Results 51 to 60 of about 2,931 (217)
Bioorganic & Medicinal Chemistry, 2015 The folate receptor (FR) has been widely recognized as an excellent target for the tumor-selective delivery of cytotoxic agents, and four folate-drug conjugates have entered clinical evaluations for the treatment of solid tumors to date. However, most of
Joshua D. Seitz +5 more
semanticscholar +1 more source
Pacific Blue Derivatives of Paclitaxel as Fluorescent Probes of OATP1B‐Type Transporters
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Paclitaxel (Taxol) is a widely used anticancer agent that undergoes extensive hepatic metabolism and that causes a debilitating, dose‐limiting peripheral neurotoxicity. We previously reported that the uptake of paclitaxel in hepatocytes and dorsal root ganglion neurons, the site of injury within the nervous system, is mediated by the organic ...
Mahesh R. Nepal +11 more
wiley +1 more source
Alkyne zip reaction in the synthesis of a taxoid C-ring
, 2000 International audienceHydrazone 30, precursor of a taxoid C-ring, was synthesized in 7 steps from commercial 2-methyl-1,3-cyclohexanedione. An enantioselective approach to 30 was also investigated, using a reduction of diketone 11 with bakers' yeast to ...
Lallemand, Jean-Yves +4 more
core +1 more source
Design, Synthesis and Biological Evaluation of Theranostic Vitamin-Linker-Taxoid Conjugates
Journal of Medicinal Chemistry, 2015 Novel tumor-targeting theranostic conjugates 1 and 2, bearing either a fluorine-labeled prosthetic as a potential 18F-PET radiotracer (1) or a fluorescence-probe (2) for internalization studies in vitro, were designed and synthesized.
Jacob G. Vineberg +3 more
semanticscholar +1 more source
Food Science &Nutrition, Volume 13, Issue 11, November 2025.Taxus wallichaina extracts and its biosynthesized silver nanoparticles shows promising anticancer and anti‐inflammatory properties. ABSTRACT This study investigates the green synthesis of silver nanoparticles (AgNPs) using Taxus wallichiana Zucc. and evaluates their pharmacological potential.
Fazli Hadi +11 more
wiley +1 more source
, 2015 Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two warheads, self-immolative disulfide linkers for drug release, biotin as the tumor-targeting moiety ...
Jacob G. Vineberg (1326264) +5 more
core +1 more source
Journal of Medicinal Chemistry, 2014 Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two warheads, self-immolative disulfide linkers for drug release, biotin as the tumor-targeting moiety ...
Jacob G. Vineberg +5 more
semanticscholar +1 more source
Taxuspinanane G from the Aerial Parts of Taxus baccata L. Growing in Iran
Journal of Medicinal Plants, 2008 Background: The discovery of paclitaxel (Taxol®) as a potent anticancer drug from Taxus brevifolia has encouraged several groups all over the world to conduct research work on other Taxus species, in order to isolate potentially more effective paclitaxel
MR Verdian - Rizi +4 more
doaj
Patient‐derived xenograft models in pan‐cancer: From bench to clinic
Interdisciplinary Medicine, Volume 3, Issue 5, September 2025.Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li +5 more
wiley +1 more source