Results 51 to 60 of about 4,048 (209)

Syntheses and Structure−Activity Relationships of the Second-Generation Antitumor Taxoids:  Exceptional Activity against Drug-Resistant Cancer Cells

, 2016
A series of new 3‘-(2-methyl-1-propenyl) and 3‘-(2-methylpropyl) taxoids with modifications at C-10 was synthesized by means of the β-lactam synthon method using 10-modified 7-(triethylsilyl)-10-deacetylbaccatin III derivatives.
Ralph J. Bernacki (2402203), Scott D. Kuduk (1811911), Paula Pera (2146381), Marie-Christine Bissery (3019110), Patricia Vrignaud (849964), Evelyne Michaud (3019116), John C. Slater (3019113), Jean M. Veith (2402200), Iwao Ojima (295240), Pierre-Yves Bounaud (2688592)   +9 more
core   +1 more source

Synthesis of Taxane ABC Tricyclic Skeleton from Lycoctonine

Natural Product Communications, 2012
A new conversional synthesis of the ABC ring system of taxoids from the C 19 -diterpenoid alkaloid lycoctonine was developed in 6 steps with 2% overall yield. The distinctive features of the conversion include pinacol rearrangement, enlargement of ring B,
Xiao-Xia Liang, Pei Tang, Qiao-Hong Chen, Feng-Peng Wang   +3 more
doaj   +1 more source

Patient factors associated with discrepancies between patient-reported and clinician-documented peripheral neuropathy in women with breast cancer receiving paclitaxel: A pilot study

Breast, 2020
Purpose: Discrepancies between clinicians’ assessment of chemotherapy-induced peripheral neuropathy (CIPN) and patient-reported outcomes (PRO) have been described, though the underlying reasons are unknown. Our objective was to identify potential patient-
Teresa M. Salgado, Jin Liu, Holly L. Reed, Caroline S. Quinn, Jillian G. Syverson, Jennifer Le-Rademacher, Camden L. Lopez, Andreas S. Beutler, Charles L. Loprinzi, Kiran Vangipuram, Ellen M. Lavoie Smith, N Lynn Henry, Karen B. Farris, Daniel L. Hertz   +13 more
doaj   +1 more source

Taxezopidine-G from needles and young stems of Taxus baccata L. growing in Iran

Journal of Medicinal Plants, 2005
Background: Taxus species are important due to their content of Taxol, baccatin III, 10- deacetyl baccatin and other taxoids suitable to change to active pharmaceutical ingredients, which are used as anti-neoplastic agents.
M Pirali-Hamedani, Verdian Rizi MR, SH Rezazadeh, R Dowlatabadi, A Hadjiakhoondi, M Amini, D Yazdani   +6 more
doaj  

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, Volume 3, Issue 5, September 2025.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Synthesis and Biological Evaluation of Methoxylated Analogs of the Newer Generation Taxoids IDN5109 and IDN5390

, 2005
Starting from 10-deacetylbaccatin 111 (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized.
BOMBARDELLI E., BARBONI, L., BARBONI, Luciano, BALLINI, Roberto, E., APPENDINO G., GIARLO, Guido, FONTANA G., G. , BOMBARDELLI, G. , FONTANA, BALLINI, R., GIARLO, G., APPENDINO, Giovanni Battista   +12 more
core   +1 more source

Reactions of a-4(20)-epoxy-5-O-mesyltriacetyltaxicine I induced by BF3·Et2O/Bu4NBr [PDF]

Journal of the Serbian Chemical Society, 2006
The reaction of a-(20)-epoxy-5-O-mesyltriacetyltaxicine I (2) with BF3·Et2O/Bu4NBr can give rise to 4 different products. Each of these products can be obtained selectively, under the appropriate reaction conditions.
ZORANA FERJANCIC, RADOMIR MATOVIC, ZIVORAD CEKOVIC, RADOMIR N. SAICIC   +3 more
doaj  

Taxane Diterpenoids from Taxus baccata L. Growing in Iran

Journal of Medicinal Plants, 2009
Background: There are eight Taxus species and two hybrids in the world and Taxus baccata L. (European yew) is the single representative in Iran. Until now, a large number of taxoids possessing different skeleton systems, as well as lignans, flavonoids ...
A Hadjiakhoondi, M Pirali - Hamedani, MR Verdian-Rizi, Sh Rezazadeh   +3 more
doaj  

Adjuvant systemic treatment in luminal breast cancer — what else apart from hormone therapy?

Oncology in Clinical Practice
The luminal subtype [hormone receptor (HR) expression and absence of HER2 overexpression] occurs in more than 70% of patients with early breast cancer.
Sylwia Dębska-Szmich, Piotr Potemski
doaj   +1 more source

Cytokine Expression Profiling in Idiopathic Pulmonary Fibrosis: Insights From Integrative Proteomic Analysis

Canadian Respiratory Journal, Volume 2025, Issue 1, 2025.
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease with a poor prognosis and no effective pharmacological treatments. Cytokines are a class of small‐molecule proteins with diverse biological activities. Many cytokines—most notably transforming growth factor β—have been demonstrated to play an important role ...
Chenyou Shen, Wei Wang, Guirong Li, Dong Wei, Xusheng Yang, Cheng Jiang, Yating Sheng, Yuan Chen, Jingjing Xu, Shugao Ye, Jingyu Chen, Tan Jiang-Shan   +11 more
wiley   +1 more source