Results 91 to 100 of about 3,991 (207)

Production of two intermediate taxoids, 2-hydroxy-5 alpha, 10 beta-diacetoxytaxadiene and 2-hydroxy-5 alpha, 10 beta, 14 beta-triacetoxytaxadiene, from Taxus chinensis cell culture

open access: yes, 2010
The production of taxuyunnanine C (Tc) (2 alpha, 5 alpha, 10 beta, 14 beta-tetraacetoxytaxa-4(20), 11(12)-diene) was significantly enhanced when Taxus chinensis cell cultures were treated with methyl jasmonate (MJA) or 2,3-dihydroxypropyl jasmonate ...
Xiao, Hong-Bin   +3 more
core  

Design, Synthesis and Biological Evaluation of the 3rd Generation Taxoids and Novel Taxoid-based Small Molecule Drug Conjugates (SMDCs)

open access: yes, 2017
Cancer is one of the top two leading causes of death in the United States, responsible for one in six deaths worldwide. Although paclitaxel and docetaxel are still being heavily used in clinic for treatment of various cancers, the multi-drug resistance ...
Wang, Changwei
core   +1 more source

Use of endophytic fungi in the Taxol anticancer drug production

open access: yesBiotecnología Vegetal, 2014
Taxol is a drug used in the chemotherapy of breast, lung, ovarian, prostate, liver cancers, and in the treatment of rheumatoid arthritis. Taxol is obtained from Taxus spp. trees. It is found in low concentrations in the bark, needles and roots.
Hebert Jair Barrales-Cureño   +1 more
doaj  

No auxiliary, no byproduct strategy for water-soluble prodrugs of taxoids: Scope and limitation of O-N intramolecular acyl and acyloxy migration reactions

open access: yes, 2005
Since numerous new taxoids active against multidrug resistant (MDR) tumors have been developed and their poor water-solubility is a very real problem in intravenous administration, we have designed and synthesized a series of novel water-soluble taxoid ...
Noguchi, Mayo   +7 more
core   +1 more source

CR4 cells are highly resistant to treatment with cytotoxic drugs (comparative cytotoxicity of paclitaxel and new-generation taxoids against CR4 cells).

open access: yes, 2014
Commonly used Paclitaxel (Taxol) in doses lower than 10 µM is not effective against CR4 cells and often increases their proliferation. In contrast, several new-generation taxoids induce dose-dependent inhibition of proliferation of these potent tumor ...
Roberto Bergamaschi (25663)   +11 more
core   +1 more source

1-Deoxypaclitaxel and abeo-Taxoids from the Seeds of Taxus mairei

open access: yes, 2016
A new paclitaxel derivative and two new 2(3→20)-abeo-taxoids were isolated from a methanol extract of the seeds of Taxus mairei, and their structures were established as 1-deoxypaclitaxel (1), 7β,10β-diacetoxy-2α,5α,13α-trihydroxy-2(3→20)-abeo-taxa-4(20),
Xiao-Tang Si (2649670)   +5 more
core   +1 more source

PECULIARITIES OF SECONDARY METABOLITES BIOSYNTHESIS IN PLANT CELL CULTURES

open access: yesInternational Journal of Secondary Metabolite, 2016
Plant cell culture is traditionally viewed as a unique artificially created biological system represented a heterogenous population of dedifferentiated cells.
A.M. NOSOV
doaj  

Tasumatrols P-T, Five New Taxoids from Taxus Sumatrana

open access: yes, 2008
The phytochemical investigation of the more polar fractions from the leaves and twigs of Taxus sumatrana (Taxaceae) afforded five new taxane diterpene esters, tasumatrols P-T ( 1-5) possessing an 11(15 -> 1),11(10 - > 9)-diabeotaxane skeleton.
沈雅敬;簡慶德;郭曜豪;周昌弘   +1 more
core  

Tri- and Bicyclic Taxoids from the Taiwanese Yew Taxus Sumatrana

open access: yes, 2010
Five new taxoids, including a new 2(3 -> 20)-abeo-taxane with a 6/10/6- membered ring system and four 3,8-seco-taxanes having a 6/12-membered ring system, were isolated from an acetone extract of the leaves and twigs of the Taiwanese yew (Taxus sumatrana,
LUH, LON-JE;LIAW, CHIA-CHING;CHEN, CHEN -TUNG;LIN, YUN-SHENG;CHIEN, CHING-TE;SHEN, YA-CHING   +1 more
core  

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