Results 41 to 50 of about 3,403 (164)

Adjuvant systemic treatment in luminal breast cancer — what else apart from hormone therapy?

Oncology in Clinical Practice
The luminal subtype [hormone receptor (HR) expression and absence of HER2 overexpression] occurs in more than 70% of patients with early breast cancer.
Sylwia Dębska-Szmich, Piotr Potemski
doaj   +1 more source

Reactions of a-4(20)-epoxy-5-O-mesyltriacetyltaxicine I induced by BF3·Et2O/Bu4NBr [PDF]

Journal of the Serbian Chemical Society, 2006
The reaction of a-(20)-epoxy-5-O-mesyltriacetyltaxicine I (2) with BF3·Et2O/Bu4NBr can give rise to 4 different products. Each of these products can be obtained selectively, under the appropriate reaction conditions.
ZORANA FERJANCIC, RADOMIR MATOVIC, ZIVORAD CEKOVIC, RADOMIR N. SAICIC   +3 more
doaj  

Fluorescent Taxoid Probes for Microtubule Research

, 2010
The use of the antitumor drug taxol as an experimental microtubule-stabilizing agent is widespread. Fluorescent taxol conjugates, although less employed, are very useful tools for several purposes in microtubule research. These include easily visualizing microtubule cytoskeletons in a variety of cells as well as in vitro assembled microtubules ...
Barasoain, Isabel, Díaz, José Fernando, Andreu, José Manuel   +2 more
openaire   +3 more sources

Taxezopidine-G from needles and young stems of Taxus baccata L. growing in Iran

Journal of Medicinal Plants, 2005
Background: Taxus species are important due to their content of Taxol, baccatin III, 10- deacetyl baccatin and other taxoids suitable to change to active pharmaceutical ingredients, which are used as anti-neoplastic agents.
M Pirali-Hamedani, Verdian Rizi MR, SH Rezazadeh, R Dowlatabadi, A Hadjiakhoondi, M Amini, D Yazdani   +6 more
doaj  

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, Volume 3, Issue 5, September 2025.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Taxane Diterpenoids from Taxus baccata L. Growing in Iran

Journal of Medicinal Plants, 2009
Background: There are eight Taxus species and two hybrids in the world and Taxus baccata L. (European yew) is the single representative in Iran. Until now, a large number of taxoids possessing different skeleton systems, as well as lignans, flavonoids ...
A Hadjiakhoondi, M Pirali - Hamedani, MR Verdian-Rizi, Sh Rezazadeh   +3 more
doaj  

Cytokine Expression Profiling in Idiopathic Pulmonary Fibrosis: Insights From Integrative Proteomic Analysis

Canadian Respiratory Journal, Volume 2025, Issue 1, 2025.
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease with a poor prognosis and no effective pharmacological treatments. Cytokines are a class of small‐molecule proteins with diverse biological activities. Many cytokines—most notably transforming growth factor β—have been demonstrated to play an important role ...
Chenyou Shen, Wei Wang, Guirong Li, Dong Wei, Xusheng Yang, Cheng Jiang, Yating Sheng, Yuan Chen, Jingjing Xu, Shugao Ye, Jingyu Chen, Tan Jiang-Shan   +11 more
wiley   +1 more source

Tripodal BODIPY‐Tagged and Functional Molecular Probes: Synthesis, Computational Investigations and Explorations by Multiphoton Fluorescence Lifetime Imaging Microscopy

Chemistry – A European Journal, Volume 30, Issue 49, September 2, 2024.
We report on new and conjugatable tripodal compounds which open up the possibility for multiplexing with BODIPY tags for studies by confocal microscopy and 2P FLIM with structural and photochemical predictions underpinned by TD‐DFT calculations. Abstract A range of novel BODIPY derivatives with a tripodal aromatic core was synthesized and characterized
Marina Lledos, David G. Calatayud, Fernando Cortezon‐Tamarit, Haobo Ge, Charareh Pourzand, Stanley W. Botchway, Mariona Sodupe, Agustí Lledós, Ian M. Eggleston, Sofia I. Pascu   +9 more
wiley   +1 more source

Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs

ChemCatChem, Volume 16, Issue 9, May 8, 2024.
A Taxus 2‐O‐benzoyltransferase (mTBT), assisted by CoA, is used to biocatalytically deconstruct older‐generation paclitaxel precursors by removing the 2‐O‐benzoyl group from baccatin III or one of its 10‐O‐acyl analogs. mTBT then appends various non‐natural (m‐substituted)benzoyl groups, transferring them from CoA thioesters to the debenzoylated ...
Aimen Al‐Hilfi, Zhen Li, Kenneth M. Merz Jr., Irosha N. Nawarathne, Kevin D. Walker   +4 more
wiley   +1 more source

Hyperglycemia induced by systemic therapy in patients with breast cancer — a retrospective single-center analysis

Oncology in Clinical Practice
INTRODUCTION: Glucose metabolism disorders are associated with an increased risk of breast cancer (BC), which is the most common cancer in women. The association between metabolic disorders and BC is well established.
Joanna Kujawska, Olga Milbrandt, Wojciech Czaiński, Agnieszka M. Mariowska, Rodryg Ramlau   +4 more
doaj   +1 more source