sorensen, Erik J., Díaz, José Fernando, Giannakakou, Paraskevi, Vanderwal, Christopher D., Edler, Michael C., Marcus, Adam I.   +8 more
core   +1 more source

Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs

ChemCatChem, Volume 16, Issue 9, May 8, 2024.
A Taxus 2‐O‐benzoyltransferase (mTBT), assisted by CoA, is used to biocatalytically deconstruct older‐generation paclitaxel precursors by removing the 2‐O‐benzoyl group from baccatin III or one of its 10‐O‐acyl analogs. mTBT then appends various non‐natural (m‐substituted)benzoyl groups, transferring them from CoA thioesters to the debenzoylated ...
Aimen Al‐Hilfi, Zhen Li, Kenneth M. Merz Jr., Irosha N. Nawarathne, Kevin D. Walker   +4 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid–Camptothecin Combination Chemotherapy

, 2015
Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two warheads, self-immolative disulfide linkers for drug release, biotin as the tumor-targeting moiety ...
Jacob G. Vineberg (1326264), Anushree Kamath (1326267), Ying-Jen Chen (641939), Joshua D. Seitz (1326261), Edison S. Zuniga (462561), Iwao Ojima (295240)   +5 more
core   +1 more source

Improved Biochemical Strategies for Targeted Delivery of Taxoids [PDF]

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
openaire   +2 more sources

Synthesis of novel taxoid analogue containing sulfur group on C-13 side-chain: 2′-deoxy-2′-epi-mercaptopaclitaxel

, 2019
Paclitaxel analogues with a thiol group in place of the hydroxyl group on the C-13 side-chain constitute an interesting avenue of research for the study of new taxoid compounds.
윤주영
core   +1 more source

Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models

Nanoscale Research Letters, 2011
Docetaxel (DTX) is a very important member of taxoid family. Despite several alternative delivery systems reported recently, DTX formulated by Polysorbate 80 and alcohol (Taxotere®) is still the most frequent administration in clinical practice.
Geng Hongquan, Wang Juan, Peng Xia, Song Hua, Ruan Jing, Wang Kan, Bao Chenchen, Zhang Xueqing, Cui Daxiang   +8 more
doaj