Results 61 to 70 of about 4,048 (209)

Taxoids from Taxus chinensis

, 2016
Two new taxoids, 13,15-epoxy-13-epi-taxayunnasin A (1) and taxchinin N (2), were isolated from the leaves and stems of Taxus chinensis. Compound 2 is the first taxoid to be reported with an α,β-unsaturated lactone at C-4, C-5, C-20, and C-2.
Yu Zhao (104852), Gang Xu (219455), Fu-Sheng Wang (300650), Li-Yan Peng (1647883), Qi-Tai Zheng (2378572), Xiao-Li Li (43119), Yang Lu (59885), Xiao-Xin Luo (2514049), Li Wu (120770), Qin-Shi Zhao (1647877)   +9 more
core   +1 more source

Hyperglycemia induced by systemic therapy in patients with breast cancer — a retrospective single-center analysis

Oncology in Clinical Practice
INTRODUCTION: Glucose metabolism disorders are associated with an increased risk of breast cancer (BC), which is the most common cancer in women. The association between metabolic disorders and BC is well established.
Joanna Kujawska, Olga Milbrandt, Wojciech Czaiński, Agnieszka M. Mariowska, Rodryg Ramlau   +4 more
doaj   +1 more source

Tripodal BODIPY‐Tagged and Functional Molecular Probes: Synthesis, Computational Investigations and Explorations by Multiphoton Fluorescence Lifetime Imaging Microscopy

Chemistry – A European Journal, Volume 30, Issue 49, September 2, 2024.
We report on new and conjugatable tripodal compounds which open up the possibility for multiplexing with BODIPY tags for studies by confocal microscopy and 2P FLIM with structural and photochemical predictions underpinned by TD‐DFT calculations. Abstract A range of novel BODIPY derivatives with a tripodal aromatic core was synthesized and characterized
Marina Lledos, David G. Calatayud, Fernando Cortezon‐Tamarit, Haobo Ge, Charareh Pourzand, Stanley W. Botchway, Mariona Sodupe, Agustí Lledós, Ian M. Eggleston, Sofia I. Pascu   +9 more
wiley   +1 more source

Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs

ChemCatChem, Volume 16, Issue 9, May 8, 2024.
A Taxus 2‐O‐benzoyltransferase (mTBT), assisted by CoA, is used to biocatalytically deconstruct older‐generation paclitaxel precursors by removing the 2‐O‐benzoyl group from baccatin III or one of its 10‐O‐acyl analogs. mTBT then appends various non‐natural (m‐substituted)benzoyl groups, transferring them from CoA thioesters to the debenzoylated ...
Aimen Al‐Hilfi, Zhen Li, Kenneth M. Merz Jr., Irosha N. Nawarathne, Kevin D. Walker   +4 more
wiley   +1 more source

Synthesis and Biological Evaluation of 2‘-Methyl Taxoids Derived from Baccatin III and 14β-OH-Baccatin III 1,14-Carbonate

, 2016
A series of 2‘-methyl taxoids were synthesized and essayed for growth inhibition experiments conducted in human ovarian cancer cell line A2780wt and its counterparts A2780cis, A2780tax, and A2780adr, resistant to cisplatin, paclitaxel, and doxorubicin ...
Ralph J. Bernacki (2402203), Carlo Bertucci (1703254), Arturo Battaglia (2390134), Antonella Riva (1541560), Andrea Guerrini (411050), Gabriele Fontana (2254297), Samanta Cimitan (2731375), Cristiano Ferlini (255998), Ezio Bombardelli (366389)   +8 more
core   +1 more source

Three Decades of Taxanes: Exploring the Next Frontier

Scientia Pharmaceutica
Taxanes, such as paclitaxel and docetaxel, are microtubule-stabilizing agents widely used in oncology, either as monotherapy or in combination regimens.
Rita I. L. Catarino, Maria Fernanda C. Leal, Adriana M. Pimenta, Maria Renata S. Souto, Francisco A. M. Silva   +4 more
doaj   +1 more source

The interaction between taxoids and serine/threonine protein phosphatase activities during taxan-induced apoptosis of HL 60 leukemic cells

, 2008
Paclitaxel and docetaxel (taxoids) are chemotherapy agents whose mode of action is through an effect on cellular microtubules. Several studies have investigated their potential in the treatment of myeloid malignancies.
Aydin H.H., Celik H.A., Sahin F., Oktem G., Saydam, G.., Omay S.B., Aydin, Hakan Hikmet, SAYDAM, GÜRAY, Celik, Handan Ak, Omay, Serdar Bedii, ŞAHİN, FAHRİ, ÖKTEM, GÜLPERİ   +11 more
core   +1 more source

Production of two intermediate taxoids, 2-hydroxy- 5α,10β-diacetoxytaxadiene and 2-hydroxy-5α,10β,14β- triacetoxytaxadiene, from Taxus chinensis cell culture [PDF]

, 2016
The production of taxuyunnanine C (Tc) (2α,5α,10β,14β-tetraacetoxytaxa-4(20),11(12)-diene) was significantly enhanced when Taxus chinensis cell cultures were treated with methyl jasmonate (MJA) or 2,3-dihydroxypropyl jasmonate (DHPJA), a newly ...
Xiao, Hong-Bin, Yue, Xiang-Guo, Zhang, Wei, Gao, Ming-Bo   +3 more
core   +1 more source

Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: Preparation, in vitro and in vivo evaluation [PDF]

, 2015
The clinically and commercially successful taxanes, paclitaxel and docetaxel suffer from two major drawbacks, namely their very low aqueous solubility and the risk of developing resistance.
He, Zhijian, Schulz, Anita, Jordan, Rainer, Seitz, Joshua, Darr, David B., Ojima, Iwao, Wan, Xiaoming, Bludau, Herdis, Alakhova, Daria Y., Perou, Charles M., Kabanov, Alexander V., Luxenhofer, Robert   +11 more
core   +1 more source

Two new taxoids, 2,14-deacetyltaxuyunnanine C and 2-deacetyltaxuyunnanine C from Taxus chinensis cell culture

, 2008
The taxuyunnanine C (Tc) was greatly enhanced when Taxus chinensis cell cultures were elicited by methyl jasmonate or 2,3-dihydroxypropyl jasmonate (DHPJA), a newly synthesized jasmonate analog in combination with in situ absorption.
张卫, 肖红斌, 岳向国, 高明波
core