Results 71 to 80 of about 3,991 (207)

Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: Preparation, in vitro and in vivo evaluation [PDF]

, 2015
The clinically and commercially successful taxanes, paclitaxel and docetaxel suffer from two major drawbacks, namely their very low aqueous solubility and the risk of developing resistance.
He, Zhijian, Schulz, Anita, Jordan, Rainer, Seitz, Joshua, Darr, David B., Ojima, Iwao, Wan, Xiaoming, Bludau, Herdis, Alakhova, Daria Y., Perou, Charles M., Kabanov, Alexander V., Luxenhofer, Robert   +11 more
core   +1 more source

Efforts towards Development of New Generation Taxoids: SAR Study, Combination Treatment, and Gold Nanoparticle Drug Delivery System

, 2017
According to the National Cancer Institute, the number of people living with cancer is expected to rise to 19 million by 2024. While significant advancements have been made in chemotherapy, combating drug resistance and cancer stem cells have remained a ...
Wang, Xin
core   +1 more source

Cost-effectiveness analysis of the introduction of S-1 therapy for first-line metastatic breast cancer treatment in Japan: results from the randomized phase III SELECT BC trial

BMC Cancer, 2017
Background This study evaluated the cost-effectiveness of replacing standard intravenous therapy (taxane) with oral S-1 therapy for first-line metastatic breast cancer treatment.
Takeru Shiroiwa, Takashi Fukuda, Kojiro Shimozuma, Mitsuko Mouri, Yasuhiro Hagiwara, Takuya Kawahara, Shozo Ohsumi, Yasuo Hozumi, Yoshiaki Sagara, Yasuo Ohashi, Hirofumi Mukai   +10 more
doaj   +1 more source

Survival-related profile, pathways, and transcription factors in ovarian cancer.

PLoS Medicine, 2009
BackgroundOvarian cancer has a poor prognosis due to advanced stage at presentation and either intrinsic or acquired resistance to classic cytotoxic drugs such as platinum and taxoids.
Anne P G Crijns, Rudolf S N Fehrmann, Steven de Jong, Frans Gerbens, Gert Jan Meersma, Harry G Klip, Harry Hollema, Robert M W Hofstra, Gerard J te Meerman, Elisabeth G E de Vries, Ate G J van der Zee   +10 more
doaj   +1 more source

Synthesis and Biological Evaluation of Methoxylated Analogs of the Newer Generation Taxoids IDN5109 and IDN5390

, 2005
Starting from 10-deacetylbaccatin 111 (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized.
BOMBARDELLI E., BARBONI, L., BARBONI, Luciano, BALLINI, Roberto, E., APPENDINO G., GIARLO, Guido, FONTANA G., G. , BOMBARDELLI, G. , FONTANA, BALLINI, R., GIARLO, G., APPENDINO, Giovanni Battista   +12 more
core   +1 more source

Natural Based Anticancer Drugs and Their Worthiness

Hospital Practices and Research, 2017
With the prevalence of every type of cancer increasing globally, the inability to treat and the severe side effects caused by chemotherapy and radiotherapy are some of the biggest problems facing cancer patients and their physicians.1 Many herbal ...
Kamran Hajinabi
doaj   +1 more source

Efeitos colaterais cutâneos de quimioterapia com taxanos: O ponto de vista do dermatologista Cutaneous adverse reactions to chemotherapy with taxanes: The dermatologist's point of view

Anais Brasileiros de Dermatologia, 2011
Taxanos são drogas quimioterápicas cada vez mais utilizadas no tratamento adjuvante de um grande número de cânceres, principalmente câncer de mama e de pulmão.
Aline Donati, Luiz Guilherme Martins Castro   +1 more
doaj   +1 more source

The interaction between taxoids and serine/threonine protein phosphatase activities during taxan-induced apoptosis of HL 60 leukemic cells

, 2008
Paclitaxel and docetaxel (taxoids) are chemotherapy agents whose mode of action is through an effect on cellular microtubules. Several studies have investigated their potential in the treatment of myeloid malignancies.
Aydin H.H., Celik H.A., Sahin F., Oktem G., Saydam, G.., Omay S.B.   +5 more
core   +1 more source

Production of Biologically Active Taxoids by a Callus Culture of Taxus cuspidata

, 2016
Ten known taxoids, paclitaxel, 7-epi-taxol, taxol C, baccatin VI, taxayuntin C, taxuyunnanine C and its analogues (2−5), and yunnanxane (6), and an abietane, taxamairin A, were produced in the callus culture of Taxus cuspidata cultivated on a modified ...
Katutoshi Hirose (2685235), Mutumi Kitabatake (2685244), Kazuki Toyoizumi (2726482), Junichi Sakai (77403), Liwei Fu (2726485), Masayoshi Ando (2685238), Jungui Dai (610572), Takao Yamori (704541), Akihiro Tomida (133017), Jiao Bai (737971), Shujun Zhang (314599), Takashi Tsuruo (2367658)   +11 more
core   +1 more source

Synthesis and biological evaluation of 2 '-methyl taxoids derived from baccatin III and 14 beta-OH-baccatin III 1,14-carbonate

, 2003
A series of 2-methyl taxoids were synthesized and essayed for growth inhibition experiments conducted in human ovarian cancer cell line A2780wt and its counterparts A2780cis, A2780tax, and A2780adr, resistant to cisplatin, paclitaxel, and doxorubicin ...
Bernacki RJ, Ferlini C, Battaglia A, Bombardelli E, Cimitan S, Guerrini A, Bertucci C, Fontana G, Riva A   +8 more
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