Results 101 to 110 of about 3,403 (164)

Structured Expert Elicitation of Long-Term Survival in Non-small Cell Lung Cancer: A Case Study Applying Guidance from NICE Technical Support Document 26. [PDF]

Appl Health Econ Health Policy
Forsyth JE, Achra M, Espinar JB, Hochmair M, Liepa AM, Lenox-Smith A, Puri T, Rajesh R, Sonksen MD, Summers Y, van der Wekken AJ, Jen MH, Ren S.   +12 more
europepmc   +1 more source

Chromosomal instability in circulating tumor cells and cabazitaxel resistance in metastatic castration-resistant prostate cancer. [PDF]

JCI Insight
Longoria O, Rekowski J, Gupta S, Beije N, Pantel K, Efstathiou E, Sternberg C, Castellano D, Fizazi K, Tombal B, Sharp A, Sartor O, Macé S, Geffriaud-Ricouard C, Wenstrup R, de Wit R, de Bono J.   +16 more
europepmc   +1 more source

A PSMA-targeted dextran-based conjugate eradicates PSMA-overexpressing prostate tumors while abolishing cabazitaxel toxicity. [PDF]

Theranostics
Yang L, Liu T, Huo M, Jia W, Chen Y, Ge M, Pan Y, Shi J, Li X, Wang S, Shi Y.   +10 more
europepmc   +1 more source

A topical nociceutical formulation ameliorates chemotherapy-induced peripheral neuropathy: a pilot randomized clinical study. [PDF]

Clin Transl Oncol
Servitja S, Castro-Henriques M, Álvarez-Busto I, Díez-Franco C, Medina-Castillo A, Algarra-García MA, López-Miranda E, Lario-Martínez M, Luengo-Alcázar MI, Borregón M, Davó A, Gasull-Delgado A, Roque-García S, Gonzaga-López A, Poveda-Ferriols JM, Pascal S, Mitroi-Marinescu AM, García-Escolano M, Fernández-Carvajal A, Ferrándiz-Huertas C, Ferrer-Montiel A.   +20 more
europepmc   +1 more source

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The taxoids: paclitaxel and docetaxel

Lancet, The, 1994
K Gelmon
exaly   +3 more sources

Taxoid metabolism: Taxoid 14β-hydroxylase is a cytochrome P450-dependent monooxygenase

Archives of Biochemistry and Biophysics, 2003
The production of the anticancer drug Taxol in Taxus (yew) cell cultures is often accompanied by the formation of side-route polyoxygenated taxoid metabolites bearing a 14beta-hydroxyl group. The recent acquisition of several new semisynthetic taxoid intermediates enabled the screening of a family of Taxus cytochrome P450 cDNA clones for the 14beta ...
Stefan, Jennewein, Christopher D, Rithner, Robert M, Williams, Rodney, Croteau   +3 more
openaire   +2 more sources

The Taxoids

Drugs, 1998
Paclitaxel and docetaxel are 2 compounds from the new taxoid class of anti-cancer agents. Both drugs are very similar in preclinical activity, mechanism of action and spectrum of clinical activity. Some subtle differences in the intracellular retention of docetaxel may account for its lack of schedule-related myelosuppression and greater potency, and ...
Eisenhauer, Elizabeth A., Vermorken, Jan B.   +1 more
openaire   +3 more sources

Taxoids from the needles of the Canadian yew

Phytochemistry, 2000
Systematic characterization of the taxoids in the needles of Taxus canadensis led to the discovery of seven taxanes along with three known congeners. Their structures were rigorously established by spectroscopic methods as 15-benzoyl-10-deacetyl-2-debenzoyl-10-dehydro-abeo-baccat in III; 15-benzoyl-2-debenzoyl-7, 9-dideacetyl-abeo-baccatin VI; N-acetyl-
Françoise Sauriol, Orval Mamer, Lolita O Zamir   +2 more
exaly   +3 more sources