Results 81 to 90 of about 3,991 (207)

PECULIARITIES OF SECONDARY METABOLITES BIOSYNTHESIS IN PLANT CELL CULTURES

International Journal of Secondary Metabolite, 2014
metabolites formation in plant cell cultures of Panax spp., (ginsenosides); Dioscorea deltoidea (steroid glycosides); Ajuga reptans, Serratula coronata, Rhaponticum carthamoides (ecdisteroids); Polyscias spp., (triterpene glycosides), Taxus spp. (taxoids)
A.M. NOSOV
doaj   +2 more sources

Production of taxoids with biological activity by plants and callus culture from selected Taxus genotypes

, 2002
Twenty seven different yew trees belonging to various genotypes and hybrids have been screened for their capacity to produce significant amounts of taxoids provided with biological activity in the tubulin test.
Meyer, M., Hocquemiller, R., Parc, G., Landré, P., Canaguier, A., Chriqui, D.   +5 more
core   +1 more source

A Meta-analysis of Platinum Plus Taxanes Regimen on Treating Advanced Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2009
Background and objective The platinum-based plus a third-generation agent doublet chemotherapy regimen has been recommended as the standard first-line chemotherapy for advanced NSCLC by ASCO and NCCN.
Ning ZHU, Jian HE, Siwei ZHANG, Xiaodong CHEN   +3 more
doaj  

New Efficient Construction of the ABC Core of the Taxoids via a Sequence of Consecutive Cobalt(I)-Mediated [2 + 2 + 2] and [4 + 2] Cyclizations

, 2016
A new and efficient sequence of two consecutive cyclizations, a cobalt(I)-mediated [2 + 2 + 2] cyclotrimerization and a Diels−Alder reaction, is proposed to allow the formation of the ABC core of the taxoids in 65% overall yield, starting from an acyclic
Marc Petit (1470346), Corinne Aubert (511920), Max Malacria (1737190), Gaëlle Chouraqui (2718955), Phannarath Phansavath (1652164)   +4 more
core   +1 more source

Macromolecular accessibility of fluorescent taxoids bound at a paclitaxel binding site in the microtubule surface

, 2013
10 p.-8 fig.The macromolecular accessibility of the paclitaxel binding site in microtubules has been investigated using a fluorescent taxoid and antibodies against fluorescein, which cannot diffuse into the microtubule lumen.
Souto, André A., Díaz, José Fernando, Amat-Guerri, Francisco, Andreu, José Manuel, Barasoain, Isabel   +4 more
core   +1 more source

Taxuspinanane G from the Aerial Parts of Taxus baccata L. Growing in Iran

Journal of Medicinal Plants, 2008
Background: The discovery of paclitaxel (Taxol®) as a potent anticancer drug from Taxus brevifolia has encouraged several groups all over the world to conduct research work on other Taxus species, in order to isolate potentially more effective paclitaxel
MR Verdian - Rizi, A Hadjiakhoondi, Sh Rezazadeh, M Khanavi, M Pirali - Hamedani   +4 more
doaj  

Simultaneous Identification and Determination of Major Taxoids from Extracts of Taxus chinensis Cell Cultures

, 2007
Liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/ MS) and high-performance liquid chromatography (HPLC) methods have been used to identify and quantify the major taxoids from extracts of Taxus chinensis cell cultures ...
Li Q Li, Fu Xiang, Chun F Zhao, Long J Yu   +3 more
core  

Transcriptome and comparative chloroplast genome analysis of Taxus yunnanensis individuals with high and low paclitaxel yield

Heliyon
Paclitaxel is a potent anti-cancer drug that is mainly produced through semi-synthesis, which still requires plant materials as precursors. The content of paclitaxel and 10-deacetyl baccatin III (10-DAB) in Taxus yunnanensis has been found to differ from
Dong Wang, Jiansheng Wei, Xiaolong Yuan, Zhonghua Chen, Lei Wang, Yunfen Geng, Jinfeng Zhang, Yi Wang   +7 more
doaj   +1 more source

Structural features of two taxoids from Taxus baccata L. growing in Turkey

, 2001
As a part of our ongoing research of the taxane-type constituents from T. baccata L. (Taxaceae) recorded in the Flora of Turkey, 2 alpha, 5 alpha, 10 beta -triacetoxy-14 beta-(2-methyl)-butryloxy-4(20),11-taxadiene (I) and taxusin (II) were isolated from
S. İde, N. Erdemoğlu, Sener, B, B. Şener, Erdemoglu, N, Ide, SEMRA   +5 more
core   +1 more source

Synthesis of C2−C3‘N-Linked Macrocyclic Taxoids. Novel Docetaxel Analogues with High Tubulin Activity

, 2016
Novel C2−C3‘N-linked macrocyclic taxoids 4 bearing an aromatic ring at position C2 were synthesized. These compounds, tethered between N3‘ and the C2-aromatic ring at the ortho, meta, or para position, were constructed by ring-closing metathesis.
Françoise Guéritte (2639503), Daniel Guénard (2639506), Olivier Querolle (2015872), Joëlle Dubois (475088), Fanny Roussi (1502851), Sylviane Thoret (475087)   +5 more
core   +1 more source